| 620275 | Btc | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding; growth factor activity; receptor ligand activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway; positive regulation of cell differentiation; positive regulation of fibroblast proliferation; PARTICI PATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH otitis media; erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol | 14 | 16992668 | 17031178 | Rat | 138 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733574 | Btc | betacellulin, epidermal growth factor family member | This gene encodes a member of the epidermal growth factor (EGF) family. These growth factors are ligands for the EGFR/ErbB receptor tyrosine kinases, and play roles in cell growth and differentiation. The encoded protein is synthesized as a transmembrane precursor that is proteolytically cleaved to generate a mature peptide, and plays a role in the differentiation of pancreatic beta cells. This gene may also play a protective role in acute pancreatitis, whereas increased expression of this gene may contribute to diabetic macular edema. Gene therapy using combinations of this gene and other pancreas-specific transcription factors may induce islet neogenesis and remediate hyperglycemia in type 1 diabetes. [provided by RefSeq, Apr 2011] | 5 | 91505120 | 91550853 | Mouse | 163 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 736353 | BTC | betacellulin | This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anc hored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015] | 4 | 74744759 | 74794523 | Human | 138 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9059226 | Btc | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); receptor ligand activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB4-ERBB4 signaling pathw ay (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular space (ortholog) | NW_004955474 | 895573 | 946152 | Chinchilla | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11909377 | BTC | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB4-ERBB4 signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPAT ES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | 4 | 49329413 | 49462891 | Bonobo | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12310144 | BTC | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB4-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epider mal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | 15 | 64133051 | 64159155 | Dog | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12478662 | Btc | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB4-ERBB4 signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPAT ES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | NW_004936598 | 971253 | 1019043 | Squirrel | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14022315 | BTC | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB4-ERBB4 signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPAT ES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | | | | Pig | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903782 | Btc | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB2-EGFR signaling pathway (ortholog); ERBB4-ERBB4 signaling pathway (ortholog); PARTICIPATES IN epider mal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18464149 | BTC | betacellulin | ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); growth factor activity (ortholog); INVOLVED IN epidermal growth factor receptor signaling pathway (ortholog); ERBB4-ERBB4 signaling pathway (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPAT ES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH erythropoietic protoporphyria (ortholog); Experimental Diabetes Mellitus (ortholog); Glucagonoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | | | | Green Monkey | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247458 | btc | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155247459 | btc.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155254183 | btc.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1315717 | KIN | Kin17 DNA and RNA binding protein | The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] | 10 | 7750962 | 7787993 | Human | 88 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1348864 | NETO1 | neuropilin and tolloid like 1 | This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor comp lexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017] | 18 | 72742314 | 72867987 | Human | 94 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1558106 | Neto1 | neuropilin (NRP) and tolloid (TLL)-like 1 | Enables ionotropic glutamate receptor binding activity. Involved in learning or memory; modulation of chemical synaptic transmission; and protein localization to synapse. Acts upstream of or within positive regulation of excitatory postsynaptic potential and receptor localization to synapse. Located in excitatory synapse and postsynaptic density. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in central nervous system and retina inner nuclear layer. Orthologous to human NETO1 (neuropilin and tolloid like 1). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 86411110 | 86524482 | Mouse | 105 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1313264 | NETO2 | neuropilin and tolloid like 2 | This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of th is gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] | 16 | 47077703 | 47143945 | Human | 109 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1313265 | Neto2 | neuropilin (NRP) and tolloid (TLL)-like 2 | Enables ionotropic glutamate receptor binding activity. Predicted to be involved in neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Located in postsynaptic density. Is act ive in glutamatergic synapse and postsynaptic density membrane. Is expressed in central nervous system and retina. Orthologous to human NETO2 (neuropilin and tolloid like 2). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 86363347 | 86428011 | Mouse | 116 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732702 | CD9 | CD9 molecule | This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes i ncluding differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011] | 12 | 6199946 | 6238266 | Human | 314 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
