| 2796 | Hk1 | hexokinase 1 | ENCODES a protein that exhibits ATP binding; D-glucose binding; fructokinase activity; INVOLVED IN carbohydrate phosphorylation; fructose 6-phosphate metabolic process; glucose 6-phosphate metabolic process; PARTICIPATES IN glycolysis pathway; amino sugar metabolic pathway; french type sialuria path way; ASSOCIATED WITH Chronic Intermittent Hypoxia; colorectal cancer; obesity; FOUND IN caveola; mitochondrion; protein-containing complex; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose | 20 | 30773222 | 30874814 | Rat | 400 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10710 | Hk1 | hexokinase 1 | Enables glucokinase activity and peptidoglycan binding activity. Involved in carbohydrate phosphorylation; hexose metabolic process; and positive regulation of cytokine production. Located in cytosol; membrane raft; and mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1). [provided by Alliance of Genome Resources, Apr 2025] | 10 | 62104634 | 62215699 | Mouse | 418 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737450 | HK1 | hexokinase 1 | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexo kinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016] | 10 | 69270000 | 69401882 | Human | 583 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8860373 | Hk1 | hexokinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); D-glucose binding (ortholog); fructokinase activity (ortholog); INVOLVED IN canonical glycolysis (ortholog); carbohydrate phosphorylation (ortholog); fructose 6-phosphate metabolic process (ortholog); PARTICIPATES IN amino sugar metabolic pathw ay; french type sialuria pathway; fructose and mannose metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN caveola (ortholog); cilium (ortholog); cytosol (ortholog) | NW_004955437 | 21733314 | 21824303 | Chinchilla | 114 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11882594 | HK1 | hexokinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); D-glucose binding (ortholog); glucokinase activity (ortholog); INVOLVED IN carbohydrate phosphorylation (ortholog); fructose 6-phosphate metabolic process (ortholog); glycolytic process (ortholog); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; fructose and mannose metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN caveola (ortholog); cilium (ortholog); cytosol (ortholog) | 10 | 65786940 | 65870204 | Bonobo | 130 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12222809 | HK1 | hexokinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); D-glucose binding (ortholog); glucokinase activity (ortholog); INVOLVED IN carbohydrate phosphorylation (ortholog); fructose 6-phosphate metabolic process (ortholog); glycolytic process (ortholog); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; fructose and mannose metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN caveola (ortholog); cilium (ortholog); mitochondrion (ortholog) | 4 | 20396761 | 20516889 | Dog | 127 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12637026 | Hk1 | hexokinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); D-glucose binding (ortholog); glucokinase activity (ortholog); INVOLVED IN carbohydrate phosphorylation (ortholog); fructose 6-phosphate metabolic process (ortholog); glycolytic process (ortholog); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; fructose and mannose metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN caveola (ortholog); cilium (ortholog); cytosol (ortholog) | NW_004936521 | 9067062 | 9139112 | Squirrel | 136 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257677 | hk1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18406277 | HK1 | hexokinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); D-glucose binding (ortholog); glucokinase activity (ortholog); INVOLVED IN carbohydrate phosphorylation (ortholog); fructose 6-phosphate metabolic process (ortholog); glycolytic process (ortholog); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; fructose and mannose metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN caveola (ortholog); cilium (ortholog); cytosol (ortholog) | | | | Green Monkey | 130 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914343 | Hk1 | hexokinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); D-glucose binding (ortholog); glucokinase activity (ortholog); INVOLVED IN canonical glycolysis (ortholog); carbohydrate phosphorylation (ortholog); fructose 6-phosphate metabolic process (ortholog); PARTICIPATES IN amino sugar metabolic pathwa y; french type sialuria pathway; fructose and mannose metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN caveola (ortholog); cilium (ortholog); cytosol (ortholog) | | | | Naked Mole-Rat | 122 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14222820 | HK1 | hexokinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); D-glucose binding (ortholog); glucokinase activity (ortholog); INVOLVED IN carbohydrate phosphorylation (ortholog); fructose 6-phosphate metabolic process (ortholog); glycolytic process (ortholog); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; fructose and mannose metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN caveola (ortholog); cilium (ortholog); mitochondrion (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 128 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 626095583 | Hk1 | hexokinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); D-glucose binding (ortholog); fructokinase activity (ortholog); INVOLVED IN canonical glycolysis (ortholog); carbohydrate phosphorylation (ortholog); fructose 6-phosphate metabolic process (ortholog); PARTICIPATES IN amino sugar metabolic pathw ay; french type sialuria pathway; fructose and mannose metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); anemia (ortholog); Animal Disease Models (ortholog); FOUND IN caveola (ortholog); cilium (ortholog); cytosol (ortholog) | | | | Black Rat | 114 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243888 | hk1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857593 | hk1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862193 | hk1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626183353 | hk1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864707 | hk1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861952 | hk1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1320626 | HOOK1 | hook microtubule tethering protein 1 | This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase fam ily involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] | 1 | 59814949 | 59876322 | Human | 131 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 731771 | KCNA4 | potassium voltage-gated channel subfamily A member 4 | Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscl e contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011] | 11 | 30009730 | 30017030 | Human | 130 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1349866 | KLK1 | kallikrein 1 | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members l ocated in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008] | 19 | 50819146 | 50823787 | Human | 141 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 735700 | TAC4 | tachykinin precursor 4 | This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulat e peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 17 | 49838300 | 49848069 | Human | 63 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1607503 | Hk1os | hexokinase 1, opposite strand | INTERACTS WITH triptonide | 10 | 62176013 | 62199390 | Mouse | 1 | symbol , PhenoGen | gene, ncrna, VALIDATED [RefSeq] |
| 1318610 | KLK11 | kallikrein related peptidase 11 | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members l ocated in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016] | 19 | 51022236 | 51027991 | Human | 51 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1318477 | KLK14 | kallikrein related peptidase 14 | This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] | 19 | 51077494 | 51084210 | Human | 46 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1553018 | Zdhhc20 | zinc finger, DHHC domain containing 20 | Predicted to enable protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Predicted to be involved in several processes, including peptidyl-L-cysteine S-palmitoylation; positive regulation by host of viral process; and synaptic vesicle maturation. Predicted to be located in Golgi membrane and plasma membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZDHHC20 (zinc finger DHHC-type palmitoyltransferase 20). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 58070159 | 58128288 | Mouse | 109 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1349971 | VDAC1P4 | voltage dependent anion channel 1 pseudogene 4 | VDAC4 belongs to a family of small, abundant pore-forming proteins found in the outer mitochondrial membrane. These channels are thought to form the major pathway for movement of adenine nucleotides through the outer membrane and may also function as the mitochondrial binding site for hexokinase (se e HK1; MIM 142600) and glycerol kinase (GK; MIM 300474) (Blachly-Dyson et al., 1994 [PubMed 7517385]).[supplied by OMIM, Mar 2008] | 1 | 180434796 | 180436802 | Human | | description | gene, pseudo, INFERRED [RefSeq] |
