CTSK (cathepsin K) - Rat Genome Database

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Gene: CTSK (cathepsin K) Canis lupus familiaris
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Symbol: CTSK
Name: cathepsin K
RGD ID: 12059801
Description: ENCODES a protein that exhibits collagen binding (ortholog); fibronectin binding (ortholog); proteoglycan binding (ortholog); INVOLVED IN bone resorption (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necrosis factor (ortholog); ASSOCIATED WITH Alveolar Bone Loss (ortholog); Experimental Arthritis (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); intracellular membrane-bounded organelle (ortholog); INTERACTS WITH masitinib
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cathepsin K (pycnodysostosis)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,928,725 - 59,938,293 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,929,287 - 59,938,507 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,375,185 - 59,382,593 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,945,042 - 60,954,711 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,945,043 - 61,028,017 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,774,900 - 59,782,304 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,859,083 - 59,866,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,587,454 - 60,594,862 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
masitinib  (EXP)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CTSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,928,725 - 59,938,293 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,929,287 - 59,938,507 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,375,185 - 59,382,593 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,945,042 - 60,954,711 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,945,043 - 61,028,017 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,774,900 - 59,782,304 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,859,083 - 59,866,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,587,454 - 60,594,862 (-)NCBIUU_Cfam_GSD_1.0
CTSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,796,208 - 150,808,260 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1150,794,880 - 150,809,577 (-)EnsemblGRCh38hg38GRCh38
GRCh371150,768,684 - 150,780,736 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,035,311 - 149,047,436 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,581,759 - 147,593,885NCBI
Celera1123,884,715 - 123,896,850 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,146,309 - 122,158,545 (-)NCBIHuRef
CHM1_11152,164,010 - 152,176,259 (-)NCBICHM1_1
T2T-CHM13v2.01149,919,861 - 149,931,947 (-)NCBIT2T-CHM13v2.0
Ctsk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,406,521 - 95,416,698 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,406,567 - 95,416,673 (+)EnsemblGRCm39 Ensembl
GRCm38395,499,210 - 95,509,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,499,256 - 95,509,362 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,303,208 - 95,313,284 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,584,690 - 95,594,766 (+)NCBIMGSCv36mm8
Celera396,930,391 - 96,940,481 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
Ctsk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,747,548 - 185,758,512 (+)NCBIGRCr8
mRatBN7.22183,058,586 - 183,069,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,058,569 - 183,069,550 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,723,332 - 190,734,303 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,518,632 - 188,529,601 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,355,824 - 183,366,795 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,655,469 - 196,666,447 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,655,469 - 196,666,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02216,154,168 - 216,164,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,394,854 - 190,405,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,357,607 - 190,368,421 (+)NCBI
Celera2175,591,773 - 175,602,552 (+)NCBICelera
Cytogenetic Map2q34NCBI
Ctsk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955588148,748 - 158,093 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955588149,036 - 158,093 (-)NCBIChiLan1.0ChiLan1.0
CTSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,022,154 - 99,036,182 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,777,588 - 98,789,833 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01126,146,555 - 126,158,662 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11129,795,966 - 129,808,316 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,795,966 - 129,808,316 (-)Ensemblpanpan1.1panPan2
Ctsk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,992,384 - 22,005,049 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365801,022,762 - 1,034,984 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365801,022,762 - 1,038,020 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,391,428 - 98,404,961 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,389,459 - 98,404,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,639,430 - 107,653,109 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CTSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603812,471,719 - 12,484,331 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477219,015,835 - 19,025,588 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477219,013,189 - 19,026,756 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CTSK
62 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 10 10 6
Low 4 2 8
Below cutoff 2

Sequence


RefSeq Acc Id: ENSCAFT00000019202   ⟹   ENSCAFP00000017808
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1759,929,287 - 59,938,507 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845034366   ⟹   ENSCAFP00845026906
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1760,945,043 - 61,028,017 (-)Ensembl
RefSeq Acc Id: NM_001033996   ⟹   NP_001029168
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11759,929,302 - 59,936,710 (-)NCBI
Dog10K_Boxer_Tasha1759,375,185 - 59,382,593 (-)NCBI
ROS_Cfam_1.01760,945,619 - 60,953,031 (-)NCBI
UMICH_Zoey_3.11759,774,900 - 59,782,304 (-)NCBI
UNSW_CanFamBas_1.01759,859,083 - 59,866,492 (-)NCBI
UU_Cfam_GSD_1.01760,587,454 - 60,594,862 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038690501   ⟹   XP_038546429
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01760,945,042 - 60,954,711 (-)NCBI
RefSeq Acc Id: XM_038690502   ⟹   XP_038546430
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01760,945,042 - 60,954,703 (-)NCBI
RefSeq Acc Id: NP_001029168   ⟸   NM_001033996
- Peptide Label: precursor
- UniProtKB: Q3ZKN1 (UniProtKB/Swiss-Prot),   A0A8C0R469 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000017808   ⟸   ENSCAFT00000019202
RefSeq Acc Id: XP_038546429   ⟸   XM_038690501
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038546430   ⟸   XM_038690502
- Peptide Label: isoform X2
- UniProtKB: Q3ZKN1 (UniProtKB/Swiss-Prot),   A0A8C0R469 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845026906   ⟸   ENSCAFT00845034366

Promoters
RGD ID:13686392
Promoter ID:EPDNEW_C4462
Type:initiation region
Name:CTSK_1
Description:cathepsin K
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11759,936,697 - 59,936,757EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012093 Ensembl
  ENSCAFG00000012149 UniProtKB/Swiss-Prot
  ENSCAFG00030006444 UniProtKB/Swiss-Prot
  ENSCAFG00040011336 UniProtKB/Swiss-Prot
  ENSCAFG00845019461 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000019492.6 UniProtKB/Swiss-Prot
  ENSCAFT00030011860.1 UniProtKB/Swiss-Prot
  ENSCAFT00040021021.1 UniProtKB/Swiss-Prot
  ENSCAFT00845034366 ENTREZGENE
  ENSCAFT00845034366.1 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_asp_AS UniProtKB/Swiss-Prot
  Pept_cys_AS UniProtKB/Swiss-Prot
  Pept_his_AS UniProtKB/Swiss-Prot
  Peptidase_C1A UniProtKB/Swiss-Prot
  Peptidase_C1A_C UniProtKB/Swiss-Prot
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot
  Prot_inhib_I29 UniProtKB/Swiss-Prot
KEGG Report cfa:608843 UniProtKB/Swiss-Prot
NCBI Gene CTSK ENTREZGENE
PANTHER CATHEPSIN K UniProtKB/Swiss-Prot
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot
  Peptidase_C1 UniProtKB/Swiss-Prot
PRINTS PAPAIN UniProtKB/Swiss-Prot
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot
SMART Inhibitor_I29 UniProtKB/Swiss-Prot
  Pept_C1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
UniProt A0A8C0R469 ENTREZGENE
  CATK_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:39714 ENTREZGENE