| 2315 | Cd81 | Cd81 molecule | ENCODES a protein that exhibits cholesterol binding (ortholog); integrin binding (ortholog); MHC class II protein binding (ortholog); INVOLVED IN regulation of cell population proliferation; regulation of growth; CD4-positive, alpha-beta T cell costimulation (ortholog); PARTICIPATES IN B cell recept or signaling pathway; hepatitis C pathway; malaria pathway; ASSOCIATED WITH common variable immunodeficiency (ortholog); common variable immunodeficiency 6 (ortholog); hepatitis C (ortholog); FOUND IN apical plasma membrane; basal plasma membrane (ortholog); basolateral plasma membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol | 1 | 207665274 | 207681094 | Rat | 237 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 731700 | CD81 | CD81 molecule | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] | 11 | 2376180 | 2397397 | Human | 257 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 731701 | Cd81 | CD81 antigen | Predicted to enable cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of receptor clustering; and syncytium formation by plasma membrane fusion. Acts ups tream of or within regulation of cell motility. Located in membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in common variable immunodeficiency 6. Orthologous to human CD81 (CD81 molecule). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 142606487 | 142621667 | Mouse | 299 | symbol , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8856829 | Cd81 | CD81 molecule | ENCODES a protein that exhibits cholesterol binding (ortholog); integrin binding (ortholog); MHC class II protein binding (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell costimulation (ortholog); cellular response to low-density lipoprotein particle stimulus (ortholog); humoral immune respon se mediated by circulating immunoglobulin (ortholog); ASSOCIATED WITH common variable immunodeficiency (ortholog); common variable immunodeficiency 6 (ortholog); hepatitis C (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | NW_004955422 | 14155682 | 14175181 | Chinchilla | 77 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11965783 | CD81 | CD81 molecule | ENCODES a protein that exhibits cholesterol binding (inferred); integrin binding (inferred); lipid binding (inferred); INVOLVED IN regulation of cell motility (ortholog); regulation of cell population proliferation (ortholog); regulation of growth (ortholog); ASSOCIATED WITH common variable immunode ficiency (ortholog); common variable immunodeficiency 6 (ortholog); hepatitis C (ortholog); FOUND IN apical plasma membrane (ortholog) | 11 | 2400503 | 2421132 | Bonobo | 81 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12223066 | CD81 | CD81 molecule | ENCODES a protein that exhibits cholesterol binding (ortholog); integrin binding (ortholog); MHC class II protein binding (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell costimulation (ortholog); cellular response to low-density lipoprotein particle stimulus (ortholog); humoral immune respon se mediated by circulating immunoglobulin (ortholog); ASSOCIATED WITH common variable immunodeficiency (ortholog); common variable immunodeficiency 6 (ortholog); hepatitis C (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); extracellular exosome (ortholog) | 18 | 46466484 | 46474236 | Dog | 84 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12727522 | Cd81 | CD81 molecule | ENCODES a protein that exhibits cholesterol binding (inferred); integrin binding (inferred); lipid binding (inferred); INVOLVED IN regulation of cell motility (ortholog); regulation of cell population proliferation (ortholog); regulation of growth (ortholog); ASSOCIATED WITH common variable immunode ficiency (ortholog); common variable immunodeficiency 6 (ortholog); hepatitis C (ortholog); FOUND IN apical plasma membrane (ortholog) | NW_004936794 | 664089 | 670294 | Squirrel | 79 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14125860 | CD81 | CD81 molecule | ENCODES a protein that exhibits cholesterol binding (inferred); integrin binding (inferred); lipid binding (inferred); INVOLVED IN regulation of cell motility (ortholog); regulation of cell population proliferation (ortholog); regulation of growth (ortholog); ASSOCIATED WITH common variable immunode ficiency (ortholog); common variable immunodeficiency 6 (ortholog); hepatitis C (ortholog); FOUND IN apical plasma membrane (ortholog) | | | | Pig | 81 | symbol , old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18904525 | Cd81 | CD81 molecule | ENCODES a protein that exhibits cholesterol binding (ortholog); integrin binding (ortholog); MHC class II protein binding (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell costimulation (ortholog); cellular response to low-density lipoprotein particle stimulus (ortholog); humoral immune respon se mediated by circulating immunoglobulin (ortholog); ASSOCIATED WITH common variable immunodeficiency (ortholog); common variable immunodeficiency 6 (ortholog); hepatitis C (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); extracellular exosome (ortholog) | | | | Naked Mole-Rat | 83 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155234096 | cd81 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626126422 | Cd81 | CD81 molecule | ENCODES a protein that exhibits cholesterol binding (ortholog); integrin binding (ortholog); MHC class II protein binding (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell costimulation (ortholog); cellular response to low-density lipoprotein particle stimulus (ortholog); humoral immune respon se mediated by circulating immunoglobulin (ortholog); ASSOCIATED WITH common variable immunodeficiency (ortholog); common variable immunodeficiency 6 (ortholog); hepatitis C (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog) | | | | Black Rat | 77 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18586370 | CD81 | CD81 molecule | ENCODES a protein that exhibits cholesterol binding (inferred); integrin binding (inferred); lipid binding (inferred); INVOLVED IN regulation of cell motility (ortholog); regulation of cell population proliferation (ortholog); regulation of growth (ortholog); ASSOCIATED WITH common variable immunode ficiency (ortholog); common variable immunodeficiency 6 (ortholog); hepatitis C (ortholog); FOUND IN apical plasma membrane (ortholog) | | | | Green Monkey | 81 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155234095 | cd81.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256267 | cd81.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 7391663 | CD81-AS1 | CD81 antisense RNA 1 | INTERACTS WITH aflatoxin B1; Aflatoxin B2 alpha; benzo[a]pyrene | 11 | 2328749 | 2377992 | Human | 4 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1322991 | IGSF8 | immunoglobulin superfamily member 8 | This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 '>CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] | 1 | 160091339 | 160099468 | Human | 79 | old_gene_name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1322992 | Igsf8 | immunoglobulin superfamily, member 8 | Involved in modulation of chemical synaptic transmission. Acts upstream of or within regulation of cell motility. Located in axon and synapse. Is expressed in several structures, including branchial arch; cardiac muscle tissue; central nervous system; epithelium; and sensory organ. Orthologous to hu man IGSF8 (immunoglobulin superfamily member 8). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 172139934 | 172147410 | Mouse | 77 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1319228 | CD19 | CD19 molecule | This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. T he protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020] | 16 | 28931971 | 28939342 | Human | 169 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 733907 | SNX16 | sorting nexin 16 | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule form ation, cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. [provided by RefSeq, Jan 2017] | 8 | 81799583 | 81842185 | Human | 103 | description | gene, protein-coding, REVIEWED [RefSeq] |
