TAC4 (tachykinin precursor 4) - Rat Genome Database

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Gene: TAC4 (tachykinin precursor 4) Homo sapiens
Analyze
Symbol: TAC4
Name: tachykinin precursor 4
RGD ID: 735700
HGNC Page HGNC:16641
Description: Enables receptor ligand activity; substance K receptor binding activity; and substance P receptor binding activity. Involved in several processes, including detection of temperature stimulus involved in sensory perception of pain; positive regulation of flagellated sperm motility; and regulation of sensory perception of pain. Located in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: EK; endokinin; hemokinin; HK-1; HK1; MGC133009; MGC133010; PPT-C; preprotachykinin C; preprotachykinin-C; tachykinin 4; tachykinin 4 (hemokinin); tachykinin-4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,838,300 - 49,848,069 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1749,838,300 - 49,848,069 (-)EnsemblGRCh38hg38GRCh38
GRCh371747,915,662 - 47,925,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,270,670 - 45,280,378 (-)NCBINCBI36Build 36hg18NCBI36
Build 341745,276,416 - 45,280,378NCBI
Celera1744,370,664 - 44,380,373 (-)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,280,680 - 43,290,389 (-)NCBIHuRef
CHM1_11747,979,629 - 47,989,333 (-)NCBICHM1_1
T2T-CHM13v2.01750,701,401 - 50,711,169 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification, localization and receptor characterization of novel mammalian substance P-like peptides. Kurtz MM, etal., Gene 2002 Aug 21;296(1-2):205-12.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10737800   PMID:11062498   PMID:11786503   PMID:12477932   PMID:12716968   PMID:15224188   PMID:16931167   PMID:17175032   PMID:17437961   PMID:19081134   PMID:20580442   PMID:20929541  
PMID:21168392   PMID:21342363   PMID:21368235   PMID:21873635   PMID:22554585   PMID:27146034   PMID:27456549   PMID:27458061   PMID:32600668   PMID:34090787   PMID:34237774  


Genomics

Comparative Map Data
TAC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,838,300 - 49,848,069 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1749,838,300 - 49,848,069 (-)EnsemblGRCh38hg38GRCh38
GRCh371747,915,662 - 47,925,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,270,670 - 45,280,378 (-)NCBINCBI36Build 36hg18NCBI36
Build 341745,276,416 - 45,280,378NCBI
Celera1744,370,664 - 44,380,373 (-)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,280,680 - 43,290,389 (-)NCBIHuRef
CHM1_11747,979,629 - 47,989,333 (-)NCBICHM1_1
T2T-CHM13v2.01750,701,401 - 50,711,169 (-)NCBIT2T-CHM13v2.0
Tac4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,152,355 - 95,160,091 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,152,355 - 95,160,091 (+)EnsemblGRCm39 Ensembl
GRCm381195,261,529 - 95,269,265 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,261,529 - 95,269,265 (+)EnsemblGRCm38mm10GRCm38
MGSCv371195,122,843 - 95,130,576 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361195,077,619 - 95,085,352 (+)NCBIMGSCv36mm8
Celera11104,876,160 - 104,883,938 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Tac4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,704,640 - 80,712,972 (+)NCBIGRCr8
mRatBN7.21080,207,824 - 80,216,156 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,207,610 - 80,216,156 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,155,936 - 85,164,269 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,653,995 - 84,662,332 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,046,770 - 80,055,108 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,081,168 - 83,089,487 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,081,168 - 83,089,481 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,891,623 - 82,899,780 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,946,235 - 83,954,475 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11083,960,604 - 83,968,845 (+)NCBI
Celera1078,980,366 - 78,988,648 (+)NCBICelera
Cytogenetic Map10q26NCBI
Tac4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545111,755,645 - 11,763,281 (+)NCBIChiLan1.0ChiLan1.0
TAC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,028,835 - 66,035,424 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11770,835,645 - 70,841,439 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01743,931,170 - 43,936,510 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11748,655,003 - 48,664,586 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,655,003 - 48,664,586 (-)Ensemblpanpan1.1panPan2
TAC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,886,197 - 25,890,083 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,882,360 - 25,889,956 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,344,049 - 25,347,995 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,680,906 - 26,684,852 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1925,448,766 - 25,452,712 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,707,949 - 25,711,895 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,837,319 - 25,841,265 (-)NCBIUU_Cfam_GSD_1.0
Tac4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,307,446 - 25,317,252 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649011,762,989 - 11,767,693 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,015,180 - 26,024,661 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,015,176 - 26,024,744 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,019,463 - 26,029,001 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,489,184 - 43,500,908 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1643,490,160 - 43,499,820 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607714,206,234 - 14,215,958 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tac4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247955,898,851 - 5,905,781 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TAC4
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q21.32-22(chr17:49137864-52147810)x1 copy number loss See cases [RCV000053432] Chr17:49137864..52147810 [GRCh38]
Chr17:47215226..50225170 [GRCh37]
Chr17:44570225..47580169 [NCBI36]
Chr17:17q21.32-22		 pathogenic
GRCh38/hg38 17q21.33(chr17:49361155-50269440)x1 copy number loss See cases [RCV000139901] Chr17:49361155..50269440 [GRCh38]
Chr17:47438517..48346801 [GRCh37]
Chr17:44793516..45701800 [NCBI36]
Chr17:17q21.33		 pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_001077506.2(TAC4):c.113C>A (p.Ala38Asp) single nucleotide variant Inborn genetic diseases [RCV003282313] Chr17:49844150 [GRCh38]
Chr17:47921512 [GRCh37]
Chr17:17q21.33		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q21.32-22(chr17:46481089-51396368)x1 copy number loss not provided [RCV000513510] Chr17:46481089..51396368 [GRCh37]
Chr17:17q21.32-22		 likely pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_001077506.2(TAC4):c.322T>G (p.Ter108Glu) single nucleotide variant not provided [RCV000971064] Chr17:49838644 [GRCh38]
Chr17:47916006 [GRCh37]
Chr17:17q21.33		 benign
NM_001077506.2(TAC4):c.200-11_200-9del deletion not provided [RCV000962525] Chr17:49841593..49841595 [GRCh38]
Chr17:47918955..47918957 [GRCh37]
Chr17:17q21.33		 benign
NM_001077506.2(TAC4):c.105+834C>T single nucleotide variant Inborn genetic diseases [RCV002974363] Chr17:49847079 [GRCh38]
Chr17:47924441 [GRCh37]
Chr17:17q21.33		 uncertain significance
NM_001077506.2(TAC4):c.191G>A (p.Arg64Gln) single nucleotide variant Inborn genetic diseases [RCV002786935] Chr17:49844072 [GRCh38]
Chr17:47921434 [GRCh37]
Chr17:17q21.33		 likely benign
NM_001077506.2(TAC4):c.105+634A>C single nucleotide variant Inborn genetic diseases [RCV002807619] Chr17:49847279 [GRCh38]
Chr17:47924641 [GRCh37]
Chr17:17q21.33		 uncertain significance
NM_001077506.2(TAC4):c.160G>A (p.Ala54Thr) single nucleotide variant Inborn genetic diseases [RCV002673650] Chr17:49844103 [GRCh38]
Chr17:47921465 [GRCh37]
Chr17:17q21.33		 uncertain significance
Single allele deletion Tricho-dento-osseous syndrome [RCV003494599] Chr17:46740736..48853218 [GRCh37]
Chr17:17q21.32-21.33		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1831
Count of miRNA genes:473
Interacting mature miRNAs:516
Transcripts:ENST00000326219, ENST00000334568, ENST00000352793, ENST00000398154, ENST00000436235, ENST00000503603, ENST00000608380, ENST00000608861
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D17S1795  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,924,994 - 47,925,165UniSTSGRCh37
Build 361745,279,993 - 45,280,164RGDNCBI36
Celera1744,379,986 - 44,380,159RGD
Cytogenetic Map17q21.33UniSTS
HuRef1743,290,002 - 43,290,175UniSTS
Marshfield Genetic Map1768.44RGD
Marshfield Genetic Map1768.44UniSTS
Genethon Genetic Map1769.4UniSTS
deCODE Assembly Map1775.53UniSTS
Stanford-G3 RH Map172118.0UniSTS
GeneMap99-GB4 RH Map17345.15UniSTS
GeneMap99-G3 RH Map172619.0UniSTS
RH70419  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,924,696 - 47,924,818UniSTSGRCh37
Build 361745,279,695 - 45,279,817RGDNCBI36
Celera1744,379,688 - 44,379,810RGD
Cytogenetic Map17q21.33UniSTS
HuRef1743,289,704 - 43,289,826UniSTS
GeneMap99-GB4 RH Map17344.75UniSTS
NCBI RH Map17638.1UniSTS
SHGC-152919  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,924,979 - 47,925,306UniSTSGRCh37
Build 361745,279,978 - 45,280,305RGDNCBI36
Celera1744,379,971 - 44,380,300RGD
Cytogenetic Map17q21.33UniSTS
HuRef1743,289,987 - 43,290,316UniSTS
TNG Radiation Hybrid Map528109.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 58 5 58 1 1 4
Low 755 1085 956 185 703 121 1266 497 600 134 725 907 67 189 770 3
Below cutoff 1485 1670 584 340 908 245 2478 1225 1835 226 598 591 100 875 1520 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001077503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001077504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001077505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001077506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_170685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC027801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF515828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF515829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF515830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF515831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF521560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY471574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BD086009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000326219   ⟹   ENSP00000325286
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1749,838,309 - 49,848,017 (-)Ensembl
RefSeq Acc Id: ENST00000334568   ⟹   ENSP00000334042
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1749,838,309 - 49,848,017 (-)Ensembl
RefSeq Acc Id: ENST00000352793   ⟹   ENSP00000340461
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1749,838,309 - 49,848,017 (-)Ensembl
RefSeq Acc Id: ENST00000398154   ⟹   ENSP00000381221
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1749,838,309 - 49,848,017 (-)Ensembl
RefSeq Acc Id: ENST00000436235   ⟹   ENSP00000399702
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1749,838,300 - 49,848,069 (-)Ensembl
RefSeq Acc Id: ENST00000503603   ⟹   ENSP00000421777
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1749,844,060 - 49,848,017 (-)Ensembl
RefSeq Acc Id: ENST00000608380
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1749,844,057 - 49,848,017 (-)Ensembl
RefSeq Acc Id: ENST00000608861
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1749,844,056 - 49,848,017 (-)Ensembl
RefSeq Acc Id: NM_001077503   ⟹   NP_001070971
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,838,300 - 49,848,069 (-)NCBI
GRCh371747,915,671 - 47,925,379 (-)ENTREZGENE
Build 361745,270,670 - 45,280,378 (-)NCBI Archive
HuRef1743,280,680 - 43,290,389 (-)ENTREZGENE
CHM1_11747,979,629 - 47,989,333 (-)NCBI
T2T-CHM13v2.01750,701,401 - 50,711,169 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001077504   ⟹   NP_001070972
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,838,300 - 49,848,069 (-)NCBI
GRCh371747,915,671 - 47,925,379 (-)ENTREZGENE
Build 361745,270,670 - 45,280,378 (-)NCBI Archive
HuRef1743,280,680 - 43,290,389 (-)ENTREZGENE
CHM1_11747,979,629 - 47,989,333 (-)NCBI
T2T-CHM13v2.01750,701,401 - 50,711,169 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001077505   ⟹   NP_001070973
