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Gene: FRZB (frizzled related protein) Homo sapiens
Symbol: FRZB
Name: frizzled related protein
Description: Predicted to have Wnt-protein binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth; and positive regulation of fat cell differentiation. Localizes to the extracellular space. Implicated in osteoarthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FRE; frezzled; FRITZ; frizzled homolog-related; frizzled-related protein 1; FRP-3; FRZB-1; FRZB-PEN; FRZB1; FZRB; hFIZ; OS1; secreted frizzled-related protein 3; sFRP-3; SFRP3; SRFP3
Mus musculus (house mouse) : Frzb (frizzled-related protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Frzb (frizzled-related protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Frzb (frizzled related protein)
Pan paniscus (bonobo/pygmy chimpanzee) : FRZB (frizzled related protein)
Canis lupus familiaris (dog) : FRZB (frizzled related protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Frzb (frizzled related protein)
Sus scrofa (pig) : FRZB (frizzled related protein)
Chlorocebus sabaeus (green monkey) : FRZB (frizzled related protein)
Heterocephalus glaber (naked mole-rat) : Frzb (frizzled related protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2182,833,275 - 182,866,637 (-)Ensembl
GRCh382182,833,275 - 182,866,637 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372183,698,002 - 183,731,498 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362183,406,982 - 183,439,743 (-)NCBINCBI36hg18NCBI36
Build 342183,524,242 - 183,557,004NCBI
Celera2177,294,242 - 177,327,734 (-)NCBI
Cytogenetic Map2q32.1NCBI
HuRef2175,555,371 - 175,588,842 (-)NCBIHuRef
CHM1_12183,703,943 - 183,737,410 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on FRZB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1322704
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.