| 1311404 | Cops8 | COP9 signalosome subunit 8 | INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); negative regulation of cell population proliferation (ortholog); protein deneddylation (ortholog); FOUND IN COP9 signalosome (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine ; bisphenol A; flutamide | 9 | 98655031 | 98664861 | Rat | 103 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1322849 | COPS8 | COP9 signalosome subunit 8 | The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S prote asome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] | 2 | 237085889 | 237100474 | Human | 111 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1322850 | Cops8 | COP9 signalosome subunit 8 | Predicted to be involved in activation of NF-kappaB-inducing kinase activity; negative regulation of cell population proliferation; and protein modification process. Located in nucleus. Part of COP9 signalosome. Is expressed in several structures, including early embryo; liver; and oocyte. Orthologo us to human COPS8 (COP9 signalosome subunit 8). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 90531147 | 90541063 | Mouse | 119 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9002394 | Cops8 | COP9 signalosome subunit 8 | INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); negative regulation of cell population proliferation (ortholog); protein deneddylation (ortholog); FOUND IN COP9 signalosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955542 | 3129184 | 3140232 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11776506 | COPS8 | COP9 signalosome subunit 8 | INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); protein phosphorylation (ortholog); FOUND IN COP9 signalosome (inferred); cytoplasm (inferred); cytosol (inferred) | 2B | 124315423 | 124328830 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12095476 | COPS8 | COP9 signalosome subunit 8 | INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); negative regulation of cell population proliferation (ortholog); protein phosphorylation (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); perinuclear region of cytoplasm (ortholog) | 25 | 47783241 | 47796806 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12601129 | Cops8 | COP9 signalosome subunit 8 | INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); protein phosphorylation (ortholog); FOUND IN COP9 signalosome (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936525 | 1168995 | 1180763 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18479370 | COPS8 | COP9 signalosome subunit 8 | INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); negative regulation of cell population proliferation (ortholog); protein phosphorylation (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Green Monkey | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625882344 | Cops8 | COP9 signalosome subunit 8 | INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); negative regulation of cell population proliferation (ortholog); protein deneddylation (ortholog); FOUND IN COP9 signalosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237708 | cops8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18927740 | Cops8 | COP9 signalosome subunit 8 | INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); negative regulation of cell population proliferation (ortholog); protein phosphorylation (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14208807 | COPS8 | COP9 signalosome subunit 8 | INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); protein phosphorylation (ortholog); FOUND IN COP9 signalosome (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Pig | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237709 | cops8.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258140 | cops8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38650831 | COPS8-DT | COPS8 divergent transcript | INTERACTS WITH okadaic acid | 2 | 236910771 | 237085821 | Human | 1 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1561908 | Cops8-ps2 | COP9 signalosome subunit 8, pseudogene 1 | | 13 | 78946826 | 78947443 | Rat | | symbol , PhenoGen , old_gene_symbol | gene, pseudo, MODEL [RefSeq] |
| 41257153 | Cops8-ps3 | COP9 signalosome subunit 8, pseudogene 2 | | 14 | 59977694 | 59978351 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 2323522 | Cops8-ps5 | COP9 signalosome subunit 8, pseudogene 4 | | 1 | 220355833 | 220356359 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 7254218 | COPS8P1 | COP9 signalosome subunit 8 pseudogene 1 | | X | 86798401 | 86799282 | Human | | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7256207 | COPS8P2 | COP9 signalosome subunit 8 pseudogene 2 | INTERACTS WITH methylparaben | 3 | 68144988 | 68145776 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10400331 | COPS8P3 | COP9 signalosome subunit 8 pseudogene 3 | | 11 | 78581675 | 78582156 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |