| 68953 | Fdps | farnesyl diphosphate synthase | ENCODES a protein that exhibits (2E,6E)-farnesyl diphosphate synthase activity; dimethylallyltranstransferase activity (ortholog); INVOLVED IN cellular response to fatty acid; farnesyl diphosphate biosynthetic process; male gonad development; PARTICIPATES IN alendronate pharmacodynamics pathway; cho lesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH alcohol use disorder; Porokeratosis 9, Multiple Types (ortholog); Postmenopausal Osteoporosis (ortholog); FOUND IN mitochondrial matrix; peroxisome; cytosol (ortholog); INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate | 2 | 176795192 | 176804816 | Rat | 390 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 69022 | FDPS | farnesyl diphosphate synthase | This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for p rotein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008] | 1 | 155308866 | 155320665 | Human | 398 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 69023 | Fdps | farnesyl diphosphate synthetase | Predicted to enable (2E,6E)-farnesyl diphosphate synthase activity and dimethylallyltranstransferase activity. Predicted to be involved in farnesyl diphosphate biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of cholesterol biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 89000895 | 89009274 | Mouse | 408 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8934033 | Fdps | farnesyl diphosphate synthase | ENCODES a protein that exhibits (2E,6E)-farnesyl diphosphate synthase activity (ortholog); dimethylallyltranstransferase activity (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cholesterol biosynthetic process via desmosterol (ortholog); cholesterol biosynthetic process via lath osterol (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Porokeratosis 9, Multiple Types (ortholog); Postmenopausal Osteoporosis (ortholog); FOUND IN cytosol (ortholog); mitochondrial matrix (ortholog); peroxisome (ortholog) | NW_004955545 | 1757090 | 1765028 | Chinchilla | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11934003 | FDPS | farnesyl diphosphate synthase | ENCODES a protein that exhibits (2E,6E)-farnesyl diphosphate synthase activity (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cholesterol biosynthetic process via desmosterol (ortholog); cholesterol biosynthetic process via lathosterol (ortholog); PARTICIPATES IN alendronate pha rmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Porokeratosis 9, Multiple Types (ortholog); Postmenopausal Osteoporosis (ortholog); FOUND IN cytosol (ortholog); mitochondrial matrix (ortholog); peroxisome (ortholog) | 1 | 130653316 | 130665196 | Bonobo | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12275227 | FDPS | farnesyl diphosphate synthase | ENCODES a protein that exhibits (2E,6E)-farnesyl diphosphate synthase activity (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); farnesyl diphosphate biosynthetic process (ortholog); male gonad development (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholestero l biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Porokeratosis 9, Multiple Types (ortholog); Postmenopausal Osteoporosis (ortholog); FOUND IN cytosol (ortholog); mitochondrial matrix (ortholog); peroxisome (ortholog) | 7 | 42241086 | 42250373 | Dog | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12580903 | Fdps | farnesyl diphosphate synthase | ENCODES a protein that exhibits (2E,6E)-farnesyl diphosphate synthase activity (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cholesterol biosynthetic process via desmosterol (ortholog); cholesterol biosynthetic process via lathosterol (ortholog); PARTICIPATES IN alendronate pha rmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Porokeratosis 9, Multiple Types (ortholog); Postmenopausal Osteoporosis (ortholog); FOUND IN cytosol (ortholog); mitochondrial matrix (ortholog); peroxisome (ortholog) | NW_004936580 | 4799354 | 4808406 | Squirrel | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14288419 | FDPS | farnesyl diphosphate synthase | ENCODES a protein that exhibits (2E,6E)-farnesyl diphosphate synthase activity (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); farnesyl diphosphate biosynthetic process (ortholog); male gonad development (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholestero l biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Porokeratosis 9, Multiple Types (ortholog); Postmenopausal Osteoporosis (ortholog); FOUND IN cytosol (ortholog); mitochondrial matrix (ortholog); peroxisome (ortholog); INTERACTS WITH cadmium atom; graphene oxide | | | | Pig | 68 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18668155 | FDPS | farnesyl diphosphate synthase | ENCODES a protein that exhibits (2E,6E)-farnesyl