| 621686 | Dab2ip | DAB2 interacting protein | ENCODES a protein that exhibits GTPase activator activity; 14-3-3 protein binding (ortholog); death receptor binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus; negative regulation of cell growth; negative regulation of epidermal growth factor receptor signaling pa thway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); atherosclerosis (ortholog); carotid artery occlusion (ortholog); FOUND IN AIP1-IRE1 complex (ortholog); axon (ortholog); cerebellar mossy fiber (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 3 | 39312745 | 39483730 | Rat | 416 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732352 | DAB2IP | DAB2 interacting protein | DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OM IM, May 2010] | 9 | 121567074 | 121785530 | Human | 283 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1331914 | Dab2ip | disabled 2 interacting protein | Enables protein kinase binding activity. Involved in several processes, including cellular response to cytokine stimulus; neurogenesis; and regulation of signal transduction. Located in axon; cytoplasm; and neuronal cell body membrane. Part of AIP1-IRE1 complex. Is expressed in cartilage; telencepha lon; and trigeminal ganglion. Human ortholog(s) of this gene implicated in artery disease (multiple); lung cancer; prostate cancer; and stomach cancer. Orthologous to human DAB2IP (DAB2 interacting protein). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 35448285 | 35621006 | Mouse | 344 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9021239 | Dab2ip | DAB2 interacting protein | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); death receptor binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN cell motility involved in cerebral cortex radial glia guided migration (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to interleukin-1 (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); atherosclerosis (ortholog); carotid artery occlusion (ortholog); FOUND IN AIP1-IRE1 complex (ortholog); axon (ortholog); cerebellar mossy fiber (ortholog) | NW_004955419 | 6229437 | 6416619 | Chinchilla | 152 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11891252 | DAB2IP | DAB2 interacting protein | ENCODES a protein that exhibits GTPase activator activity (ortholog); Toll-like receptor 4 binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); negative regulation of cell growth (ortholog); negative regulation of epidermal growth factor receptor signalin g pathway (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); atherosclerosis (ortholog); carotid artery occlusion (ortholog); FOUND IN AIP1-IRE1 complex (inferred); axon (inferred); cerebellar mossy fiber (inferred) | 9 | 92696798 | 92912425 | Bonobo | 134 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12354267 | DAB2IP | DAB2 interacting protein | ENCODES a protein that exhibits GTPase activator activity (ortholog); Toll-like receptor 4 binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); negative regulation of cell growth (ortholog); negative regulation of epidermal growth factor receptor signalin g pathway (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); atherosclerosis (ortholog); carotid artery occlusion (ortholog); FOUND IN AIP1-IRE1 complex (inferred); axon (inferred); cerebellar mossy fiber (inferred) | 9 | 60725887 | 60918242 | Dog | 136 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12671594 | Dab2ip | DAB2 interacting protein | ENCODES a protein that exhibits GTPase activator activity (ortholog); Toll-like receptor 4 binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); negative regulation of cell growth (ortholog); negative regulation of epidermal growth factor receptor signalin g pathway (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); atherosclerosis (ortholog); carotid artery occlusion (ortholog); FOUND IN AIP1-IRE1 complex (inferred); axon (inferred); cerebellar mossy fiber (inferred) | NW_004936487 | 10056809 | 10243021 | Squirrel | 135 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18476525 | DAB2IP | DAB2 interacting protein | ENCODES a protein that exhibits GTPase activator activity (ortholog); Toll-like receptor 4 binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); negative regulation of cell growth (ortholog); negative regulation of epidermal growth factor receptor signalin g pathway (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); atherosclerosis (ortholog); carotid artery occlusion (ortholog); FOUND IN AIP1-IRE1 complex (inferred); axon (inferred); cerebellar mossy fiber (inferred) | | | | Green Monkey | 134 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248848 | dab2ip | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626132209 | Dab2ip | DAB2 interacting protein | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); death receptor binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN cell motility involved in cerebral cortex radial glia guided migration (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to interleukin-1 (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); atherosclerosis (ortholog); carotid artery occlusion (ortholog); FOUND IN AIP1-IRE1 complex (ortholog); axon (ortholog); cerebellar mossy fiber (ortholog) | | | | Black Rat | 152 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14262661 | DAB2IP | DAB2 interacting protein | ENCODES a protein that exhibits GTPase activator activity (ortholog); Toll-like receptor 4 binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); negative regulation of cell growth (ortholog); negative regulation of epidermal growth factor receptor signalin g pathway (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); atherosclerosis (ortholog); carotid artery occlusion (ortholog); FOUND IN AIP1-IRE1 complex (inferred); axon (inferred); cerebellar mossy fiber (inferred); INTERACTS WITH ammonia | | | | Pig | 135 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920916 | Dab2ip | DAB2 interacting protein | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); death receptor binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN cell motility involved in cerebral cortex radial glia guided migration (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to interleukin-1 (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); atherosclerosis (ortholog); carotid artery occlusion (ortholog); FOUND IN AIP1-IRE1 complex (ortholog); axon (ortholog); cerebellar mossy fiber (ortholog) | | | | Naked Mole-Rat | 153 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248849 | dab2ip.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468769 | dab2ip.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1587193 | Dab2ip-ps1 | DAB2 interacting protein, pseudogene 1 | | 4 | 79169195 | 79175653 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |