| 71081 | Cldn11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon ensheathment (ortholog); calcium-independent cell-cell adhesion (ortholog); cell adhesion (ortholog); PARTICIPATES IN hepatitis C pathway; ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodys trophy 22 (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (ortholog); basal part of cell (ortholog); bicellular tight junction (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 2 | 114136234 | 114149539 | Rat | 202 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732844 | CLDN11 | claudin 11 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010] | 3 | 170418868 | 170434691 | Human | 213 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737604 | Cldn11 | claudin 11 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of CNS (central nervous system) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. The basal cell tight junctions in stria vascularis are primarily composed of this protein, and the gene-null mice suffer severe deafness. This protein is also an obligatory protein for tight junction formation and barrier integrity in the testis and the gene deficiency results in loss of the Sertoli cell epithelial phenotype in the testis. [provided by RefSeq, Aug 2010] | 3 | 31204069 | 31218475 | Mouse | 229 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8802328 | Cldn11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (ortholog); basal part of cell (ortholog); bicellular tight junction (ortholog) | NW_004955420 | 580588 | 595052 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11886845 | CLDN11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog ); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (inferred); basal part of cell (inferred); bicellular tight junction (inferred) | 3 | 167432856 | 167448053 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12398087 | CLDN11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (ortholog); basal part of cell (ortholog); cell junction (ortholog) | 34 | 34912903 | 34929441 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12732055 | Cldn11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog ); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (inferred); basal part of cell (inferred); bicellular tight junction (inferred) | NW_004936593 | 2072368 | 2087820 | Squirrel | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257640 | cldn11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18692543 | CLDN11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog ); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (inferred); basal part of cell (inferred); bicellular tight junction (inferred) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14091010 | CLDN11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (inferred); structural molecule activity (inferred); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog ); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (inferred); basal part of cell (inferred); bicellular tight junction (inferred) | | | | Pig | 35 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18931671 | Cldn11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (ortholog); basal part of cell (ortholog); cell junction (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626084890 | Cldn11 | claudin 11 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN axon ensheathment (ortholog); cell adhesion (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); hypomyelinating leukodystrophy 22 (ortholog); Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN axon (ortholog); basal part of cell (ortholog); bicellular tight junction (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626469340 | cldn11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863137 | cldn11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864940 | cldn11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859140 | cldn11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860492 | cldn11.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626176647 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865344 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858841 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626181371 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626185114 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860729 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856018 | cldn11.S | | | | | | African Clawed Frog | | symbol | gene, null |
