| 1314691 | FZD7 | frizzled class receptor 7 | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz fam ily members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008] | 2 | 202033855 | 202038441 | Human | 222 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1314692 | Fzd7 | frizzled class receptor 7 | Enables Wnt receptor activity and Wnt-protein binding activity. Involved in negative regulation of cell-substrate adhesion. Acts upstream of or within several processes, including Wnt signaling pathway; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; and substrat e adhesion-dependent cell spreading. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human FZD7 (frizzled class receptor 7). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 59521306 | 59526114 | Mouse | 246 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 2321905 | Fzd7 | frizzled class receptor 7 | ENCODES a protein that exhibits frizzled binding (ortholog); PDZ domain binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); mesenchymal to epithelial transition (ortholog); negative regulation of cardiac muscle cell di fferentiation (ortholog); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH nephroblastoma (ortholog); FOUND IN plasma membrane (ortholog); recycling endosome membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol | 9 | 68425538 | 68428357 | Rat | 230 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9039575 | Fzd7 | frizzled class receptor 7 | ENCODES a protein that exhibits frizzled binding (ortholog); PDZ domain binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); mesenchymal to epithelial transition (ortholog); negative regulation of cardiac muscle cell di fferentiation (ortholog); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH nephroblastoma (ortholog); FOUND IN plasma membrane (ortholog); recycling endosome membrane (ortholog) | NW_004955457 | 12729277 | 12733057 | Chinchilla | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11890383 | FZD7 | frizzled class receptor 7 | ENCODES a protein that exhibits frizzled binding (inferred); G protein-coupled receptor activity (inferred); PDZ domain binding (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); non-canonical Wnt signaling pathway (ortholog); skeletal muscle satellite cell maintenance involved in s keletal muscle regeneration (ortholog); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH nephroblastoma (ortholog); FOUND IN endosome membrane (inferred); membrane (inferred); plasma membrane (inferred) | 2B | 89290929 | 89294873 | Bonobo | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12345227 | FZD7 | frizzled class receptor 7 | ENCODES a protein that exhibits frizzled binding (ortholog); PDZ domain binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); mesenchymal to epithelial transition (ortholog); negative regulation of cardiac muscle cell di fferentiation (ortholog); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH nephroblastoma (ortholog); FOUND IN recycling endosome membrane (ortholog) | 37 | 11054572 | 11061173 | Dog | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12579935 | Fzd7 | frizzled class receptor 7 | ENCODES a protein that exhibits frizzled binding (inferred); G protein-coupled receptor activity (inferred); PDZ domain binding (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); non-canonical Wnt signaling pathway (ortholog); skeletal muscle satellite cell maintenance involved in s keletal muscle regeneration (ortholog); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH nephroblastoma (ortholog); FOUND IN endosome membrane (inferred); membrane (inferred); plasma membrane (inferred) | NW_004936726 | 1256684 | 1275324 | Squirrel | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14252702 | FZD7 | frizzled class receptor 7 | ENCODES a protein that exhibits frizzled binding (inferred); G protein-coupled receptor activity (inferred); PDZ domain binding (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); non-canonical Wnt signaling pathway (ortholog); skeletal muscle satellite cell maintenance involved in s keletal muscle regeneration (ortholog); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH nephroblastoma (ortholog); FOUND IN endosome membrane (inferred); membrane (inferred); plasma membrane (inferred) | | | | Pig | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625860066 | Fzd7 | frizzled class receptor 7 | ENCODES a protein that exhibits frizzled binding (ortholog); PDZ domain binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); mesenchymal to epithelial transition (ortholog); negative regulation of cardiac muscle cell di fferentiation (ortholog); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH nephroblastoma (ortholog); FOUND IN plasma membrane (ortholog); recycling endosome membrane (ortholog) | | | | Black Rat | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913265 | Fzd7 | frizzled class receptor 7 | ENCODES a protein that exhibits frizzled binding (ortholog); PDZ domain binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); mesenchymal to epithelial transition (ortholog); negative regulation of cardiac muscle cell di fferentiation (ortholog); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH nephroblastoma (ortholog); FOUND IN recycling endosome membrane (ortholog) | | | | Naked Mole-Rat | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243282 | fzd7 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 150657898 | FZD7 | frizzled class receptor 7 | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cell surface receptor signaling pathway (inferred); G protein-coupled receptor signaling pathway (inferred); signal transduction (inferred); FOUND IN endo some membrane (inferred); membrane (inferred); plasma membrane (inferred) | | | | Dog | 15 | symbol | gene, protein-coding |
| 152178043 | FZD7 | frizzled class receptor 7 | | | | | Naked Mole-Rat | | symbol | gene, protein-coding |
| 18571769 | FZD7 | frizzled class receptor 7 | ENCODES a protein that exhibits frizzled binding (inferred); G protein-coupled receptor activity (inferred); PDZ domain binding (inferred); INVOLVED IN canonical Wnt signaling pathway (ortholog); non-canonical Wnt signaling pathway (ortholog); skeletal muscle satellite cell maintenance involved in s keletal muscle regeneration (ortholog); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH nephroblastoma (ortholog); FOUND IN endosome membrane (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232112 | fzd7.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155260225 | fzd7.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1306205 | Cdk15 | cyclin-dependent kinase 15 | ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); PARTICIPATES IN syndecan signaling pathway; Wnt signaling pathway; Wnt signaling, non-canonical pathway; ASSOCIATED WITH nephroblastoma (ortholog); INTERACTS WITH vinclozolin; 2,3,7,8-tetrachlorodibenzodioxine (orth olog); aflatoxin B1 (ortholog) | 9 | 68205759 | 68299218 | Rat | 55 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |