| 620854 | Dusp5 | dual specificity phosphatase 5 | ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity; phosphatase activity (ortholog); protein tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN negative regulation of DNA-templated transcription; negative regulation of vasoconstriction; posi tive regulation of cerebral blood circulation; PARTICIPATES IN mitogen activated protein kinase signaling pathway; ASSOCIATED WITH decreased vasoconstriction; ASSOCIATED WITH Brain Injuries; Cardiac Fibrosis; Fetal Growth Retardation; FOUND IN nucleus (inferred); INTERACTS WITH 1,2,4-trimethylbenzene; 1,3-dinitrobenzene; 17alpha-ethynylestradiol | 1 | 262543774 | 262557201 | Rat | 305 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1345576 | DUSP5 | dual specificity phosphatase 5 | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated prote in (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008] | 10 | 110497907 | 110511533 | Human | 306 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1622924 | Dusp5 | dual specificity phosphatase 5 | Predicted to enable MAP kinase tyrosine/serine/threonine phosphatase activity. Predicted to be involved in several processes, including endoderm formation; protein dephosphorylation; and regulation of blood circulation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structu res, including alimentary system; cerebellum; lung; retina layer; and telencephalon mantle layer. Orthologous to human DUSP5 (dual specificity phosphatase 5). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 53517576 | 53530240 | Mouse | 318 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8928062 | Dusp5 | dual specificity phosphatase 5 | ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity (ortholog); phosphatase activity (ortholog); protein tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN dephosphorylation (ortholog); negative regulation of DNA-templated transcription (orth olog); negative regulation of vasoconstriction (ortholog); ASSOCIATED WITH atherosclerosis (ortholog); Brain Injuries (ortholog); Cardiac Fibrosis (ortholog) | NW_004955485 | 914250 | 927640 | Chinchilla | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11743052 | DUSP5 | dual specificity phosphatase 5 | ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity (ortholog); phosphatase activity (ortholog); protein tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN dephosphorylation (ortholog); negative regulation of DNA-templated transcription (orth olog); negative regulation of vasoconstriction (ortholog); ASSOCIATED WITH atherosclerosis (ortholog); Brain Injuries (ortholog); Cardiac Fibrosis (ortholog) | 10 | 107091147 | 107105971 | Bonobo | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12166745 | DUSP5 | dual specificity phosphatase 5 | ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN dephosphorylation (ortholog); negative regulation of DNA-templated transcription (ortholog); negative regulation of vasoconstriction (ortholog); ASSOCIATED WITH atherosclerosis (ortholog ); Brain Injuries (ortholog); Cardiac Fibrosis (ortholog); FOUND IN nucleus (inferred) | 28 | 21829891 | 21844590 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12586743 | Dusp5 | dual specificity phosphatase 5 | ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN dephosphorylation (ortholog); negative regulation of DNA-templated transcription (ortholog); negative regulation of vasoconstriction (ortholog); ASSOCIATED WITH atherosclerosis (ortholog ); Brain Injuries (ortholog); Cardiac Fibrosis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | NW_004936486 | 1351077 | 1361002 | Squirrel | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14017793 | DUSP5 | dual specificity phosphatase 5 | ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN dephosphorylation (ortholog); negative regulation of DNA-templated transcription (ortholog); negative regulation of vasoconstriction (ortholog); ASSOCIATED WITH atherosclerosis (ortholog ); Brain Injuries (ortholog); Cardiac Fibrosis (ortholog); FOUND IN nucleus (inferred) | | | | Pig | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931166 | Dusp5 | dual specificity phosphatase 5 | ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity (ortholog); phosphatase activity (ortholog); INVOLVED IN dephosphorylation (ortholog); negative regulation of DNA-templated transcription (ortholog); negative regulation of vasoconstriction (ortholog); ASSOCIAT ED WITH atherosclerosis (ortholog); Brain Injuries (ortholog); Cardiac Fibrosis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625981839 | Dusp5 | dual specificity phosphatase 5 | ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity (ortholog); phosphatase activity (ortholog); protein tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN dephosphorylation (ortholog); negative regulation of DNA-templated transcription (orth olog); negative regulation of vasoconstriction (ortholog); ASSOCIATED WITH atherosclerosis (ortholog); Brain Injuries (ortholog); Cardiac Fibrosis (ortholog) | | | | Black Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252628 | dusp5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18726286 | DUSP5 | dual specificity phosphatase 5 | ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN dephosphorylation (ortholog); negative regulation of DNA-templated transcription (ortholog); negative regulation of vasoconstriction (ortholog); ASSOCIATED WITH atherosclerosis (ortholog ); Brain Injuries (ortholog); Cardiac Fibrosis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866108 | DUSP5 | dual specificity phosphatase 5 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 155236662 | dusp5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247281 | dusp5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 36049828 | DUSP5-DT | DUSP5 divergent transcript | | 10 | 110474342 | 110496482 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16566720 | DUSP5-DT | DUSP5 divergent transcript | | | | | Human | | symbol , COSMIC , name , Human Proteome Map | gene, lncrna |
| 13451539 | Dusp5em1Mcwi | dual specificity phosphatase 5; ZFN induced mutant1, Mcwi | ASSOCIATED WITH decreased vasoconstriction | | | | Rat | 1 | symbol , description , old_gene_symbol | gene, allele |
| 1602255 | DUSP5P1 | dual specificity phosphatase 5 pseudogene 1 | INTERACTS WITH aflatoxin B1; all-trans-retinoic acid; crocidolite asbestos | 1 | 228644910 | 228652425 | Human | 15 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |
| 7083547 | DUSP5P2 | dual specificity phosphatase 5 pseudogene 2 | | 3 | 9601690 | 9602908 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1347334 | RHOU | ras homolog family member U | This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferatio n. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011] | 1 | 228644647 | 228746669 | Human | 164 | description | gene, protein-coding, REVIEWED [RefSeq] |
