| 735026 | Dusp7 | dual specificity phosphatase 7 | ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN negative regulation of MAP kinase activity (ortholog); peptidyl-tyrosine dephosphorylation (ortholog); PARTICIPATES IN mitogen activated protein kinase signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 2-amino-2-deoxy-D-glucopyranose; 3-chloropropane-1,2-diol; 4,4'-sulfonyldiphenol | 8 | 115888091 | 115895126 | Rat | 118 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1350752 | DUSP7 | dual specificity phosphatase 7 | Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009] | 3 | 52048919 | 52056571 | Human | 128 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1550083 | Dusp7 | dual specificity phosphatase 7 | Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade; peptidyl-tyrosine dephosphorylation; and signal transduction. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; ear; genitourinary system; integumental system; and nervous system. Orthologous to human DUSP7 (dual specificity phosphatase 7). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 106245831 | 106252923 | Mouse | 131 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8744555 | Dusp7 | dual specificity phosphatase 7 | ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN negative regulation of MAP kinase activity (ortholog); peptidyl-tyrosine dephosphorylation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytosol (ortholog) | NW_004955532 | 3685137 | 3691933 | Chinchilla | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11678625 | DUSP7 | dual specificity phosphatase 7 | ENCODES a protein that exhibits hydrolase activity (inferred); MAP kinase tyrosine phosphatase activity (inferred); MAP kinase tyrosine/serine/threonine phosphatase activity (inferred); INVOLVED IN negative regulation of MAP kinase activity (ortholog); peptidyl-tyrosine dephosphorylation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 3 | 51990115 | 51997627 | Bonobo | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12228645 | DUSP7 | dual specificity phosphatase 7 | ENCODES a protein that exhibits hydrolase activity (inferred); MAP kinase tyrosine/serine/threonine phosphatase activity (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN negative regulation of MAP kinase activity (ortholog); peptidyl-tyrosine dephosphorylation (ortholog); ASSO CIATED WITH COVID-19 (ortholog); FOUND IN cytosol (ortholog) | 20 | 37676077 | 37682003 | Dog | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18758286 | DUSP7 | dual specificity phosphatase 7 | ENCODES a protein that exhibits hydrolase activity (inferred); MAP kinase tyrosine phosphatase activity (inferred); MAP kinase tyrosine/serine/threonine phosphatase activity (inferred); INVOLVED IN negative regulation of MAP kinase activity (ortholog); peptidyl-tyrosine dephosphorylation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625868853 | Dusp7 | dual specificity phosphatase 7 | ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN negative regulation of MAP kinase activity (ortholog); peptidyl-tyrosine dephosphorylation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytosol (ortholog) | | | | Black Rat | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14075516 | DUSP7 | dual specificity phosphatase 7 | ENCODES a protein that exhibits hydrolase activity (inferred); MAP kinase tyrosine/serine/threonine phosphatase activity (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN negative regulation of MAP kinase activity (ortholog); peptidyl-tyrosine dephosphorylation (ortholog); ASSO CIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Pig | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285659040 | dusp7 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18905129 | Dusp7 | dual specificity phosphatase 7 | ENCODES a protein that exhibits hydrolase activity (inferred); MAP kinase tyrosine phosphatase activity (inferred); MAP kinase tyrosine/serine/threonine phosphatase activity (inferred); INVOLVED IN negative regulation of MAP kinase activity (ortholog); peptidyl-tyrosine dephosphorylation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284573035 | dusp7.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 286787421 | dusp7.S | | | | | | African Clawed Frog | | symbol | gene, null |
