| 1316290 | Fyb1 | FYN binding protein 1 | The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript vari ants encoding different isoforms. [provided by RefSeq, May 2013] | 15 | 6552280 | 6695089 | Mouse | 131 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1563421 | Fyb1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding; INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortholog); INTER ACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 57360084 | 57508609 | Rat | 112 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1603714 | FYB1 | FYN binding protein 1 | The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provid ed by RefSeq, Jul 2011] | 5 | 39105252 | 39274528 | Human | 145 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8820600 | Fyb1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortho log) | NW_004955426 | 23621355 | 23777086 | Chinchilla | 23 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11898598 | FYB1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortho log) | 5 | 71100184 | 71268471 | Bonobo | 23 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12109797 | FYB1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN anchoring junction (inferred); cytoplasm (inferred); plasma m embrane (inferred) | 4 | 69729481 | 69876962 | Dog | 32 | symbol , old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12576807 | Fyb1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortho log) | NW_004936518 | 3063257 | 3169469 | Squirrel | 23 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 13931172 | FYB1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN anchoring junction (inferred); cytoplasm (inferred); plasma m embrane (inferred) | | | | Pig | 32 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18471770 | FYB1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN anchoring junction (inferred); cytoplasm (inferred); plasma m embrane (inferred) | | | | Green Monkey | 32 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934805 | Fyb1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Naked Mole-Rat | 31 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1307224 | Rictor | RPTOR independent companion of MTOR, complex 2 | ENCODES a protein that exhibits ATP binding (ortholog); enzyme-substrate adaptor activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN positive regulation of endothelial cell proliferation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; r egulation of phosphorylation; PARTICIPATES IN mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH breast ductal carcinoma (ortholog); colon cancer (ortholog); colorectal adenocarcinoma (ortholog); FOUND IN endoplasmic reticulum (ortholog); lysosome (ortholog); plasma membrane (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol | 2 | 57539279 | 57631291 | Rat | 198 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 284159242 | fyb1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626030860 | Fyb1 | FYN binding protein 1 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein localization to plasma membrane (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); Thrombocytopenia 3 (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortho log) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1564074 | Fyb2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (ortholog); T cell receptor signaling pathway (ortholog); FOUND IN immunological synapse (ortholog); membrane raft (ortholog); INTERACTS WITH bisphenol A; glyphosate; lead diacetate | 5 | 124906005 | 125029867 | Rat | 67 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1604211 | FYB2 | FYN binding protein 2 | Involved in T cell receptor signaling pathway and cell adhesion mediated by integrin. Located in immunological synapse and membrane raft. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 56718789 | 56826914 | Human | 63 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1618117 | Fyb2 | FYN binding protein 2 | Predicted to be involved in cell adhesion mediated by integrin; cell surface receptor signaling pathway; and protein localization to plasma membrane. Predicted to be located in immunological synapse and membrane raft. Predicted to be active in plasma membrane. Orthologous to human FYB weight:700;'>FYB2 (FYN binding protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 104692431 | 104874061 | Mouse | 68 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8917005 | Fyb2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (ortholog); T cell receptor signaling pathway (ortholog); FOUND IN immunological synapse (ortholog); membrane raft (ortholog) | NW_004955464 | 2897292 | 2996606 | Chinchilla | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11726120 | FYB2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (inferred); integrin-mediated signaling pathway (inferred); protein localization to plasma membrane (inferred); FOUND IN immunological synapse (inferred); membrane raft (inferred); plasma membrane (inferred) | 1 | 56002100 | 56077222 | Bonobo | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12240564 | FYB2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (ortholog); T cell receptor signaling pathway (ortholog); FOUND IN immunological synapse (ortholog) | 5 | 52680685 | 52804155 | Dog | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12522202 | Fyb2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (inferred); integrin-mediated signaling pathway (inferred); protein localization to plasma membrane (inferred); FOUND IN immunological synapse (inferred); membrane raft (inferred); plasma membrane (inferred) | NW_004936522 | 4802274 | 4867954 | Squirrel | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13940404 | FYB2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (inferred); integrin-mediated signaling pathway (inferred); T cell receptor signaling pathway (inferred); FOUND IN immunological synapse (inferred); membrane raft (inferred); plasma membrane (inferred) | | | | Pig | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18765220 | FYB2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (inferred); integrin-mediated signaling pathway (inferred); protein localization to plasma membrane (inferred); FOUND IN immunological synapse (inferred); membrane raft (inferred); plasma membrane (inferred) | | | | Green Monkey | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913103 | Fyb2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (ortholog); FOUND IN immunological synapse (ortholog) | | | | Naked Mole-Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 408408904 | FYB2 | | INVOLVED IN integrin-mediated signaling pathway (inferred); FOUND IN plasma membrane (inferred) | | | | Dog | 2 | symbol | gene, protein-coding |
| 598276964 | fyb2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625879081 | Fyb2 | FYN binding protein 2 | INVOLVED IN cell adhesion mediated by integrin (ortholog); T cell receptor signaling pathway (ortholog); FOUND IN immunological synapse (ortholog); membrane raft (ortholog) | | | | Black Rat | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284158775 | fyb1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 286196765 | fyb1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468108 | fyb2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1604582 | PRAM1 | PML-RARA regulated adaptor molecule 1 | The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retin oic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008] | 19 | 8490056 | 8502640 | Human | 67 | description | gene, protein-coding, REVIEWED [RefSeq] |