| 1308182 | Elmo1 | engulfment and cell motility 1 | ENCODES a protein that exhibits guanyl nucleotide exchange factor activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); SH3 domain binding (ortholog); INVOLVED IN regulation of postsynapse assembly; actin cytoskeleton organization (ortholog); actin filament-based proc ess (ortholog); PARTICIPATES IN chemokine mediated signaling pathway; ASSOCIATED WITH Diabetic Nephropathies (ortholog); esophagus adenocarcinoma (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN glutamatergic synapse; postsynapse; cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol | 17 | 48982188 | 49518525 | Rat | 145 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1317811 | ELMO1 | engulfment and cell motility 1 | This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucl eotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] | 7 | 36852906 | 37449326 | Human | 136 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1317812 | Elmo1 | engulfment and cell motility 1 | Predicted to enable SH3 domain binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Acts upstream of or within actin filament-based process and phagocytosis. Part of guanyl-nucleotide exchange factor complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; nervous system; retina; and vibrissa. Orthologous to human ELMO1 (engulfment and cell motility 1). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 20274677 | 20792523 | Mouse | 181 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8894233 | Elmo1 | engulfment and cell motility 1 | ENCODES a protein that exhibits guanyl nucleotide exchange factor activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); SH3 domain binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament-based process (ortholog); cell motility (ortho log); ASSOCIATED WITH Diabetic Nephropathies (ortholog); esophagus adenocarcinoma (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); guanyl-nucleotide exchange factor complex (ortholog) | NW_004955460 | 6044827 | 6580770 | Chinchilla | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11832916 | ELMO1 | engulfment and cell motility 1 | ENCODES a protein that exhibits guanyl nucleotide exchange factor activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); SH3 domain binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament-based process (ortholog); cell motility (ortho log); ASSOCIATED WITH Diabetic Nephropathies (ortholog); esophagus adenocarcinoma (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); guanyl-nucleotide exchange factor complex (ortholog) | 7 | 37493854 | 38085555 | Bonobo | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12129071 | ELMO1 | engulfment and cell motility 1 | ENCODES a protein that exhibits guanyl nucleotide exchange factor activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); SH3 domain binding (inferred); INVOLVED IN actin filament-based process (ortholog); phagocytosis (ortholog); regulation of postsynapse assembly (ort holog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); esophagus adenocarcinoma (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog) | 14 | 48163218 | 48610626 | Dog | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12527546 | Elmo1 | engulfment and cell motility 1 | ENCODES a protein that exhibits guanyl nucleotide exchange factor activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); SH3 domain binding (inferred); INVOLVED IN actin filament-based process (ortholog); phagocytosis (ortholog); regulation of postsynapse assembly (ort holog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); esophagus adenocarcinoma (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN cytoplasm (inferred); glutamatergic synapse (inferred); guanyl-nucleotide exchange factor complex (inferred) | NW_004936478 | 12308255 | 12754957 | Squirrel | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903389 | Elmo1 | engulfment and cell motility 1 | ENCODES a protein that exhibits guanyl nucleotide exchange factor activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament-based process (ortholog); phagocytosis (ortholog); ASSOCIATED WITH Diabetic N ephropathies (ortholog); esophagus adenocarcinoma (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog) | | | | Naked Mole-Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288061698 | elmo1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14269934 | ELMO1 | engulfment and cell motility 1 | ENCODES a protein that exhibits acyloxyacyl hydrolase activity (inferred); guanyl nucleotide exchange factor activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN actin filament-based process (ortholog); phagocytosis (ortholog); regulation of postsynapse a ssembly (ortholog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); esophagus adenocarcinoma (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog) | | | | Pig | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625879318 | Elmo1 | engulfment and cell motility 1 | ENCODES a protein that exhibits guanyl nucleotide exchange factor activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); SH3 domain binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament-based process (ortholog); cell motility (ortho log); ASSOCIATED WITH Diabetic Nephropathies (ortholog); esophagus adenocarcinoma (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); guanyl-nucleotide exchange factor complex (ortholog) | | | | Black Rat | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18536024 | ELMO1 | engulfment and cell motility 1 | ENCODES a protein that exhibits guanyl nucleotide exchange factor activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); SH3 domain binding (inferred); INVOLVED IN actin filament-based process (ortholog); phagocytosis (ortholog); regulation of postsynapse assembly (ort holog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); esophagus adenocarcinoma (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN cytoplasm (inferred); glutamatergic synapse (inferred); guanyl-nucleotide exchange factor complex (inferred) | | | | Green Monkey | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285118734 | elmo1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 5686924 | ELMO1-AS1 | ELMO1 antisense RNA 1 | INTERACTS WITH acetochlor; herbicide | 7 | 36997796 | 37013630 | Human | 2 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |