| 620535 | Cblb | Cbl proto-oncogene B | ENCODES a protein that exhibits protein kinase binding; ubiquitin protein ligase activity (ortholog); INVOLVED IN cellular response to hydrogen peroxide; negative regulation of apoptotic process; response to gravity; PARTICIPATES IN chronic myeloid leukemia pathway; endocytosis pathway; epidermal gr owth factor/neuregulin signaling pathway; ASSOCIATED WITH Experimental Arthritis; Peripheral Nerve Injuries; type 1 diabetes mellitus; FOUND IN cytosol (ortholog); glutamatergic synapse (ortholog); plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 11 | 62058829 | 62225904 | Rat | 232 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 733798 | CBLB | Cbl proto-oncogene B | This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017] | 3 | 105655461 | 105869449 | Human | 269 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 733799 | Cblb | Cbl proto-oncogene b | Predicted to enable receptor tyrosine kinase binding activity and ubiquitin protein ligase activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway; regulation of postsynaptic neurotransmitter receptor internalization; and regulation protein catabolic proce ss at postsynapse. Acts upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of T cell anergy; and positive regulation of protein metabolic process. Is active in glutamatergic synapse and postsynapse. Is expressed in brain; extrinsic ocular muscle; and incisor. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; stomach carcinoma; and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 51851593 | 52028410 | Mouse | 254 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9004883 | Cblb | Cbl proto-oncogene B | ENCODES a protein that exhibits protein kinase binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); immune response (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Experimental Arthritis (ortholog); Experimental Autoimmune Encephalomyelitis (ortholog); infantile onset multisystem autoimmune disease 3 (ortholog); FOUND IN cytosol (ortholog); glutamatergic synapse (ortholog); plasma membrane (ortholog) | NW_004955427 | 6601651 | 6812896 | Chinchilla | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11669544 | CBLB | Cbl proto-oncogene B | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); immune response (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Experimental Arthritis (ortholog); Experimental Autoimmune Encephalomyelitis (or tholog); infantile onset multisystem autoimmune disease 3 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); glutamatergic synapse (inferred) | 3 | 102752406 | 102966414 | Bonobo | 100 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12424011 | CBLB | Cbl proto-oncogene B | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); immune response (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Experimental Arthritis (ortholog); Experimental Autoimmune Encephalomyelitis (or tholog); infantile onset multisystem autoimmune disease 3 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); glutamatergic synapse (inferred) | 33 | 11255453 | 11665755 | Dog | 100 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12542997 | Cblb | Cbl proto-oncogene B | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); immune response (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Experimental Arthritis (ortholog); Experimental Autoimmune Encephalomyelitis (or tholog); infantile onset multisystem autoimmune disease 3 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); glutamatergic synapse (inferred) | NW_004936701 | 1157790 | 1353375 | Squirrel | 100 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257414 | cblb | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18547874 | CBLB | Cbl proto-oncogene B | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); immune response (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Experimental Arthritis (ortholog); Experimental Autoimmune Encephalomyelitis (or tholog); infantile onset multisystem autoimmune disease 3 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); glutamatergic synapse (inferred) | | | | Green Monkey | 100 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626031595 | Cblb | Cbl proto-oncogene B | ENCODES a protein that exhibits protein kinase binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); immune response (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Experimental Arthritis (ortholog); Experimental Autoimmune Encephalomyelitis (ortholog); infantile onset multisystem autoimmune disease 3 (ortholog); FOUND IN cytosol (ortholog); glutamatergic synapse (ortholog); plasma membrane (ortholog) | | | | Black Rat | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18925331 | Cblb | Cbl proto-oncogene B | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); immune response (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Experimental Arthritis (ortholog); Experimental Autoimmune Encephalomyelitis (or tholog); infantile onset multisystem autoimmune disease 3 (ortholog); FOUND IN cytosol (ortholog); glutamatergic synapse (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 100 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13946713 | CBLB | Cbl proto-oncogene B | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); immune response (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH Experimental Arthritis (ortholog); Experimental Autoimmune Encephalomyelitis (or tholog); infantile onset multisystem autoimmune disease 3 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); glutamatergic synapse (inferred) | | | | Pig | 100 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250932 | cblb.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234459 | cblb.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1347796 | MMAB | metabolism of cobalamin associated B | This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complem entation group. Alternatively spliced transcript variants have been found. [provided by RefSeq, Apr 2011] | 12 | 109553715 | 109573504 | Human | 267 | old_gene_name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1610957 | G730013B05Rik | RIKEN cDNA G730013B05 gene | | 16 | 50346608 | 50379822 | Mouse | | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1616682 | Mmab | methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human) | Predicted to enable cobalamin binding activity and corrinoid adenosyltransferase activity. Predicted to be involved in cobalamin metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; lung; nervous system; and trophectoder m. Human ortholog(s) of this gene implicated in inherited metabolic disorder and methylmalonic acidemia cblB type. Orthologous to human MMAB (metabolism of cobalamin associated B). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 114569095 | 114582134 | Mouse | 147 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1596242 | Mmab | metabolism of cobalamin associated B | ENCODES a protein that exhibits cobalamin binding (ortholog); corrinoid adenosyltransferase activity (ortholog); transferase activity, transferring alkyl or aryl (other than methyl) groups (ortholog); INVOLVED IN cobalamin metabolic process (ortholog); ASSOCIATED WITH genetic disease (ortholog); gly cogen storage disease I (ortholog); glycogen storage disease Ia (ortholog); FOUND IN mitochondrion (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A | 12 | 47819757 | 47833127 | Rat | 131 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8788673 | Mmab | metabolism of cobalamin associated B | ENCODES a protein that exhibits cobalamin binding (ortholog); corrinoid adenosyltransferase activity (ortholog); transferase activity, transferring alkyl or aryl (other than methyl) groups (ortholog); INVOLVED IN cobalamin metabolic process (ortholog); ASSOCIATED WITH genetic disease (ortholog); gly cogen storage disease I (ortholog); glycogen storage disease Ia (ortholog); FOUND IN mitochondrion (ortholog) | NW_004955455 | 8954099 | 8985170 | Chinchilla | 18 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12001598 | MMAB | metabolism of cobalamin associated B | ENCODES a protein that exhibits ATP binding (inferred); cobalamin binding (inferred); corrinoid adenosyltransferase activity (inferred); INVOLVED IN cobalamin metabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease I (ortholog); glycogen storage disease Ia (ortholog); FOUND IN mitochondrion (ortholog) | 12 | 107130410 | 107150274 | Bonobo | 24 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12364063 | MMAB | metabolism of cobalamin associated B | ENCODES a protein that exhibits ATP binding (inferred); cobalamin binding (inferred); corrinoid adenosyltransferase activity (inferred); INVOLVED IN cobalamin metabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease I (ortholog); glycogen storage disease Ia (ortholog); FOUND IN mitochondrion (ortholog) | 26 | 17519158 | 17531200 | Dog | 24 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12713299 | Mmab | metabolism of cobalamin associated B | ENCODES a protein that exhibits ATP binding (inferred); cobalamin binding (inferred); corrinoid adenosyltransferase activity (inferred); INVOLVED IN cobalamin metabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease I (ortholog); glycogen storage disease Ia (ortholog); FOUND IN mitochondrion (ortholog) | NW_004936769 | 1261553 | 1274353 | Squirrel | 24 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14125813 | MMAB | metabolism of cobalamin associated B | ENCODES a protein that exhibits ATP binding (inferred); cobalamin binding (inferred); corrinoid adenosyltransferase activity (inferred); INVOLVED IN cobalamin metabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease I (ortholog); glycogen storage disease Ia (ortholog); FOUND IN mitochondrion (ortholog) | | | | Pig | 24 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18928691 | Mmab | metabolism of cobalamin associated B | ENCODES a protein that exhibits cobalamin binding (ortholog); transferase activity, transferring alkyl or aryl (other than methyl) groups (ortholog); INVOLVED IN cobalamin metabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease I (ortholog); glycogen storag e disease Ia (ortholog); FOUND IN mitochondrion (ortholog) | | | | Naked Mole-Rat | 22 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18411323 | MMAB | metabolism of cobalamin associated B | ENCODES a protein that exhibits ATP binding (inferred); cobalamin binding (inferred); corrinoid adenosyltransferase activity (inferred); INVOLVED IN cobalamin metabolic process (inferred); ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease I (ortholog); glycogen storage disease Ia (ortholog); FOUND IN mitochondrion (ortholog) | | | | Green Monkey | 24 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
