| 1351144 | CSTF2 | cleavage stimulation factor subunit 2 | This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untransl ated region of mRNAs. [provided by RefSeq, Jul 2008] | X | 100820391 | 100841520 | Human | 117 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1596566 | Cstf2 | cleavage stimulation factor subunit 2 | ENCODES a protein that exhibits RNA binding (ortholog); INVOLVED IN cellular response to nerve growth factor stimulus; mRNA 3'-end processing (ortholog); regulation of mRNA 3'-end processing (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination p athway; mRNA decay pathway; ASSOCIATED WITH X-Linked Intellectual Developmental Disorder 113 (ortholog); FOUND IN cleavage body (ortholog); mRNA cleavage and polyadenylation specificity factor complex (ortholog); nuclear body (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; 6-propyl-2-thiouracil | X | 101546809 | 101572760 | Rat | 106 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1623038 | Cstf2 | cleavage stimulation factor, 3' pre-RNA subunit 2 | Predicted to enable mRNA binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be located in cleavage body. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex ventricula r layer; and cortical plate. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human CSTF2 (cleavage stimulation factor subunit 2). [provided by Alliance of Genome Resources, Jul 2025] | X | 132959925 | 132987571 | Mouse | 123 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8805981 | Cstf2 | cleavage stimulation factor subunit 2 | ENCODES a protein that exhibits RNA binding (ortholog); INVOLVED IN cellular response to nerve growth factor stimulus (ortholog); mRNA 3'-end processing (ortholog); regulation of mRNA 3'-end processing (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription te rmination pathway; ASSOCIATED WITH X-Linked Intellectual Developmental Disorder 113 (ortholog); FOUND IN cleavage body (ortholog); mRNA cleavage and polyadenylation specificity factor complex (ortholog); mRNA cleavage stimulating factor complex (ortholog) | NW_004955503 | 6949901 | 6971281 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12045929 | CSTF2 | cleavage stimulation factor subunit 2 | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN cellular response to nerve growth factor stimulus (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIA TED WITH X-Linked Intellectual Developmental Disorder 113 (ortholog); FOUND IN cleavage body (inferred); mRNA cleavage and polyadenylation specificity factor complex (inferred); nuclear body (inferred) | X | 90023054 | 90046229 | Bonobo | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12339758 | CSTF2 | cleavage stimulation factor subunit 2 | ENCODES a protein that exhibits nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN cellular response to nerve growth factor stimulus (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH X-Linked Intelle ctual Developmental Disorder 113 (ortholog); FOUND IN cleavage body (inferred); mRNA cleavage and polyadenylation specificity factor complex (inferred); nuclear body (inferred) | X | 74758399 | 74782470 | Dog | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12453060 | Cstf2 | cleavage stimulation factor subunit 2 | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN cellular response to nerve growth factor stimulus (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIA TED WITH X-Linked Intellectual Developmental Disorder 113 (ortholog); FOUND IN cleavage body (inferred); mRNA cleavage and polyadenylation specificity factor complex (inferred); nuclear body (inferred) | NW_004936584 | 6042785 | 6066758 | Squirrel | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13960009 | CSTF2 | cleavage stimulation factor subunit 2 | ENCODES a protein that exhibits nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN cellular response to nerve growth factor stimulus (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH X-Linked Intelle ctual Developmental Disorder 113 (ortholog); FOUND IN cleavage body (inferred); mRNA cleavage and polyadenylation specificity factor complex (inferred); nuclear body (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625871822 | Cstf2 | cleavage stimulation factor subunit 2 | ENCODES a protein that exhibits RNA binding (ortholog); INVOLVED IN cellular response to nerve growth factor stimulus (ortholog); mRNA 3'-end processing (ortholog); regulation of mRNA 3'-end processing (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription te rmination pathway; ASSOCIATED WITH X-Linked Intellectual Developmental Disorder 113 (ortholog); FOUND IN cleavage body (ortholog); mRNA cleavage and polyadenylation specificity factor complex (ortholog); mRNA cleavage stimulating factor complex (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18787350 | CSTF2 | cleavage stimulation factor subunit 2 | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN cellular response to nerve growth factor stimulus (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; ASSOCIA TED WITH X-Linked Intellectual Developmental Disorder 113 (ortholog); FOUND IN cleavage body (inferred); mRNA cleavage and polyadenylation specificity factor complex (inferred); nuclear body (inferred) | | | | Green Monkey | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904685 | Cstf2 | cleavage stimulation factor subunit 2 | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN cellular response to nerve growth factor stimulus (ortholog); regulation of mRNA 3'-end processing (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymer ase II transcription termination pathway; ASSOCIATED WITH X-Linked Intellectual Developmental Disorder 113 (ortholog); FOUND IN cleavage body (ortholog); mRNA cleavage stimulating factor complex (ortholog); nuclear body (ortholog) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251863 | cstf2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155251864 | cstf2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1310026 | Cstf2t | cleavage stimulation factor subunit 2, tau variant | ENCODES a protein that exhibits RNA binding (ortholog); INVOLVED IN mRNA 3'-end processing (inferred); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; mRNA decay pathway; FOUND IN nucleus (inferred); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8- tetrachlorodibenzodioxine; aflatoxin B1 | 1 | 238366042 | 238369608 | Rat | 82 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1320690 | CSTF2T | cleavage stimulation factor subunit 2 tau variant | Enables RNA binding activity. Predicted to be involved in mRNA 3'-end processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 10 | 51695486 | 51699595 | Human | 85 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1320691 | Cstf2t | cleavage stimulation factor, 3' pre-RNA subunit 2, tau | Enables RNA binding activity. Predicted to act upstream of or within mRNA 3'-end processing. Predicted to be located in nucleoplasm. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in brain and spinal cord. Orthologous to human CSTF2 ght:700;'>CSTF2T (cleavage stimulation factor subunit 2 tau variant). [provided by Alliance of Genome Resources, Apr 2025] | 19 | 31060241 | 31063992 | Mouse | 95 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8837964 | Cstf2t | cleavage stimulation factor subunit 2 tau variant | ENCODES a protein that exhibits RNA binding (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway | NW_004955425 | 6830775 | 6834799 | Chinchilla | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11712205 | CSTF2T | cleavage stimulation factor subunit 2 tau variant | ENCODES a protein that exhibits RNA binding (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway | 10 | 48342491 | 48346810 | Bonobo | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12649520 | Cstf2t | cleavage stimulation factor subunit 2 tau variant | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN mRNA 3'-end processing (inferred); mRNA processing (inferred); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; FOUND IN mRNA cleavage and polyadenylation specificity factor complex (inferred); nucleus (inferred) | NW_004936787 | 838153 | 842118 | Squirrel | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 40909951 | CSTF2T | cleavage stimulation factor subunit 2 tau variant | ENCODES a protein that exhibits nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN mRNA 3'-end processing (inferred); mRNA processing (inferred); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; FOUND IN nucleus (inferred) | | | | Dog | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625883441 | Cstf2t | cleavage stimulation factor subunit 2 tau variant | ENCODES a protein that exhibits RNA binding (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway | | | | Black Rat | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14196699 | CSTF2T | cleavage stimulation factor subunit 2 tau variant | ENCODES a protein that exhibits nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN mRNA 3'-end processing (inferred); mRNA processing (inferred); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; FOUND IN nucleus (inferred); IN TERACTS WITH deoxynivalenol | | | | Pig | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920229 | Cstf2t | cleavage stimulation factor subunit 2 tau variant | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN mRNA 3'-end processing (inferred); mRNA processing (inferred); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; FOUND IN mRNA cleavage and polyadenylation specificity factor complex (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 598130147 | CSTF2T | cleavage stimulation factor subunit 2 tau variant | ENCODES a protein that exhibits mRNA binding (inferred); nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN mRNA 3'-end processing (inferred); mRNA processing (inferred); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; FOUND IN mRNA cleavage and polyadenylation specificity factor complex (inferred); nucleus (inferred) | | | | Green Monkey | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 19259624 | CSTF2T | cleavage stimulation factor subunit 2 tau variant | | | | | Dog | | symbol | gene, protein-coding |
| 1314208 | CSTF3 | cleavage stimulation factor subunit 3 | The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The e ncoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] | 11 | 33084584 | 33161480 | Human | 118 | description | gene, protein-coding, REVIEWED [RefSeq] |