| 620705 | Homer2 | homer scaffold protein 2 | ENCODES a protein that exhibits G protein-coupled glutamate receptor binding; glutamate receptor binding; identical protein binding; INVOLVED IN cellular response to L-glutamate; regulation of glutamate secretion; response to cocaine; PARTICIPATES IN glutamate signaling pathway; ASSOCIATED WITH coca ine abuse; cocaine dependence; muscular atrophy; FOUND IN dendrite; neuronal cell body; plasma membrane; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1 | 1 | 144968207 | 145069022 | Rat | 192 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 736904 | Homer2 | homer scaffolding protein 2 | Enables actin binding activity and synaptic receptor adaptor activity. Involved in sensory perception of sound. Acts upstream of or within behavioral response to cocaine; calcium-mediated signaling; and regulation of G protein-coupled receptor signaling pathway. Located in apical part of cell; cytop lasm; and stereocilium tip. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; cranial nerve; jaw; sensory organ; and tongue. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to human HOMER2 (homer scaffold protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 81250229 | 81356673 | Mouse | 197 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1354175 | HOMER2 | homer scaffold protein 2 | This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudo genes have been identified on chromosome 14. [provided by RefSeq, Jun 2011] | 15 | 82834661 | 82986157 | Human | 187 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8838001 | Homer2 | homer scaffold protein 2 | ENCODES a protein that exhibits actin binding (ortholog); G protein-coupled glutamate receptor binding (ortholog); glutamate receptor binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); calcium-mediated signaling (ortholog); cellular response to L-glutamate (ortholog); ASSOCIA TED WITH autosomal dominant nonsyndromic deafness 68 (ortholog); cocaine abuse (ortholog); cocaine dependence (ortholog); FOUND IN apical part of cell (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955416 | 13671115 | 13828413 | Chinchilla | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11861427 | HOMER2 | homer scaffold protein 2 | ENCODES a protein that exhibits glutamate receptor binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); calcium-mediated signaling (ortholog); cellular response to L-glutamate (ortholog); ASSOCIAT ED WITH autosomal dominant nonsyndromic deafness 68 (ortholog); cocaine abuse (ortholog); cocaine dependence (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog) | 15 | 62617905 | 62762903 | Bonobo | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12666634 | Homer2 | homer scaffold protein 2 | ENCODES a protein that exhibits glutamate receptor binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); calcium-mediated signaling (ortholog); cellular response to L-glutamate (ortholog); ASSOCIAT ED WITH autosomal dominant nonsyndromic deafness 68 (ortholog); cocaine abuse (ortholog); cocaine dependence (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog); plasma membrane (ortholog) | NW_004936483 | 17500962 | 17634804 | Squirrel | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 40916469 | HOMER2 | homer scaffold protein 2 | ENCODES a protein that exhibits actin binding (inferred); G protein-coupled glutamate receptor binding (inferred); synaptic receptor adaptor activity (inferred); INVOLVED IN G protein-coupled glutamate receptor signaling pathway (inferred); negative regulation of calcineurin-NFAT signaling cascade ( inferred); negative regulation of interleukin-2 production (inferred); FOUND IN apical part of cell (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Dog | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245960 | homer2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625895127 | Homer2 | homer scaffold protein 2 | ENCODES a protein that exhibits actin binding (ortholog); G protein-coupled glutamate receptor binding (ortholog); glutamate receptor binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); calcium-mediated signaling (ortholog); cellular response to L-glutamate (ortholog); ASSOCIA TED WITH autosomal dominant nonsyndromic deafness 68 (ortholog); cocaine abuse (ortholog); cocaine dependence (ortholog); FOUND IN apical part of cell (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18927761 | Homer2 | homer scaffold protein 2 | ENCODES a protein that exhibits actin binding (ortholog); glutamate receptor binding (ortholog); identical protein binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); calcium-mediated signaling (ortholog); cellular response to L-glutamate (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 68 (ortholog); cocaine abuse (ortholog); cocaine dependence (ortholog); FOUND IN apical part of cell (ortholog); cytosol (ortholog); dendrite (ortholog) | | | | Naked Mole-Rat | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14029666 | HOMER2 | homer scaffold protein 2 | ENCODES a protein that exhibits glutamate receptor binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); calcium-mediated signaling (ortholog); cellular response to L-glutamate (ortholog); ASSOCIAT ED WITH autosomal dominant nonsyndromic deafness 68 (ortholog); cocaine abuse (ortholog); cocaine dependence (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog) | | | | Pig | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18633663 | HOMER2 | homer scaffold protein 2 | ENCODES a protein that exhibits glutamate receptor binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); calcium-mediated signaling (ortholog); cellular response to L-glutamate (ortholog); ASSOCIAT ED WITH autosomal dominant nonsyndromic deafness 68 (ortholog); cocaine abuse (ortholog); cocaine dependence (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog) | | | | Green Monkey | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243551 | homer2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256681 | homer2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1349435 | HOMER2P1 | HOMER2 pseudogene 1 | | 14 | 106458942 | 106461306 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 1352201 | HOMER2P2 | HOMER2 pseudogene 2 | | 14 | 106285995 | 106287892 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 16562423 | AC022558.2 | novel transcript, antisense to HOMER2, C15orf40 and BTBD1 | | | | | Human | | name | gene, lncrna |
| 12394805 | C3H15orf40 | chromosome 3 C15orf40 homolog | ENCODES a protein that exhibits actin binding (inferred); G protein-coupled glutamate receptor binding (inferred); synaptic receptor adaptor activity (inferred); INVOLVED IN G protein-coupled glutamate receptor signaling pathway (inferred); negative regulation of calcineurin-NFAT signaling cascade ( inferred); negative regulation of interleukin-2 production (inferred); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 68 (ortholog); Cocaine-Related Disorders (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (inferred); cytoplasm (inferred); cytosol (inferred) | 3 | 54788092 | 54793197 | Dog | 34 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |