| 1553554 | Cd274 | CD274 antigen | The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domai ns. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015] | 19 | 29339428 | 29365495 | Mouse | 405 | symbol , PhenoGen , name | gene, protein-coding, REVIEWED [RefSeq] |
| 1566211 | Cd274 | CD274 molecule | ENCODES a protein that exhibits receptor ligand activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN positive regulation of cell migration; positive regulation of T cell proliferation; cell surface receptor signaling pathway (ortholog); ASSOCIATED WITH Corneal Graft Reject ion; Experimental Mammary Neoplasms; periodontitis; FOUND IN cell surface; early endosome membrane (ortholog); external side of plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate | 1 | 236526215 | 236549956 | Rat | 314 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1605684 | CD274 | CD274 molecule | This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] | 9 | 5450542 | 5470554 | Human | 325 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8912452 | Cd274 | CD274 molecule | ENCODES a protein that exhibits receptor ligand activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); immune response (ortholog); negative regulation of activated T cell proliferation (ortholog); ASSOCIATED WITH acute myoc arditis (ortholog); adult T-cell leukemia/lymphoma (ortholog); allergic disease (ortholog); FOUND IN cell surface (ortholog); early endosome membrane (ortholog); external side of plasma membrane (ortholog) | NW_004955434 | 9487309 | 9508366 | Chinchilla | 120 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11982629 | CD274 | CD274 molecule | ENCODES a protein that exhibits receptor ligand activity (inferred); transcription coactivator activity (inferred); INVOLVED IN negative regulation of T cell proliferation (ortholog); positive regulation of cell migration (ortholog); positive regulation of T cell apoptotic process (ortholog); ASSOCI ATED WITH acute myocarditis (ortholog); adult T-cell leukemia/lymphoma (ortholog); allergic disease (ortholog); FOUND IN cell surface (ortholog); nucleus (ortholog) | 9 | 5269270 | 5289629 | Bonobo | 132 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12115381 | CD274 | CD274 molecule | ENCODES a protein that exhibits receptor ligand activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN negative regulation of activated T cell proliferation (ortholog); negative regulation of CD4-positive, alpha-beta T cell proliferation (ortholog); negative regulation of CD 8-positive, alpha-beta T cell activation (ortholog); ASSOCIATED WITH acute myocarditis (ortholog); adult T-cell leukemia/lymphoma (ortholog); allergic disease (ortholog); FOUND IN cell surface (ortholog); extracellular exosome (ortholog); nuclear speck (ortholog) | 1 | 93461735 | 93605772 | Dog | 128 | symbol , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12690588 | Cd274 | CD274 molecule | ENCODES a protein that exhibits receptor ligand activity (inferred); transcription coactivator activity (inferred); INVOLVED IN negative regulation of T cell proliferation (ortholog); positive regulation of cell migration (ortholog); positive regulation of T cell apoptotic process (ortholog); ASSOCI ATED WITH acute myocarditis (ortholog); adult T-cell leukemia/lymphoma (ortholog); allergic disease (ortholog); FOUND IN cell surface (ortholog); nucleus (ortholog) | NW_004936539 | 132870 | 145288 | Squirrel | 132 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18676368 | CD274 | CD274 molecule | ENCODES a protein that exhibits receptor ligand activity (inferred); transcription coactivator activity (inferred); INVOLVED IN negative regulation of T cell proliferation (ortholog); positive regulation of cell migration (ortholog); positive regulation of T cell apoptotic process (ortholog); ASSOCI ATED WITH acute myocarditis (ortholog); adult T-cell leukemia/lymphoma (ortholog); allergic disease (ortholog); FOUND IN cell surface (ortholog); nucleus (ortholog) | | | | Green Monkey | 132 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14010360 | CD274 | CD274 molecule | ENCODES a protein that exhibits receptor ligand activity (inferred); transcription coactivator activity (inferred); INVOLVED IN negative regulation of activated T cell proliferation; positive regulation of T cell apoptotic process; negative regulation of T cell proliferation (ortholog); ASSOCIATED W ITH acute myocarditis (ortholog); adult T-cell leukemia/lymphoma (ortholog); allergic disease (ortholog); FOUND IN cell surface (ortholog); nucleus (ortholog) | | | | Pig | 123 | symbol , old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626179861 | cd274 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626174962 | cd274 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18935869 | Cd274 | CD274 molecule | ENCODES a protein that exhibits receptor ligand activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN negative regulation of activated T cell proliferation (ortholog); negative regulation of CD4-positive, alpha-beta T cell proliferation (ortholog); negative regulation of CD 8-positive, alpha-beta T cell activation (ortholog); ASSOCIATED WITH acute myocarditis (ortholog); adult T-cell leukemia/lymphoma (ortholog); allergic disease (ortholog); FOUND IN cell surface (ortholog); extracellular exosome (ortholog); nuclear speck (ortholog) | | | | Naked Mole-Rat | 127 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626064068 | Cd274 | CD274 molecule | ENCODES a protein that exhibits receptor ligand activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); immune response (ortholog); negative regulation of activated T cell proliferation (ortholog); ASSOCIATED WITH acute myoc arditis (ortholog); adult T-cell leukemia/lymphoma (ortholog); allergic disease (ortholog); FOUND IN cell surface (ortholog); early endosome membrane (ortholog); external side of plasma membrane (ortholog) | | | | Black Rat | 120 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
