| 1311315 | Frzb | frizzled-related protein | ENCODES a protein that exhibits Wnt-protein binding (ortholog); INVOLVED IN cochlea morphogenesis (ortholog); convergent extension involved in organogenesis (ortholog); inner ear morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH lung adenocarcinoma (ortholog ); lung non-small cell carcinoma (ortholog); lung squamous cell carcinoma (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 3 | 85739162 | 85772168 | Rat | 172 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1322704 | FRZB | frizzled related protein | The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010] | 2 | 182833275 | 182866637 | Human | 183 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1322705 | Frzb | frizzled-related protein | Enables Wnt-protein binding activity. Involved in negative regulation of Wnt signaling pathway; neural crest cell differentiation; and somite development. Acts upstream of or within several processes, including cochlea morphogenesis; negative regulation of canonical Wnt signaling pathway; and negati ve regulation of cell differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 80242314 | 80277740 | Mouse | 194 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8943885 | Frzb | frizzled related protein | ENCODES a protein that exhibits Wnt-protein binding (ortholog); INVOLVED IN cochlea morphogenesis (ortholog); convergent extension involved in organogenesis (ortholog); inner ear morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH lung adenocarcinoma (ortholog ); lung non-small cell carcinoma (ortholog); lung squamous cell carcinoma (ortholog) | NW_004955403 | 14598765 | 14627997 | Chinchilla | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11762706 | FRZB | frizzled related protein | ENCODES a protein that exhibits Wnt-protein binding (inferred); INVOLVED IN cochlea morphogenesis (ortholog); convergent extension involved in organogenesis (ortholog); inner ear morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH lung adenocarcinoma (ortholog ); lung non-small cell carcinoma (ortholog); lung squamous cell carcinoma (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | 2B | 70106378 | 70139333 | Bonobo | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12378494 | FRZB | frizzled related protein | ENCODES a protein that exhibits Wnt-protein binding (inferred); INVOLVED IN cochlea morphogenesis (ortholog); convergent extension involved in organogenesis (ortholog); inner ear morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH lung adenocarcinoma (ortholog ); lung non-small cell carcinoma (ortholog); lung squamous cell carcinoma (ortholog); FOUND IN extracellular region (inferred) | 36 | 25884557 | 25907436 | Dog | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12486085 | Frzb | frizzled related protein | ENCODES a protein that exhibits Wnt-protein binding (inferred); INVOLVED IN cochlea morphogenesis (ortholog); convergent extension involved in organogenesis (ortholog); inner ear morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH lung adenocarcinoma (ortholog ); lung non-small cell carcinoma (ortholog); lung squamous cell carcinoma (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | NW_004936509 | 11440414 | 11471042 | Squirrel | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18438185 | FRZB | frizzled related protein | ENCODES a protein that exhibits Wnt-protein binding (inferred); INVOLVED IN cochlea morphogenesis (ortholog); convergent extension involved in organogenesis (ortholog); inner ear morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH lung adenocarcinoma (ortholog ); lung non-small cell carcinoma (ortholog); lung squamous cell carcinoma (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914130 | Frzb | frizzled related protein | ENCODES a protein that exhibits Wnt-protein binding (inferred); INVOLVED IN cochlea morphogenesis (ortholog); convergent extension involved in organogenesis (ortholog); inner ear morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH lung adenocarcinoma (ortholog ); lung non-small cell carcinoma (ortholog); lung squamous cell carcinoma (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Naked Mole-Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238589 | frzb | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626124308 | Frzb | frizzled related protein | ENCODES a protein that exhibits Wnt-protein binding (ortholog); INVOLVED IN cochlea morphogenesis (ortholog); convergent extension involved in organogenesis (ortholog); inner ear morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH lung adenocarcinoma (ortholog ); lung non-small cell carcinoma (ortholog); lung squamous cell carcinoma (ortholog) | | | | Black Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13998579 | FRZB | frizzled related protein | ENCODES a protein that exhibits Wnt-protein binding (inferred); INVOLVED IN cochlea morphogenesis (ortholog); convergent extension involved in organogenesis (ortholog); inner ear morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH lung adenocarcinoma (ortholog ); lung non-small cell carcinoma (ortholog); lung squamous cell carcinoma (ortholog); FOUND IN extracellular region (inferred) | | | | Pig | 42 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 155239194 | frzb.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236411 | frzb.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1350997 | SFRP4 | secreted frizzled related protein 4 | Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apopto sis related gene expression. [provided by RefSeq, Jul 2008] | 7 | 37905932 | 37916817 | Human | 255 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 285454291 | frzb2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 287814289 | frzb2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288061662 | frzb2.S | | | | | | African Clawed Frog | | symbol | gene, null |