| 2246 | Cacna1e | calcium voltage-gated channel subunit alpha1 E | ENCODES a protein that exhibits voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels; voltage-gated monoatomic cation channel activity (ortholog); INVOLVED IN calcium ion import; regulation of synaptic vesicle e xocytosis; behavioral fear response (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; mitogen activated protein kinase signaling pathway; ASSOCIATED WITH increased kindling response; ASSOCIATED WITH Coma (ortholog); developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 69 (ortholog); FOUND IN GABA-ergic synapse; perikaryon; voltage-gated calcium channel complex; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 2,4,6-trinitrobenzenesulfonic acid | 13 | 69125048 | 69613795 | Rat | 175 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 733702 | CACNA1E | calcium voltage-gated channel subunit alpha1 E | Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contra ction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] | 1 | 181317699 | 181808084 | Human | 229 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 733703 | Cacna1e | calcium channel, voltage-dependent, R type, alpha 1E subunit | This gene encodes an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes. Voltage-dependent calcium channels are multi-subunit complexes, comprised of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The isoform alpha-1E gives rise to R-type calcium currents and belongs to the high-voltage activated group. Calcium channels containing the alpha-1E subunit may be involved in the modulation of neuronal firing patterns, an important component of information processing. [provided by RefSeq, Jul 2008] | 1 | 154266552 | 154760374 | Mouse | 207 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8748986 | Cacna1e | calcium voltage-gated channel subunit alpha1 E | ENCODES a protein that exhibits voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); voltage-gated monoatomic cation channel activity (ortholog); INVOLVED IN behavioral fear response (orth olog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Coma (ortholog); developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 69 (ortholog); FOUND IN neuronal cell body; GABA-ergic synapse (ortholog); perikaryon (ortholog) | NW_004955406 | 20356564 | 20824679 | Chinchilla | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11682702 | CACNA1E | calcium voltage-gated channel subunit alpha1 E | ENCODES a protein that exhibits voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN behavioral fear response (ortholog); behavioral response to pain (ortholog); calcium ion im port (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Coma (ortholog); developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 69 (ortholog); FOUND IN GABA-ergic synapse (ortholog); neuronal cell body (ortholog); perikaryon (ortholog) | 1 | 156796855 | 157296987 | Bonobo | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12369026 | CACNA1E | calcium voltage-gated channel subunit alpha1 E | ENCODES a protein that exhibits voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN behavioral fear response (ortholog); behavioral response to pain (ortholog); calcium ion im port (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Coma (ortholog); developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 69 (ortholog); FOUND IN GABA-ergic synapse (ortholog); neuronal cell body (ortholog); perikaryon (ortholog) | 7 | 14892165 | 15267418 | Dog | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12599363 | Cacna1e | calcium voltage-gated channel subunit alpha1 E | ENCODES a protein that exhibits voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN behavioral fear response (ortholog); behavioral response to pain (ortholog); calcium ion im port (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Coma (ortholog); developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 69 (ortholog); FOUND IN GABA-ergic synapse (ortholog); neuronal cell body (ortholog); perikaryon (ortholog) | NW_004936481 | 7694960 | 7908683 | Squirrel | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236958 | cacna1e | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625840458 | Cacna1e | calcium voltage-gated channel subunit alpha1 E | ENCODES a protein that exhibits voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); voltage-gated monoatomic cation channel activity (ortholog); INVOLVED IN behavioral fear response (orth olog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Coma (ortholog); developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 69 (ortholog); FOUND IN GABA-ergic synapse (ortholog); neuronal cell body (ortholog); perikaryon (ortholog) | | | | Black Rat | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908194 | Cacna1e | calcium voltage-gated channel subunit alpha1 E | ENCODES a protein that exhibits voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); voltage-gated monoatomic cation channel activity (ortholog); INVOLVED IN behavioral fear response (orth olog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Coma (ortholog); developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 69 (ortholog); FOUND IN GABA-ergic synapse (ortholog); neuronal cell body (ortholog); perikaryon (ortholog) | | | | Naked Mole-Rat | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13991790 | CACNA1E | calcium voltage-gated channel subunit alpha1 E | ENCODES a protein that exhibits voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN behavioral fear response (ortholog); behavioral response to pain (ortholog); calcium ion im port (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Coma (ortholog); developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 69 (ortholog); FOUND IN GABA-ergic synapse (ortholog); neuronal cell body (ortholog); perikaryon (ortholog); INTERACTS WITH zearalenone | | | | Pig | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18703623 | CACNA1E | calcium voltage-gated channel subunit alpha1 E | ENCODES a protein that exhibits voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN behavioral fear response (ortholog); behavioral response to pain (ortholog); calcium ion im port (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Coma (ortholog); developmental and epileptic encephalopathy (ortholog); developmental and epileptic encephalopathy 69 (ortholog); FOUND IN GABA-ergic synapse (ortholog); neuronal cell body (ortholog); perikaryon (ortholog) | | | | Green Monkey | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237098 | cacna1e.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861339 | cacna1e.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864930 | cacna1e.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626183321 | cacna1e.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626183701 | cacna1e.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863416 | cacna1e.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858705 | cacna1e.S | | | | | | African Clawed Frog | | symbol | gene, null |
