| 1310343 | Dclre1b | DNA cross-link repair 1B | ENCODES a protein that exhibits 5'-3' exonuclease activity (ortholog); beta-lactamase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN interstrand cross-link repair (ortholog); protection from non-homologous end joining at telomere (ortholog); telomere capping (ortholog ); ASSOCIATED WITH Autosomal Recessive Dyskeratosis Congenita 8 (ortholog); Fanconi anemia complementation group C (ortholog); Hoyeraal-Hreidarsson Syndrome (ortholog); FOUND IN centrosome (ortholog); chromosome, telomeric region (ortholog); nuclear body (ortholog); INTERACTS WITH 17beta-estradiol; bisphenol A; cadmium atom | 2 | 193998350 | 194006873 | Rat | 137 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1321192 | DCLRE1B | DNA cross-link repair 1B | DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [ PubMed 10848582]).[supplied by OMIM, Mar 2008] | 1 | 113904619 | 113914086 | Human | 140 | symbol , old_gene_name , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1321193 | Dclre1b | DNA cross-link repair 1B | Enables 5'-3' exonuclease activity. Involved in protection from non-homologous end joining at telomere; telomeric 3' overhang formation; and telomeric loop formation. Located in chromosome, telomeric region. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene imp licated in dyskeratosis congenita. Orthologous to human DCLRE1B (DNA cross-link repair 1B). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 103707921 | 103716703 | Mouse | 126 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8943139 | Dclre1b | DNA cross-link repair 1B | ENCODES a protein that exhibits 5'-3' exonuclease activity (ortholog); beta-lactamase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN interstrand cross-link repair (ortholog); protection from non-homologous end joining at telomere (ortholog); telomere capping (ortholog ); ASSOCIATED WITH Autosomal Recessive Dyskeratosis Congenita 8 (ortholog); Fanconi anemia complementation group C (ortholog); Hoyeraal-Hreidarsson Syndrome (ortholog); FOUND IN centrosome (ortholog); chromosome, telomeric region (ortholog); nuclear body (ortholog) | NW_004955435 | 17173975 | 17179986 | Chinchilla | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12015257 | DCLRE1B | DNA cross-link repair 1B | ENCODES a protein that exhibits 5'-3' DNA exonuclease activity (inferred); 5'-3' exonuclease activity (inferred); beta-lactamase activity (inferred); INVOLVED IN DNA damage response (inferred); DNA repair (inferred); double-strand break repair via nonhomologous end joining (inferred); ASSOCIATED WIT H Autosomal Recessive Dyskeratosis Congenita 8 (ortholog); Fanconi anemia complementation group C (ortholog); Hoyeraal-Hreidarsson Syndrome (ortholog); FOUND IN centrosome (inferred); chromosome, telomeric region (inferred); nuclear body (inferred) | 1 | 88643664 | 88651962 | Bonobo | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12281193 | DCLRE1B | DNA cross-link repair 1B | ENCODES a protein that exhibits 5'-3' exonuclease activity (inferred); beta-lactamase activity (inferred); exonuclease activity (inferred); INVOLVED IN DNA damage response (inferred); DNA repair (inferred); interstrand cross-link repair (inferred); ASSOCIATED WITH Autosomal Recessive Dyskeratosis Co ngenita 8 (ortholog); Fanconi anemia complementation group C (ortholog); Hoyeraal-Hreidarsson Syndrome (ortholog); FOUND IN centrosome (inferred); chromosome, telomeric region (inferred); nuclear body (inferred) | 17 | 51711267 | 51716806 | Dog | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18411752 | DCLRE1B | DNA cross-link repair 1B | ENCODES a protein that exhibits 5'-3' DNA exonuclease activity (inferred); 5'-3' exonuclease activity (inferred); beta-lactamase activity (inferred); INVOLVED IN DNA damage response (inferred); DNA repair (inferred); double-strand break repair via nonhomologous end joining (inferred); ASSOCIATED WIT H Autosomal Recessive Dyskeratosis Congenita 8 (ortholog); Fanconi anemia complementation group C (ortholog); Hoyeraal-Hreidarsson Syndrome (ortholog); FOUND IN centrosome (inferred); chromosome, telomeric region (inferred); nuclear body (inferred) | | | | Green Monkey | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626065488 | Dclre1b | DNA cross-link repair 1B | ENCODES a protein that exhibits 5'-3' exonuclease activity (ortholog); beta-lactamase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN interstrand cross-link repair (ortholog); protection from non-homologous end joining at telomere (ortholog); telomere capping (ortholog ); ASSOCIATED WITH Autosomal Recessive Dyskeratosis Congenita 8 (ortholog); Fanconi anemia complementation group C (ortholog); Hoyeraal-Hreidarsson Syndrome (ortholog); FOUND IN centrosome (ortholog); chromosome, telomeric region (ortholog); nuclear body (ortholog) | | | | Black Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239646 | dclre1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14025101 | DCLRE1B | DNA cross-link repair 1B | ENCODES a protein that exhibits 5'-3' exonuclease activity (inferred); beta-lactamase activity (inferred); exonuclease activity (inferred); INVOLVED IN DNA damage response (inferred); DNA repair (inferred); interstrand cross-link repair (inferred); ASSOCIATED WITH Autosomal Recessive Dyskeratosis Co ngenita 8 (ortholog); Fanconi anemia complementation group C (ortholog); Hoyeraal-Hreidarsson Syndrome (ortholog); FOUND IN centrosome (inferred); chromosome, telomeric region (inferred); nuclear body (inferred) | | | | Pig | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258821 | dclre1b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 7677982 | Dclre1b-ps1 | DNA cross-link repair 1B, pseudogene 1 | | 13 | 71269008 | 71274811 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 12597998 | Hipk1 | homeodomain interacting protein kinase 1 | ENCODES a protein that exhibits 5'-3' DNA exonuclease activity (inferred); 5'-3' exonuclease activity (inferred); ATP binding (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN centrosome (inferred); chromosome, telomeric region (inferred); cytoplasm (inferred) | NW_004936690 | 2293740 | 2353450 | Squirrel | 80 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935631 | Hipk1 | homeodomain interacting protein kinase 1 | ENCODES a protein that exhibits 5'-3' DNA exonuclease activity (inferred); 5'-3' exonuclease activity (inferred); ATP binding (inferred); INVOLVED IN adherens junction assembly (ortholog); anterior/posterior pattern specification (ortholog); embryonic camera-type eye morphogenesis (ortholog); ASSOCI ATED WITH acute kidney failure (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN cytosol (ortholog); nuclear speck (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 64 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |