| 68432 | Cldn7 | claudin 7 | ENCODES a protein that exhibits cell adhesion molecule binding; protein domain specific binding; identical protein binding (ortholog); INVOLVED IN negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of protein-containing complex assembly; PARTICIPATES IN hepatitis C pathway; ASSOCIATED WITH Neoplasm Metastasis; allergic rhinitis (ortholog); COVID-19 (ortholog); FOUND IN basolateral plasma membrane; lateral plasma membrane; apicolateral plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 55188670 | 55190871 | Rat | 182 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 68646 | CLDN7 | claudin 7 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010] | 17 | 7259903 | 7263213 | Human | 180 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 68647 | Cldn7 | claudin 7 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed constitutively in the mammary epithelium throughout development, and might be involved in vesicle trafficking to the basolateral membrane. It is essential for NaCl homeostasis in distal nephrons. The knockout mice lacking this gene showed severe salt wasting, chronic dehydration, and growth retardation, and died within 12 days after birth. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010] | 11 | 69855605 | 69858712 | Mouse | 202 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8919204 | Cldn7 | claudin 7 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cell adhesion (ortholog); negative regulation of protein-containing complex assembly (ortholo g); ASSOCIATED WITH allergic rhinitis (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN apicolateral plasma membrane (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | NW_004955467 | 9652093 | 9654291 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11831240 | CLDN7 | claudin 7 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cell adhesion (ortholog); negative regulation of protein-containing complex assembly (ortholo g); ASSOCIATED WITH allergic rhinitis (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN basolateral plasma membrane (ortholog); lateral plasma membrane (ortholog) | 17 | 7289766 | 7292433 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12311924 | CLDN7 | claudin 7 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cell adhesion (ortholog); negative regulation of protein-containing complex assembly (ortholo g); ASSOCIATED WITH allergic rhinitis (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN basolateral plasma membrane (ortholog); lateral plasma membrane (ortholog) | 5 | 32223985 | 32225795 | Dog | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12605930 | Cldn7 | claudin 7 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cell adhesion (ortholog); negative regulation of protein-containing complex assembly (ortholo g); ASSOCIATED WITH allergic rhinitis (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN basolateral plasma membrane (ortholog); lateral plasma membrane (ortholog) | NW_004936595 | 550359 | 552214 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926487 | Cldn7 | claudin 7 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cell adhesion (ortholog); negative regulation of protein-containing complex assembly (ortholo g); ASSOCIATED WITH allergic rhinitis (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN basolateral plasma membrane (ortholog); lateral plasma membrane (ortholog) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625879959 | Cldn7 | claudin 7 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cell adhesion (ortholog); negative regulation of protein-containing complex assembly (ortholo g); ASSOCIATED WITH allergic rhinitis (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN apicolateral plasma membrane (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240736 | cldn7 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18783803 | CLDN7 | claudin 7 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cell adhesion (ortholog); negative regulation of protein-containing complex assembly (ortholo g); ASSOCIATED WITH allergic rhinitis (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN basolateral plasma membrane (ortholog); lateral plasma membrane (ortholog) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14146129 | CLDN7 | claudin 7 | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of cell adhesion (ortholog); negative regulation of protein-containing complex assembly (ortholo g); ASSOCIATED WITH allergic rhinitis (ortholog); COVID-19 (ortholog); Neoplasm Metastasis (ortholog); FOUND IN basolateral plasma membrane (ortholog); lateral plasma membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 36 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155240735 | cldn7.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231730 | cldn7.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 25824865 | CLDN7P1 | CLDN7 pseudogene 1 | | X | 40760913 | 40761491 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |