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Gene: FGD4 (FYVE, RhoGEF and PH domain containing 4) Homo sapiens
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Symbol: FGD4
Name: FYVE, RhoGEF and PH domain containing 4
Description: Predicted to have guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Predicted to localize to Golgi apparatus; lamellipodium; and ruffle. Implicated in Charcot-Marie-Tooth disease type 4H.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: actin filament-binding protein frabin; actin-filament binding protein frabin; CMT4H; DKFZp313E1818; DKFZp434K1572; FGD1 family, member 4; FGD1-related F-actin-binding protein; FLJ34370; FLJ42663; FRABP; FYVE, RhoGEF and PH domain-containing protein 4; MGC57222; ZFYVE6; zinc finger FYVE domain-containing protein 6
Orthologs:
Mus musculus (house mouse) : Fgd4 (FYVE, RhoGEF and PH domain containing 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fgd4 (FYVE, RhoGEF and PH domain containing 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fgd4 (FYVE, RhoGEF and PH domain containing 4)
Pan paniscus (bonobo/pygmy chimpanzee) : FGD4 (FYVE, RhoGEF and PH domain containing 4)
Canis lupus familiaris (dog) : FGD4 (FYVE, RhoGEF and PH domain containing 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fgd4 (FYVE, RhoGEF and PH domain containing 4)
Sus scrofa (pig) : FGD4 (FYVE, RhoGEF and PH domain containing 4)
Chlorocebus sabaeus (African green monkey) : FGD4 (FYVE, RhoGEF and PH domain containing 4)
Heterocephalus glaber (naked mole-rat) : Fgd4 (FYVE, RhoGEF and PH domain containing 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1232,399,529 - 32,646,050 (+)EnsemblGRCh38hg38GRCh38
GRCh381232,399,523 - 32,646,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371232,552,518 - 32,798,984 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,546,361 - 32,684,940 (+)NCBINCBI36hg18NCBI36
Build 341232,546,360 - 32,684,940NCBI
Celera1212,475,281 - 12,619,210 (+)NCBI
Cytogenetic Map12p11.21NCBI
HuRef1232,407,492 - 32,551,291 (+)NCBIHuRef
CHM1_11232,605,553 - 32,765,483 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - curated
References - uncurated

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Comparative Map Data
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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
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Additional Information

External Database Links
 
More on FGD4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732078
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.