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,838,300 - 49,848,069 (-)NCBI
GRCh371747,915,671 - 47,925,379 (-)ENTREZGENE
Build 361745,270,670 - 45,280,378 (-)NCBI Archive
HuRef1743,280,680 - 43,290,389 (-)ENTREZGENE
CHM1_11747,979,629 - 47,989,333 (-)NCBI
T2T-CHM13v2.01750,701,401 - 50,711,169 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001077506   ⟹   NP_001070974
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,838,300 - 49,848,069 (-)NCBI
GRCh371747,915,671 - 47,925,379 (-)ENTREZGENE
Build 361745,270,670 - 45,280,378 (-)NCBI Archive
HuRef1743,280,680 - 43,290,389 (-)ENTREZGENE
CHM1_11747,979,629 - 47,989,333 (-)NCBI
T2T-CHM13v2.01750,701,401 - 50,711,169 (-)NCBI
Sequence:
RefSeq Acc Id: NM_170685   ⟹   NP_733786
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,838,300 - 49,848,069 (-)NCBI
GRCh371747,915,671 - 47,925,379 (-)ENTREZGENE
Build 361745,270,670 - 45,280,378 (-)NCBI Archive
HuRef1743,280,680 - 43,290,389 (-)ENTREZGENE
CHM1_11747,979,629 - 47,989,333 (-)NCBI
T2T-CHM13v2.01750,701,401 - 50,711,169 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001070973   ⟸   NM_001077505
- Peptide Label: isoform delta precursor
- UniProtKB: Q86UU9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001070971   ⟸   NM_001077503
- Peptide Label: isoform beta precursor
- UniProtKB: Q86UU9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001070972   ⟸   NM_001077504
- Peptide Label: isoform gamma precursor
- UniProtKB: Q86UU9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001070974   ⟸   NM_001077506
- Peptide Label: isoform alpha-2 precursor
- UniProtKB: Q86UU9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_733786   ⟸   NM_170685
- Peptide Label: isoform alpha precursor
- UniProtKB: Q86UU8 (UniProtKB/Swiss-Prot),   Q86UU7 (UniProtKB/Swiss-Prot),   Q86UU6 (UniProtKB/Swiss-Prot),   Q6ECK8 (UniProtKB/Swiss-Prot),   Q2M2P1 (UniProtKB/Swiss-Prot),   Q8IWZ7 (UniProtKB/Swiss-Prot),   Q86UU9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000381221   ⟸   ENST00000398154
RefSeq Acc Id: ENSP00000421777   ⟸   ENST00000503603
RefSeq Acc Id: ENSP00000334042   ⟸   ENST00000334568
RefSeq Acc Id: ENSP00000325286   ⟸   ENST00000326219
RefSeq Acc Id: ENSP00000340461   ⟸   ENST00000352793
RefSeq Acc Id: ENSP00000399702   ⟸   ENST00000436235

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q86UU9-F1-model_v2 AlphaFold Q86UU9 1-113 view protein structure

Promoters
RGD ID:7235607
Promoter ID:EPDNEW_H23549
Type:initiation region
Name:TAC4_1
Description:tachykinin 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,848,175 - 49,848,235EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16641 AgrOrtholog
COSMIC TAC4 COSMIC
Ensembl Genes ENSG00000176358 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000326219 ENTREZGENE
  ENST00000326219.5 UniProtKB/Swiss-Prot
  ENST00000334568 ENTREZGENE
  ENST00000334568.8 UniProtKB/Swiss-Prot
  ENST00000352793 ENTREZGENE
  ENST00000352793.6 UniProtKB/Swiss-Prot
  ENST00000398154 ENTREZGENE
  ENST00000398154.5 UniProtKB/Swiss-Prot
  ENST00000436235 ENTREZGENE
  ENST00000436235.6 UniProtKB/Swiss-Prot
GTEx ENSG00000176358 GTEx
HGNC ID HGNC:16641 ENTREZGENE
Human Proteome Map TAC4 Human Proteome Map
InterPro Tachy_Neuro_lke_CS UniProtKB/Swiss-Prot
KEGG Report hsa:255061 UniProtKB/Swiss-Prot
NCBI Gene 255061 ENTREZGENE
OMIM 607833 OMIM
PANTHER TACHYKININ UniProtKB/Swiss-Prot
  TACHYKININ-4 UniProtKB/Swiss-Prot
PharmGKB PA134944925 PharmGKB
PROSITE TACHYKININ UniProtKB/Swiss-Prot
UniProt Q2M2P1 ENTREZGENE
  Q6ECK8 ENTREZGENE
  Q86UU6 ENTREZGENE
  Q86UU7 ENTREZGENE
  Q86UU8 ENTREZGENE
  Q86UU9 ENTREZGENE
  Q8IWZ7 ENTREZGENE
  TKN4_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q2M2P1 UniProtKB/Swiss-Prot
  Q6ECK8 UniProtKB/Swiss-Prot
  Q86UU6 UniProtKB/Swiss-Prot
  Q86UU7 UniProtKB/Swiss-Prot
  Q86UU8 UniProtKB/Swiss-Prot
  Q8IWZ7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-16 TAC4  tachykinin precursor 4  TAC4  tachykinin 4  Symbol and/or name change 5135510 APPROVED
2018-01-09 TAC4  tachykinin 4  TAC4  tachykinin 4 (hemokinin)  Symbol and/or name change 5135510 APPROVED