| 621357 | E2f5 | E2F transcription factor 5 | ENCODES a protein that exhibits sequence-specific DNA binding; DNA-binding transcription activator activity (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); regulation of DNA-templated transcription (o rtholog); PARTICIPATES IN cell cycle pathway, mitotic; G1 phase pathway; transforming growth factor-beta superfamily mediated signaling pathway; ASSOCIATED WITH Disease Progression (ortholog); hydrocephalus (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN sarcoplasm; cytoplasm (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol | 2 | 88718567 | 88734143 | Rat | 143 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731057 | E2F5 | E2F transcription factor 5 | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain sev eral evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008] | 8 | 85177154 | 85214518 | Human | 147 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 731058 | E2f5 | E2F transcription factor 5 | Enables DNA-binding transcription factor activity. Acts upstream of or within animal organ morphogenesis and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human E2F5 (E2F transcription factor 5). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 14638370 | 14671369 | Mouse | 170 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8920227 | E2f5 | E2F transcription factor 5 | ENCODES a protein that exhibits DNA-binding transcription activator activity (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); regulation of DNA-tem plated transcription (ortholog); ASSOCIATED WITH Disease Progression (ortholog); hydrocephalus (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955417 | 3131282 | 3155872 | Chinchilla | 23 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11808501 | E2F5 | E2F transcription factor 5 | ENCODES a protein that exhibits sequence-specific DNA binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Disease Progression (ortholog); hydrocephalus (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN sarcoplasm (ortholog) | 8 | 81703423 | 81739827 | Bonobo | 38 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12329260 | E2F5 | E2F transcription factor 5 | ENCODES a protein that exhibits sequence-specific DNA binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Disease Progression (ortholog); hydrocephalus (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN sarcoplasm (ortholog) | 29 | 31745211 | 31754940 | Dog | 37 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12719096 | E2f5 | E2F transcription factor 5 | ENCODES a protein that exhibits sequence-specific DNA binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Disease Progression (ortholog); hydrocephalus (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN sarcoplasm (ortholog) | NW_004936544 | 124243 | 153325 | Squirrel | 37 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18553051 | E2F5 | E2F transcription factor 5 | ENCODES a protein that exhibits sequence-specific DNA binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Disease Progression (ortholog); hydrocephalus (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN sarcoplasm (ortholog) | | | | Green Monkey | 38 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18934492 | E2f5 | E2F transcription factor 5 | ENCODES a protein that exhibits DNA-binding transcription activator activity (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); regulation of DNA-tem plated transcription (ortholog); ASSOCIATED WITH Disease Progression (ortholog); hydrocephalus (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); sarcoplasm (ortholog) | | | | Naked Mole-Rat | 34 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155251465 | e2f5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626074437 | E2f5 | E2F transcription factor 5 | ENCODES a protein that exhibits DNA-binding transcription activator activity (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); regulation of DNA-tem plated transcription (ortholog); ASSOCIATED WITH Disease Progression (ortholog); hydrocephalus (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 23 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14110004 | E2F5 | E2F transcription factor 5 | ENCODES a protein that exhibits sequence-specific DNA binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Disease Progression (ortholog); hydrocephalus (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN sarcoplasm (ortholog) | | | | Pig | 37 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155246686 | e2f5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241741 | e2f5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16562774 | E2F5-DT | E2F5 divergent transcript | | 8 | 85172077 | 85177041 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 41035119 | E2f5-ps1 | E2F transcription factor 5, pseudogene 1 | | 1 | 74990532 | 74992189 | Rat | | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16560136 | AC011773.1 | novel transcript, antisense to E2F5 | | | | | Human | | name | gene, lncrna |
| 18908953 | LOC101711376 | transcription factor E2F5 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18900602 | LOC101713012 | transcription factor E2F5 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18915538 | LOC101715131 | transcription factor E2F5 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 9437161 | LOC103690334 | transcription factor E2F5 pseudogene | | | | | Rat | | name | gene, pseudo |
| 18915070 | LOC106010443 | transcription factor E2F5 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18925588 | LOC106010815 | transcription factor E2F5 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |