| 61810 | Ctsk | cathepsin K | ENCODES a protein that exhibits collagen binding (ortholog); cysteine-type endopeptidase activity (ortholog); cysteine-type peptidase activity (ortholog); INVOLVED IN bone resorption; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; PARTICIPA TES IN rheumatoid arthritis pathway; Toll-like receptor signaling pathway; ASSOCIATED WITH Alveolar Bone Loss; Experimental Arthritis; intracranial aneurysm; FOUND IN extracellular space; external side of plasma membrane (ortholog); lysosome (ortholog); INTERACTS WITH (S)-amphetamine; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol | 2 | 185747548 | 185758512 | Rat | 303 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62102 | Ctsk | cathepsin K | This gene encodes a member of the cathepsin family of cysteine proteases that is highly expressed in osteoclasts and is involved in the degradation of collagen and other matrix proteins in bone. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme. Mice lacking the encoded protein exhibit phenotypic features of pycnodysostosis such as increased bone density and bone deformity, which become progressively more pronounced with age. [provided by RefSeq, Jan 2016] | 3 | 95406521 | 95416698 | Mouse | 439 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 734172 | CTSK | cathepsin K | The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of h uman breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013] | 1 | 150796208 | 150808260 | Human | 496 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8834702 | Ctsk | cathepsin K | ENCODES a protein that exhibits collagen binding (ortholog); cysteine-type endopeptidase activity (ortholog); cysteine-type peptidase activity (ortholog); INVOLVED IN bone resorption (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necr osis factor (ortholog); ASSOCIATED WITH Alveolar Bone Loss (ortholog); Desbuquois dysplasia (ortholog); Experimental Arthritis (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); lysosome (ortholog) | NW_004955588 | 149036 | 158093 | Chinchilla | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11901006 | CTSK | cathepsin K | ENCODES a protein that exhibits collagen binding (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN bone resorption (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necr osis factor (ortholog); ASSOCIATED WITH Alveolar Bone Loss (ortholog); Desbuquois dysplasia (ortholog); Experimental Arthritis (ortholog); FOUND IN extracellular space (ortholog) | 1 | 126146555 | 126158662 | Bonobo | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12059801 | CTSK | cathepsin K | ENCODES a protein that exhibits collagen binding (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN bone resorption (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necr osis factor (ortholog); ASSOCIATED WITH Alveolar Bone Loss (ortholog); Desbuquois dysplasia (ortholog); Experimental Arthritis (ortholog); FOUND IN extracellular space (ortholog); lysosome (ortholog); INTERACTS WITH masitinib | 17 | 59928725 | 59938293 | Dog | 63 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12644641 | Ctsk | cathepsin K | ENCODES a protein that exhibits collagen binding (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN bone resorption (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necr osis factor (ortholog); ASSOCIATED WITH Alveolar Bone Loss (ortholog); Desbuquois dysplasia (ortholog); Experimental Arthritis (ortholog); FOUND IN extracellular space (ortholog) | NW_004936580 | 1022762 | 1038020 | Squirrel | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18911041 | Ctsk | cathepsin K | ENCODES a protein that exhibits collagen binding (ortholog); cysteine-type endopeptidase activity (ortholog); fibronectin binding (ortholog); INVOLVED IN bone resorption (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necrosis factor ( ortholog); ASSOCIATED WITH Alveolar Bone Loss (ortholog); Desbuquois dysplasia (ortholog); Experimental Arthritis (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18710984 | CTSK | cathepsin K | ENCODES a protein that exhibits collagen binding (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN bone resorption (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necr osis factor (ortholog); ASSOCIATED WITH Alveolar Bone Loss (ortholog); Desbuquois dysplasia (ortholog); Experimental Arthritis (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626100977 | Ctsk | cathepsin K | ENCODES a protein that exhibits collagen binding (ortholog); cysteine-type endopeptidase activity (ortholog); cysteine-type peptidase activity (ortholog); INVOLVED IN bone resorption (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necr osis factor (ortholog); ASSOCIATED WITH Alveolar Bone Loss (ortholog); Desbuquois dysplasia (ortholog); Experimental Arthritis (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); lysosome (ortholog) | | | | Black Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 329332938 | ctsk | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14278128 | CTSK | cathepsin K | ENCODES a protein that exhibits collagen binding (inferred); cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN bone resorption (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necr osis factor (ortholog); ASSOCIATED WITH Alveolar Bone Loss (ortholog); Desbuquois dysplasia (ortholog); Experimental Arthritis (ortholog); FOUND IN extracellular space; lysosome | | | | Pig | 60 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 288075638 | ctsk.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862696 | ctsk.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626172087 | ctsk.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856092 | ctsk.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863529 | ctsk.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859316 | ctsk.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 284030265 | XB986811 [provisional:ctsk] | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 598152252 | CtsK2 | | | | | | Fly | | symbol | gene, null |
| 598151707 | CtsK2 | | | | | | Fly | | symbol | gene, null |