diphosphate synthase activity (ortholog); dimethylallyltranstransferase activity (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cholesterol biosynthetic process via desmosterol (ortholog); cholesterol biosynthetic process via lath osterol (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Porokeratosis 9, Multiple Types (ortholog); Postmenopausal Osteoporosis (ortholog); FOUND IN cytosol (ortholog); mitochondrial matrix (ortholog); peroxisome (ortholog) | | | | Green Monkey | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920212 | Fdps | farnesyl diphosphate synthase | ENCODES a protein that exhibits (2E,6E)-farnesyl diphosphate synthase activity (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cholesterol biosynthetic process via desmosterol (ortholog); cholesterol biosynthetic process via lathosterol (ortholog); PARTICIPATES IN alendronate pha rmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Porokeratosis 9, Multiple Types (ortholog); Postmenopausal Osteoporosis (ortholog); FOUND IN cytosol (ortholog); mitochondrial matrix (ortholog); peroxisome (ortholog) | | | | Naked Mole-Rat | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286812450 | fdps | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625996233 | Fdps | farnesyl diphosphate synthase | ENCODES a protein that exhibits (2E,6E)-farnesyl diphosphate synthase activity (ortholog); dimethylallyltranstransferase activity (ortholog); INVOLVED IN cellular response to fatty acid (ortholog); cholesterol biosynthetic process via desmosterol (ortholog); cholesterol biosynthetic process via lath osterol (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Porokeratosis 9, Multiple Types (ortholog); Postmenopausal Osteoporosis (ortholog); FOUND IN cytosol (ortholog); mitochondrial matrix (ortholog); peroxisome (ortholog) | | | | Black Rat | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14376415 | fdps-1 | | | | | | Roundworm | | symbol | gene, null |
| 287222144 | fdps.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 286811914 | fdps.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 41007829 | Fdps-ps1 | farnesyl diphosphate synthase, pseudogene 1 | | 16 | 5898084 | 5908427 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1584916 | Fdps-ps2 | farnesyl diphosphate synthase, pseudogene 2 | | 5 | 134406330 | 134409496 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 7746019 | Fdps-ps3 | farnesyl diphosphate synthase, pseudogene 3 | | 2 | 173089527 | 173093781 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1561594 | Fdps-ps4 | farnesyl diphosphate synthase, pseudogene 4 | INTERACTS WITH ammonium chloride; indole-3-methanol; manganese(II) chloride | 8 | 27093158 | 27094251 | Rat | 4 | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41379020 | Fdps-ps5 | farnesyl diphosphate synthase, pseudogene 5 | | X | 19941245 | 19942346 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1560208 | Fdpsl1 | farnesyl diphosphate synthase like 1 | INTERACTS WITH bisphenol A; manganese(II) chloride; N-methyl-4-phenylpyridinium | 2 | 181743715 | 181744216 | Rat | 4 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1606652 | FDPSP1 | farnesyl diphosphate synthase pseudogene 1 | | 1 | 187563027 | 187564175 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1602263 | FDPSP2 | farnesyl diphosphate synthase pseudogene 2 | INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; benzo[a]pyrene; bisphenol F | 7 | 76470020 | 76475000 | Human | 6 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, PROVISIONAL [RefSeq] |
| 1350506 | FDPSP3 | farnesyl diphosphate synthase pseudogene 3 | | 14 | 54884807 | 54886244 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1347692 | FDPSP4 | farnesyl diphosphate synthase pseudogene 4 | | 15 | 42939253 | 42940404 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1345163 | FDPSP5 | farnesyl diphosphate synthase pseudogene 5 | | X | 44475971 | 44477480 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1353374 | FDPSP6 | farnesyl diphosphate synthase pseudogene 6 | | 21 | 20388287 | 20388845 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 2303432 | FDPSP7 | farnesyl diphosphate synthase pseudogene 7 | | 7 | 76968136 | 76969310 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 4144937 | FDPSP8 | farnesyl diphosphate synthase pseudogene 8 | INTERACTS WITH aristolochic acid A | 1 | 211660133 | 211661299 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4144923 | FDPSP9 | farnesyl diphosphate synthase pseudogene 9 | | 15 | 79944444 | 79945632 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4145239 | FDPSP10 | farnesyl diphosphate synthase pseudogene 10 | | 15 | 43140094 | 43141267 | Human | | symbol , GTEx , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |