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17 records found for search term Fgd4
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RGD IDSymbolNameDescriptionChrStartStopSpeciesAnnotationsMatchType
708357Fgd4FYVE, RhoGEF and PH domain containing 4ENCODES a protein that exhibits actin binding; actin filament binding; INVOLVED IN positive regulation of JNK cascade; positive regulation of JUN kinase activity; regulation of cell shape; ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disease type 4 (ortholog); Charcot-119790418298055190Rat163symbol , PhenoGengene, protein-coding, VALIDATED [RefSeq]
732078FGD4FYVE, RhoGEF and PH domain containing 4This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAP123239955832646050Human277symbol , COSMIC , Human Proteome Mapgene, protein-coding, REVIEWED [RefSeq]
1332050Fgd4FYVE, RhoGEF and PH domain containing 4This gene is a member of the FYVE, RhoGEF and PH domain containing (FGD) family. The encoded protein is a Cdc42-specific guanine nucleotide exchange factor (GEF) that plays an essential role in regulating the actin cytoskeleton and cell morphology. Disruption of the gene in mouse causes abnormal ner161623477416418400Mouse173symbol , PhenoGengene, protein-coding, REVIEWED [RefSeq]
8871029Fgd4FYVE, RhoGEF and PH domain containing 4ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); INVOLVED IN lamellipodium assembly (ortholog); microspike assembly (ortholog); positive regulation of JNK cascade (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth diseaNW_00495550531081313314040Chinchilla18symbolgene, protein-coding, MODEL [RefSeq]
11996836FGD4FYVE, RhoGEF and PH domain containing 4ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); INVOLVED IN lamellipodium assembly (ortholog); microspike assembly (ortholog); positive regulation of JNK cascade (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disea125357457353822971Bonobo31symbolgene, protein-coding, MODEL [RefSeq]
12192200FGD4FYVE, RhoGEF and PH domain containing 4ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); INVOLVED IN lamellipodium assembly (ortholog); microspike assembly (ortholog); positive regulation of JNK cascade (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disea271625240516464099Dog29symbolgene, protein-coding, MODEL [RefSeq]
12583131Fgd4FYVE, RhoGEF and PH domain containing 4ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); INVOLVED IN lamellipodium assembly (ortholog); microspike assembly (ortholog); positive regulation of JNK cascade (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth diseaNW_00493660736752173796329Squirrel29symbolgene, protein-coding, MODEL [RefSeq]
20866349FGD4FYVE, RhoGEF and PH domain containing 4Green Monkeysymbolgene, protein-coding
18913267Fgd4FYVE, RhoGEF and PH domain containing 4ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); INVOLVED IN lamellipodium assembly (ortholog); microspike assembly (ortholog); positive regulation of JNK cascade (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth diseaNaked Mole-Rat29symbolgene, protein-coding, MODEL [RefSeq]
13928665FGD4FYVE, RhoGEF and PH domain containing 4ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); INVOLVED IN lamellipodium assembly (ortholog); microspike assembly (ortholog); positive regulation of JNK cascade (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth diseaPig29symbolgene, protein-coding, MODEL [RefSeq]
18790216FGD4FYVE, RhoGEF and PH domain containing 4ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); INVOLVED IN lamellipodium assembly (ortholog); microspike assembly (ortholog); positive regulation of JNK cascade (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth diseaGreen Monkey28symbolgene, protein-coding, MODEL [RefSeq]
626036470Fgd4FYVE, RhoGEF and PH domain containing 4ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); INVOLVED IN lamellipodium assembly (ortholog); microspike assembly (ortholog); positive regulation of JNK cascade (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth diseaBlack Rat15symbolgene, protein-coding, MODEL [RefSeq]
155254463fgd4Tropical Clawed Frogsymbolgene, null
13936768FGD4FYVE, RhoGEF and PH domain containing 4ENCODES a protein that exhibits BH2 domain binding (ortholog); clathrin binding (ortholog); identical protein binding (ortholog); INVOLVED IN calcium ion transport (ortholog); cellular response to hypoxia (ortholog); cellular response to lipid (ortholog); PARTICIPATES IN mitochondria fission pathwayPig184symbolgene, protein-coding, MODEL [RefSeq]
155246630fgd4.LAfrican Clawed Frogsymbolgene, null
155251875fgd4.SAfrican Clawed Frogsymbolgene, null
1584931Fgd4-ps1FYVE, RhoGEF and PH domain containing 4, pseudogene 117862428878632138Ratsymbol , PhenoGengene, pseudo, MODEL [RefSeq]