| 620137 | Cx3cr1 | C-X3-C motif chemokine receptor 1 | ENCODES a protein that exhibits C-X3-C chemokine receptor activity; chemokine receptor activity; C-X3-C chemokine binding (ortholog); INVOLVED IN autocrine signaling; cell chemotaxis; cell-cell adhesion; PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; ASSOC IATED WITH anti-basement membrane glomerulonephritis; borna disease; Chronic Mesangial Proliferative Glomerulonephritis; FOUND IN cell surface; dendritic tree; neuronal cell body membrane; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil; acetamide | 8 | 128661294 | 128679048 | Rat | 321 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1352124 | CX3CR1 | C-X3-C motif chemokine receptor 1 | Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 in fection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] | 3 | 39263494 | 39292966 | Human | 357 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552004 | Cx3cr1 | C-X3-C motif chemokine receptor 1 | Enables C-X3-C chemokine binding activity and C-X3-C chemokine receptor activity. Involved in several processes, including antifungal innate immune response; central nervous system development; and synapse organization. Located in cell surface. Is expressed in several structures, including brain; co lon; genitourinary system; head mesenchyme; and meninges. Used to study age related macular degeneration 12. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif chemokine receptor 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 119877749 | 119897362 | Mouse | 428 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8783087 | Cx3cr1 | C-X3-C motif chemokine receptor 1 | ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); C-X3-C chemokine receptor activity (ortholog); chemokine receptor activity (ortholog); INVOLVED IN adaptive immune response (ortholog); antifungal innate immune response (ortholog); autocrine signaling (ortholog); ASSOCIATED WITH a ge related macular degeneration 12 (ortholog); anti-basement membrane glomerulonephritis (ortholog); arteriosclerosis (ortholog); FOUND IN cell surface (ortholog); dendritic tree (ortholog); neuronal cell body membrane (ortholog) | NW_004955427 | 24691206 | 24705599 | Chinchilla | 165 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11785132 | CX3CR1 | C-X3-C motif chemokine receptor 1 | ENCODES a protein that exhibits C-X3-C chemokine receptor activity (ortholog); chemokine receptor activity (ortholog); INVOLVED IN autocrine signaling (ortholog); cell-cell adhesion (ortholog); cellular response to lipopolysaccharide (ortholog); ASSOCIATED WITH age related macular degeneration 12 (o rtholog); anti-basement membrane glomerulonephritis (ortholog); arteriosclerosis (ortholog); FOUND IN dendritic tree (ortholog); neuronal cell body membrane (ortholog); perinuclear region of cytoplasm (ortholog) | 3 | 39158346 | 39176604 | Bonobo | 179 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12280501 | CX3CR1 | C-X3-C motif chemokine receptor 1 | ENCODES a protein that exhibits C-X3-C chemokine receptor activity (ortholog); chemokine receptor activity (ortholog); INVOLVED IN autocrine signaling (ortholog); cell-cell adhesion (ortholog); cellular response to lipopolysaccharide (ortholog); ASSOCIATED WITH age related macular degeneration 12 (o rtholog); anti-basement membrane glomerulonephritis (ortholog); arteriosclerosis (ortholog); FOUND IN dendritic tree (ortholog); neuronal cell body membrane (ortholog); perinuclear region of cytoplasm (ortholog) | 23 | 8937069 | 8954738 | Dog | 177 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12708335 | Cx3cr1 | C-X3-C motif chemokine receptor 1 | ENCODES a protein that exhibits C-X3-C chemokine receptor activity (ortholog); chemokine receptor activity (ortholog); INVOLVED IN autocrine signaling (ortholog); cell-cell adhesion (ortholog); cellular response to lipopolysaccharide (ortholog); ASSOCIATED WITH age related macular degeneration 12 (o rtholog); anti-basement membrane glomerulonephritis (ortholog); arteriosclerosis (ortholog); FOUND IN dendritic tree (ortholog); neuronal cell body membrane (ortholog); perinuclear region of cytoplasm (ortholog) | NW_004936473 | 28508726 | 28535640 | Squirrel | 176 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18746275 | CX3CR1 | C-X3-C motif chemokine receptor 1 | ENCODES a protein that exhibits C-X3-C chemokine receptor activity (ortholog); chemokine receptor activity (ortholog); INVOLVED IN autocrine signaling (ortholog); cell-cell adhesion (ortholog); cellular response to lipopolysaccharide (ortholog); ASSOCIATED WITH age related macular degeneration 12 (o rtholog); anti-basement membrane glomerulonephritis (ortholog); arteriosclerosis (ortholog); FOUND IN dendritic tree (ortholog); neuronal cell body membrane (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Green Monkey | 179 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926225 | Cx3cr1 | C-X3-C motif chemokine receptor 1 | ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); C-X3-C chemokine receptor activity (ortholog); chemokine receptor activity (ortholog); INVOLVED IN antifungal innate immune response (ortholog); autocrine signaling (ortholog); brain development (ortholog); ASSOCIATED WITH age rela ted macular degeneration 12 (ortholog); anti-basement membrane glomerulonephritis (ortholog); arteriosclerosis (ortholog); FOUND IN cell surface (ortholog); dendritic tree (ortholog); neuronal cell body membrane (ortholog) | | | | Naked Mole-Rat | 174 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14238081 | CX3CR1 | C-X3-C motif chemokine receptor 1 | ENCODES a protein that exhibits C-X3-C chemokine receptor activity (ortholog); chemokine receptor activity (ortholog); INVOLVED IN autocrine signaling (ortholog); cell-cell adhesion (ortholog); cellular response to lipopolysaccharide (ortholog); ASSOCIATED WITH age related macular degeneration 12 (o rtholog); anti-basement membrane glomerulonephritis (ortholog); arteriosclerosis (ortholog); FOUND IN dendritic tree (ortholog); neuronal cell body membrane (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Pig | 176 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626037935 | Cx3cr1 | C-X3-C motif chemokine receptor 1 | ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); C-X3-C chemokine receptor activity (ortholog); chemokine receptor activity (ortholog); INVOLVED IN adaptive immune response (ortholog); antifungal innate immune response (ortholog); autocrine signaling (ortholog); ASSOCIATED WITH a ge related macular degeneration 12 (ortholog); anti-basement membrane glomerulonephritis (ortholog); arteriosclerosis (ortholog); FOUND IN cell surface (ortholog); dendritic tree (ortholog); neuronal cell body membrane (ortholog) | | | | Black Rat | 165 | symbol | gene, protein-coding, MODEL [RefSeq] |