DUSP5 (dual specificity phosphatase 5) - Rat Genome Database

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Gene: DUSP5 (dual specificity phosphatase 5) Canis lupus familiaris
Analyze
Symbol: DUSP5
Name: dual specificity phosphatase 5
RGD ID: 12166745
Description: ENCODES a protein that exhibits MAP kinase tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of vasoconstriction (ortholog); positive regulation of cerebral blood circulation (ortholog); ASSOCIATED WITH atherosclerosis (ortholog); Brain Injuries (ortholog); Cardiac Fibrosis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity protein phosphatase 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12821,829,891 - 21,844,590 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2821,829,921 - 21,841,454 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2821,983,301 - 21,995,944 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02822,356,548 - 22,369,215 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2822,356,266 - 22,369,200 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12821,916,200 - 21,928,876 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02821,920,279 - 21,932,914 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02822,056,666 - 22,069,360 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DUSP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12821,829,891 - 21,844,590 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2821,829,921 - 21,841,454 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2821,983,301 - 21,995,944 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02822,356,548 - 22,369,215 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2822,356,266 - 22,369,200 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12821,916,200 - 21,928,876 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02821,920,279 - 21,932,914 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02822,056,666 - 22,069,360 (+)NCBIUU_Cfam_GSD_1.0
DUSP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810110,497,907 - 110,511,533 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10110,497,907 - 110,511,533 (+)EnsemblGRCh38hg38GRCh38
GRCh3710112,257,665 - 112,271,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610112,247,615 - 112,261,292 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410112,247,665 - 112,261,285NCBI
Celera10105,989,248 - 106,002,922 (+)NCBICelera
Cytogenetic Map10q25.2NCBI
HuRef10105,887,410 - 105,900,899 (+)NCBIHuRef
CHM1_110112,539,502 - 112,553,176 (+)NCBICHM1_1
T2T-CHM13v2.010111,381,715 - 111,395,339 (+)NCBIT2T-CHM13v2.0
Dusp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391953,517,576 - 53,530,240 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1953,517,540 - 53,530,862 (+)EnsemblGRCm39 Ensembl
GRCm381953,529,145 - 53,541,809 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1953,529,109 - 53,542,431 (+)EnsemblGRCm38mm10GRCm38
MGSCv371953,603,808 - 53,615,812 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361953,582,342 - 53,595,731 (+)NCBIMGSCv36mm8
Celera1955,721,417 - 55,733,621 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1947.98NCBI
Dusp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81262,543,774 - 262,557,201 (+)NCBIGRCr8
mRatBN7.21252,538,408 - 252,555,320 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1252,538,449 - 252,551,818 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1260,727,398 - 260,740,843 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01267,433,474 - 267,446,919 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01260,088,694 - 260,102,130 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01274,245,184 - 274,258,595 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,245,184 - 274,258,595 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01281,658,075 - 281,671,486 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41259,754,234 - 259,767,645 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11259,965,278 - 259,978,690 (+)NCBI
Celera1248,260,550 - 248,274,143 (+)NCBICelera
Cytogenetic Map1q55NCBI
Dusp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955485915,353 - 927,460 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955485914,250 - 927,640 (-)NCBIChiLan1.0ChiLan1.0
DUSP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28122,378,353 - 122,434,622 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110122,383,709 - 122,398,623 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010107,091,147 - 107,105,971 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110110,545,021 - 110,556,445 (+)NCBIpanpan1.1PanPan1.1panPan2
Dusp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721324,200,271 - 24,210,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364861,347,885 - 1,359,903 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364861,351,077 - 1,361,002 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14120,906,343 - 120,919,384 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114120,906,340 - 120,919,398 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214131,791,167 - 131,803,458 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19103,435,015 - 103,449,100 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9103,435,343 - 103,449,171 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604864,637,733 - 64,651,729 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473735,784,852 - 35,798,382 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473735,785,133 - 35,798,201 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DUSP5
148 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 4 22 6 6 6 6 4 12 8 10 6
Low 1 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000047477   ⟹   ENSCAFP00000040487
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2821,829,921 - 21,841,454 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845050292   ⟹   ENSCAFP00845039426
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2822,356,266 - 22,369,200 (+)Ensembl
RefSeq Acc Id: XM_038440540   ⟹   XP_038296468
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02822,356,548 - 22,369,215 (+)NCBI
RefSeq Acc Id: XM_038515167   ⟹   XP_038371095
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12821,916,200 - 21,928,876 (+)NCBI
RefSeq Acc Id: XM_038578769   ⟹   XP_038434697
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02822,056,666 - 22,069,360 (+)NCBI
RefSeq Acc Id: XM_038642950   ⟹   XP_038498878
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02821,920,279 - 21,932,914 (+)NCBI
RefSeq Acc Id: XM_544014   ⟹   XP_544014
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12821,829,891 - 21,844,590 (+)NCBI
Dog10K_Boxer_Tasha2821,983,301 - 21,995,944 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_544014   ⟸   XM_544014
- UniProtKB: A0A8C0P5F9 (UniProtKB/TrEMBL),   A0A8C0KFM5 (UniProtKB/TrEMBL),   A0A8I3Q097 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000040487   ⟸   ENSCAFT00000047477
RefSeq Acc Id: XP_038371095   ⟸   XM_038515167
RefSeq Acc Id: XP_038498878   ⟸   XM_038642950
RefSeq Acc Id: XP_038296468   ⟸   XM_038440540
- UniProtKB: A0A8C0P5F9 (UniProtKB/TrEMBL),   A0A8C0KFM5 (UniProtKB/TrEMBL),   A0A8I3Q097 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038434697   ⟸   XM_038578769
- UniProtKB: A0A8C0KFM5 (UniProtKB/TrEMBL),   A0A8C0P5F9 (UniProtKB/TrEMBL),   A0A8I3Q097 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845039426   ⟸   ENSCAFT00845050292
Protein Domains
Rhodanese   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Promoters
RGD ID:13688332
Promoter ID:EPDNEW_C6400
Type:initiation region
Name:DUSP5_1
Description:dual specificity phosphatase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12821,829,677 - 21,829,737EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030565 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030019909 UniProtKB/TrEMBL
  ENSCAFG00040019284 UniProtKB/TrEMBL
  ENSCAFG00845028505 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000047477.3 UniProtKB/TrEMBL
  ENSCAFT00030036549.1 UniProtKB/TrEMBL
  ENSCAFT00040035652.1 UniProtKB/TrEMBL
  ENSCAFT00845050292 ENTREZGENE
  ENSCAFT00845050292.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/TrEMBL
  MKP UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/TrEMBL
KEGG Report cfa:486884 UniProtKB/TrEMBL
NCBI Gene DUSP5 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 5 UniProtKB/TrEMBL
Pfam DSPc UniProtKB/TrEMBL
  Rhodanese UniProtKB/TrEMBL
PIRSF MAPK_Ptase UniProtKB/TrEMBL
PRINTS MAPKPHPHTASE UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
SMART DSPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
  RHOD UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
  SSF52821 UniProtKB/TrEMBL
UniProt A0A8C0KFM5 ENTREZGENE
  A0A8C0P5F9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q097 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40134 ENTREZGENE