| 71059 | Hnrnpl | heterogeneous nuclear ribonucleoprotein L | ENCODES a protein that exhibits mRNA 3'-UTR binding; mRNA CDS binding; pre-mRNA intronic binding (ortholog); INVOLVED IN cellular response to amino acid starvation; circadian rhythm; negative regulation of mRNA splicing, via spliceosome; PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH brain can cer (ortholog); Breast Neoplasms (ortholog); Disease Progression (ortholog); FOUND IN perinuclear region of cytoplasm; chromatin (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol | 1 | 93226373 | 93239084 | Rat | 162 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 737263 | HNRNPL | heterogeneous nuclear ribonucleoprotein L | Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 19 | 38836370 | 38852347 | Human | 165 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737264 | Hnrnpl | heterogeneous nuclear ribonucleoprotein L | Enables RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in pronucleus. Is active in synapse. Is expressed in several structures, including brain; early conceptus; female reproductive system; sensory organ; and tail unsegmented mesenchyme. Human ort holog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 28507971 | 28521693 | Mouse | 185 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8764228 | Hnrnpl | heterogeneous nuclear ribonucleoprotein L | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA CDS binding (ortholog); pre-mRNA intronic binding (ortholog); INVOLVED IN cellular response to amino acid starvation (ortholog); circadian rhythm (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPAT ES IN spliceosome pathway; ASSOCIATED WITH brain cancer (ortholog); Breast Neoplasms (ortholog); Disease Progression (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog) | NW_004955468 | 668177 | 683540 | Chinchilla | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11964669 | HNRNPL | heterogeneous nuclear ribonucleoprotein L | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA CDS binding (ortholog); pre-mRNA intronic binding (ortholog); INVOLVED IN cellular response to amino acid starvation (ortholog); circadian rhythm (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPAT ES IN spliceosome pathway; ASSOCIATED WITH brain cancer (ortholog); Breast Neoplasms (ortholog); Disease Progression (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog) | 19 | 35943720 | 35959795 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12385822 | HNRNPL | heterogeneous nuclear ribonucleoprotein L | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA CDS binding (ortholog); INVOLVED IN cellular response to amino acid starvation (ortholog); circadian rhythm (ortholog); negative regulation of mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIAT ED WITH brain cancer (ortholog); Breast Neoplasms (ortholog); Disease Progression (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog) | 1 | 114267195 | 114279107 | Dog | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12466510 | Hnrnpl | heterogeneous nuclear ribonucleoprotein L | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA CDS binding (ortholog); INVOLVED IN cellular response to amino acid starvation (ortholog); circadian rhythm (ortholog); negative regulation of mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIAT ED WITH brain cancer (ortholog); Breast Neoplasms (ortholog); Disease Progression (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog) | NW_004936661 | 1793791 | 1806564 | Squirrel | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14177550 | HNRNPL | heterogeneous nuclear ribonucleoprotein L | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA CDS binding (ortholog); INVOLVED IN cellular response to amino acid starvation (ortholog); circadian rhythm (ortholog); negative regulation of mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIAT ED WITH brain cancer (ortholog); Breast Neoplasms (ortholog); Disease Progression (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18479183 | HNRNPL | heterogeneous nuclear ribonucleoprotein L | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA CDS binding (ortholog); INVOLVED IN cellular response to amino acid starvation (ortholog); circadian rhythm (ortholog); negative regulation of mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIAT ED WITH brain cancer (ortholog); Breast Neoplasms (ortholog); Disease Progression (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog) | | | | Green Monkey | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904234 | Hnrnpl | heterogeneous nuclear ribonucleoprotein L | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA CDS binding (ortholog); pre-mRNA intronic binding (ortholog); INVOLVED IN cellular response to amino acid starvation (ortholog); circadian rhythm (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPAT ES IN spliceosome pathway; ASSOCIATED WITH brain cancer (ortholog); Breast Neoplasms (ortholog); Disease Progression (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251320 | hnrnpl | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625835422 | Hnrnpl | heterogeneous nuclear ribonucleoprotein L | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); mRNA CDS binding (ortholog); pre-mRNA intronic binding (ortholog); INVOLVED IN cellular response to amino acid starvation (ortholog); circadian rhythm (ortholog); negative regulation of DNA-templated transcription (ortholog); PARTICIPAT ES IN spliceosome pathway; ASSOCIATED WITH brain cancer (ortholog); Breast Neoplasms (ortholog); Disease Progression (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256739 | hnrnpl.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259596 | hnrnpl.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1588749 | Hnrnpl-ps1 | heterogeneous nuclear ribonucleoprotein L, pseudogene 1 | | 8 | 16882242 | 16882879 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1598156 | Hnrnpl-ps2 | heterogeneous nuclear ribonucleoprotein L, pseudogene 2 | | 3 | 26342667 | 26344500 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1359551 | Fblim1 | filamin binding LIM protein 1 | ENCODES a protein that exhibits filamin binding (ortholog); pre-mRNA intronic binding (ortholog); transcription cis-regulatory region binding (ortholog); INVOLVED IN cell-cell adhesion (ortholog); negative regulation of DNA-templated transcription (ortholog); regulation of alternative mRNA splicing, via spliceosome (ortholog); PARTICIPATES IN integrin mediated signaling pathway; FOUND IN cell junction (ortholog); cell periphery (ortholog); chromatin (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol | 5 | 159167004 | 159198578 | Rat | 153 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16565235 | AC008982.2 | novel transcript, sense intronic to HNRNPL | | | | | Human | | name | gene, lncrna |
| 7779641 | THRIL | TNF and HNRNPL related immunoregulatory long non-coding RNA | INTERACTS WITH 17beta-estradiol; 2-hydroxypropanoic acid; rac-lactic acid | 12 | 125025443 | 125027423 | Human | 5 | name | gene, ncrna, VALIDATED [RefSeq] |
| 1305861 | Hnrnpll | heterogeneous nuclear ribonucleoprotein L-like | ENCODES a protein that exhibits mRNA binding (ortholog); INVOLVED IN positive regulation of RNA splicing (ortholog); FOUND IN synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol | 6 | 20720013 | 20752803 | Rat | 92 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1353271 | HNRNPLL | heterogeneous nuclear ribonucleoprotein L like | HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861 ]).[supplied by OMIM, Aug 2008] | 2 | 38561969 | 38602928 | Human | 103 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1552104 | Hnrnpll | heterogeneous nuclear ribonucleoprotein L-like | Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of RNA splicing. Is active in synapse. Is expressed in central nervous system and sensory organ. Orthologous to human HNRNPLL (heterogeneous nuclear ribonucleoprotein L li ke). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 80336916 | 80369697 | Mouse | 108 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9030420 | Hnrnpll | heterogeneous nuclear ribonucleoprotein L like | ENCODES a protein that exhibits mRNA binding (ortholog); INVOLVED IN positive regulation of RNA splicing (ortholog); FOUND IN synapse (ortholog) | NW_004955441 | 6229692 | 6269051 | Chinchilla | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11788872 | HNRNPLL | heterogeneous nuclear ribonucleoprotein L like | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN mRNA processing (inferred); positive regulation of RNA splicing (inferred); regulation of RNA splicing (inferred); FOUND IN nucleus (inferred); ribonucleoprotein complex (inf erred); synapse (inferred) | 2A | 38585301 | 38629509 | Bonobo | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12194247 | HNRNPLL | heterogeneous nuclear ribonucleoprotein L like | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN mRNA processing (inferred); positive regulation of RNA splicing (inferred); FOUND IN nucleus (inferred); ribonucleoprotein complex (inferred); synapse (inferred) | 17 | 30644695 | 30684485 | Dog | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12650999 | Hnrnpll | heterogeneous nuclear ribonucleoprotein L like | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN mRNA processing (inferred); positive regulation of RNA splicing (inferred); FOUND IN nucleus (inferred); ribonucleoprotein complex (inferred); synapse (inferred) | NW_004936508 | 12653861 | 12680816 | Squirrel | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13878266 | HNRNPLL | heterogeneous nuclear ribonucleoprotein L like | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN mRNA processing (inferred); positive regulation of RNA splicing (inferred); FOUND IN nucleus (inferred); ribonucleoprotein complex (inferred); synapse (inferred); INTERACTS W ITH resveratrol | | | | Pig | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18385700 | HNRNPLL | heterogeneous nuclear ribonucleoprotein L like | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN mRNA processing (inferred); positive regulation of RNA splicing (inferred); regulation of RNA splicing (inferred); FOUND IN nucleus (inferred); synapse (inferred) | | | | Green Monkey | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930545 | Hnrnpll | heterogeneous nuclear ribonucleoprotein L like | ENCODES a protein that exhibits mRNA binding (ortholog); INVOLVED IN positive regulation of RNA splicing (ortholog); FOUND IN synapse (ortholog) | | | | Naked Mole-Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284234233 | hnrnpll | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625877495 | Hnrnpll | heterogeneous nuclear ribonucleoprotein L like | ENCODES a protein that exhibits mRNA binding (ortholog); INVOLVED IN positive regulation of RNA splicing (ortholog); FOUND IN synapse (ortholog) | | | | Black Rat | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 7246013 | HNRNPLP1 | heterogeneous nuclear ribonucleoprotein L pseudogene 1 | | 6 | 7480864 | 7482595 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7246872 | HNRNPLP2 | heterogeneous nuclear ribonucleoprotein L pseudogene 2 | INTERACTS WITH aristolochic acid A; lead diacetate | 15 | 34488659 | 34490501 | Human | 2 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 284234931 | hnrnpll.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 285148175 | hnrnpll.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 616940563 | HNRNPLL-AS1 | HNRPLL antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , Human Proteome Map | gene, ncrna |