| 2622 | Fmo1 | flavin containing dimethylaniline monoxygenase 1 | ENCODES a protein that exhibits monooxygenase activity; N,N-dimethylaniline monooxygenase activity; trimethylamine monooxygenase activity; INVOLVED IN response to lipopolysaccharide; energy homeostasis (ortholog); negative regulation of fatty acid oxidation (ortholog); PARTICIPATES IN tamoxifen phar macodynamics pathway; tamoxifen pharmacokinetics pathway; phase I biotransformation pathway via cytochrome P450; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; 1-naphthyl isothiocyanate | 13 | 77715405 | 77747666 | Rat | 308 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10593 | Fmo1 | flavin containing monooxygenase 1 | Enables hypotaurine monooxygenase activity. Involved in taurine biosynthetic process. Acts upstream of or within energy homeostasis; negative regulation of fatty acid oxidation; and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in brain; cortic al renal tubule; late tubule; and testis. Orthologous to human FMO1 (flavin containing dimethylaniline monoxygenase 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 162657130 | 162694170 | Mouse | 305 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736452 | FMO1 | flavin containing dimethylaniline monoxygenase 1 | Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Thre e forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] | 1 | 171248494 | 171285978 | Human | 297 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8951010 | Fmo1 | flavin containing dimethylaniline monoxygenase 1 | ENCODES a protein that exhibits hypotaurine monooxygenase activity (ortholog); monooxygenase activity (ortholog); N,N-dimethylaniline monooxygenase activity (ortholog); INVOLVED IN energy homeostasis (ortholog); negative regulation of fatty acid oxidation (ortholog); organic acid metabolic process ( ortholog); PARTICIPATES IN tamoxifen pharmacodynamics pathway; tamoxifen pharmacokinetics pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | NW_004955406 | 11882656 | 11915875 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11726394 | FMO1 | flavin containing dimethylaniline monoxygenase 1 | ENCODES a protein that exhibits monooxygenase activity (ortholog); N,N-dimethylaniline monooxygenase activity (ortholog); INVOLVED IN energy homeostasis (ortholog); negative regulation of fatty acid oxidation (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN tamoxifen pharmacody namics pathway; tamoxifen pharmacokinetics pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | 1 | 146742505 | 146778560 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12315211 | FMO1 | flavin containing dimethylaniline monoxygenase 1 | ENCODES a protein that exhibits hypotaurine monooxygenase activity (ortholog); monooxygenase activity (ortholog); N,N-dimethylaniline monooxygenase activity (ortholog); INVOLVED IN energy homeostasis (ortholog); negative regulation of fatty acid oxidation (ortholog); response to lipopolysaccharide ( ortholog); PARTICIPATES IN tamoxifen pharmacodynamics pathway; tamoxifen pharmacokinetics pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endoplasmic reticulum membrane | 7 | 27599230 | 27623081 | Dog | 36 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14137184 | FMO1 | flavin containing dimethylaniline monoxygenase 1 | ENCODES a protein that exhibits N,N-dimethylaniline monooxygenase activity; hypotaurine monooxygenase activity (ortholog); monooxygenase activity (ortholog); INVOLVED IN organic acid metabolic process; toxin metabolic process; energy homeostasis (ortholog); PARTICIPATES IN tamoxifen pharmacodynamics pathway; tamoxifen pharmacokinetics pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endoplasmic reticulum membrane; INTERACTS WITH chlorpromazine; cysteamine; deoxynivalenol | | | | Pig | 48 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14376572 | FMO1 | | | | | | Yeast | | symbol | gene, null |
| 18786053 | FMO1 | flavin containing dimethylaniline monoxygenase 1 | ENCODES a protein that exhibits monooxygenase activity (ortholog); N,N-dimethylaniline monooxygenase activity (ortholog); INVOLVED IN energy homeostasis (ortholog); negative regulation of fatty acid oxidation (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN tamoxifen pharmacody namics pathway; tamoxifen pharmacokinetics pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904271 | Fmo1 | flavin containing dimethylaniline monoxygenase 1 | ENCODES a protein that exhibits hypotaurine monooxygenase activity (ortholog); monooxygenase activity (ortholog); N,N-dimethylaniline monooxygenase activity (ortholog); INVOLVED IN energy homeostasis (ortholog); negative regulation of fatty acid oxidation (ortholog); organic acid metabolic process ( ortholog); PARTICIPATES IN tamoxifen pharmacodynamics pathway; tamoxifen pharmacokinetics pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235208 | fmo1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625960688 | Fmo1 | flavin containing dimethylaniline monoxygenase 1 | ENCODES a protein that exhibits hypotaurine monooxygenase activity (ortholog); monooxygenase activity (ortholog); N,N-dimethylaniline monooxygenase activity (ortholog); INVOLVED IN energy homeostasis (ortholog); negative regulation of fatty acid oxidation (ortholog); organic acid metabolic process ( ortholog); PARTICIPATES IN tamoxifen pharmacodynamics pathway; tamoxifen pharmacokinetics pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | | | | Black Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405856623 | fmo1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857144 | fmo1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859898 | fmo1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861340 | fmo1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626175676 | fmo1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626177272 | fmo1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856799 | fmo1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860779 | fmo1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861397 | fmo1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864189 | fmo1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626171592 | fmo1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626177301 | fmo1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38674514 | FMO1-AS1 | FMO1 antisense RNA 1 | | 1 | 171120372 | 171251889 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, MODEL [RefSeq] |
| 16555031 | BX284613.2 | novel transcript, antisense to FMO1 | | | | | Human | | name | gene, lncrna |
| 1559819 | Fmo13 | flavin-containing monooxygenase 13 | ENCODES a protein that exhibits flavin adenine dinucleotide binding (inferred); hypotaurine monooxygenase activity (inferred); monooxygenase activity (inferred); FOUND IN endoplasmic reticulum membrane (inferred); INTERACTS WITH copper atom; copper(0); lidocaine | 13 | 81259362 | 81271141 | Rat | 19 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1620613 | Fmo13 | flavin containing monooxygenase 13 | Predicted to enable N,N-dimethylaniline monooxygenase activity. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 166310168 | 166333704 | Mouse | 2 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 2303691 | FMO10P | flavin containing dimethylaniline monoxygenase 10, pseudogene | | 1 | 166649150 | 166699360 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 2881129 | FMO11P | flavin containing dimethylaniline monoxygenase 11, pseudogene | | 1 | 166767570 | 166792767 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1620612 | Gm4847 | predicted gene 4847 | Predicted to enable N,N-dimethylaniline monooxygenase activity. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 166456540 | 166475262 | Mouse | 15 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733627 | FMO2 | flavin containing dimethylaniline monoxygenase 2 | This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] | 1 | 171185300 | 171212686 | Human | 191 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733168 | FMO5 | flavin containing dimethylaniline monoxygenase 5 | Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Thre e forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009] | 1 | 147184305 | 147227284 | Human | 196 | description | gene, protein-coding, REVIEWED [RefSeq] |