NETO2 (neuropilin and tolloid like 2) - Rat Genome Database

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Gene: NETO2 (neuropilin and tolloid like 2) Homo sapiens
Analyze
Symbol: NETO2
Name: neuropilin and tolloid like 2
RGD ID: 1313264
HGNC Page HGNC
Description: Predicted to enable ionotropic glutamate receptor binding activity. Predicted to be involved in regulation of kainate selective glutamate receptor activity. Predicted to be located in synapse.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2; BTCL2; FLJ10430; FLJ14724; FLJ90456; NEOT2; neuropilin (NRP) and tolloid (TLL)-like 2; neuropilin and tolloid-like protein 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC392268  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1647,077,703 - 47,143,945 (-)EnsemblGRCh38hg38GRCh38
GRCh381647,077,703 - 47,144,025 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371647,111,614 - 47,177,856 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361645,672,943 - 45,735,409 (-)NCBINCBI36hg18NCBI36
Build 341645,672,942 - 45,735,409NCBI
Celera1631,623,547 - 31,686,008 (-)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1633,005,358 - 33,055,863 (-)NCBIHuRef
CHM1_11648,522,400 - 48,584,943 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:11943477   PMID:12477932   PMID:12975309   PMID:14702039   PMID:15340161   PMID:15489334   PMID:16344560   PMID:17671192   PMID:18841201   PMID:19217376   PMID:19322201   PMID:19349369  
PMID:26186194   PMID:26277340   PMID:26496610   PMID:26638075   PMID:26699544   PMID:28514442   PMID:29117863   PMID:29297384   PMID:29395067   PMID:29989576   PMID:30770791   PMID:30975469  
PMID:32788342   PMID:33157203   PMID:33263384   PMID:33845483   PMID:34079125  


Genomics

Comparative Map Data
NETO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1647,077,703 - 47,143,945 (-)EnsemblGRCh38hg38GRCh38
GRCh381647,077,703 - 47,144,025 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371647,111,614 - 47,177,856 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361645,672,943 - 45,735,409 (-)NCBINCBI36hg18NCBI36
Build 341645,672,942 - 45,735,409NCBI
Celera1631,623,547 - 31,686,008 (-)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1633,005,358 - 33,055,863 (-)NCBIHuRef
CHM1_11648,522,400 - 48,584,943 (-)NCBICHM1_1
Neto2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39886,363,347 - 86,428,011 (-)NCBIGRCm39mm39
GRCm39 Ensembl886,363,217 - 86,427,553 (-)Ensembl
GRCm38885,636,718 - 85,700,952 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl885,636,588 - 85,700,924 (-)EnsemblGRCm38mm10GRCm38
MGSCv37888,160,487 - 88,214,908 (-)NCBIGRCm37mm9NCBIm37
MGSCv36888,526,693 - 88,591,029 (-)NCBImm8
Celera889,933,071 - 89,987,458 (-)NCBICelera
Cytogenetic Map8C3NCBI
Neto2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21921,344,299 - 21,418,182 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1921,344,289 - 21,417,023 (+)Ensembl
Rnor_6.01922,450,579 - 22,486,530 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1922,450,030 - 22,486,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01933,457,454 - 33,493,499 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41922,730,832 - 22,767,097 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11922,735,659 - 22,771,923 (+)NCBI
Celera1921,245,766 - 21,277,753 (+)NCBICelera
Cytogenetic Map19p11NCBI
Neto2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554748,035,874 - 8,106,397 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554748,035,874 - 8,106,397 (+)NCBIChiLan1.0ChiLan1.0
NETO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11646,235,159 - 46,284,345 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1646,235,165 - 46,284,344 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01627,343,333 - 27,405,173 (-)NCBIMhudiblu_PPA_v0panPan3
NETO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1267,781,264 - 67,835,859 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl267,789,035 - 67,835,436 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha264,352,618 - 64,410,923 (+)NCBI
ROS_Cfam_1.0268,335,394 - 68,393,785 (+)NCBI
UMICH_Zoey_3.1265,147,926 - 65,206,011 (+)NCBI
UNSW_CanFamBas_1.0266,171,747 - 66,229,387 (+)NCBI
UU_Cfam_GSD_1.0267,162,848 - 67,221,041 (+)NCBI
Neto2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934959,080,718 - 59,139,896 (+)NCBI
SpeTri2.0NW_004936475450,382 - 508,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NETO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl637,443,384 - 37,505,737 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1637,443,534 - 37,506,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2632,686,485 - 32,749,506 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NETO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1532,929,091 - 32,991,240 (-)NCBI
ChlSab1.1 Ensembl532,930,692 - 32,979,561 (-)Ensembl
Vero_WHO_p1.0NW_02366604743,575,499 - 43,639,197 (+)NCBI
Neto2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624914636,348 - 690,708 (-)NCBI

Position Markers
NIB1885  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371647,116,796 - 47,116,895UniSTSGRCh37
Build 361645,674,297 - 45,674,396RGDNCBI36
Celera1631,624,901 - 31,625,000RGD
Cytogenetic Map16q11UniSTS
HuRef1633,006,723 - 33,006,822UniSTS
Whitehead-YAC Contig Map16 UniSTS
RH67124  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371647,149,961 - 47,150,061UniSTSGRCh37
Build 361645,707,462 - 45,707,562RGDNCBI36
Celera1631,658,066 - 31,658,166RGD
Cytogenetic Map16q11UniSTS
HuRef1633,039,888 - 33,039,988UniSTS
RH48278  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371647,154,858 - 47,154,988UniSTSGRCh37
Build 361645,712,359 - 45,712,489RGDNCBI36
Celera1631,662,963 - 31,663,093RGD
Cytogenetic Map16q11UniSTS
HuRef1633,044,785 - 33,044,915UniSTS
HSCZTF122  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371647,115,729 - 47,115,929UniSTSGRCh37
Build 361645,673,230 - 45,673,430RGDNCBI36
Celera1631,623,834 - 31,624,034RGD
Cytogenetic Map16q11UniSTS
HuRef1633,005,656 - 33,005,856UniSTS
Whitehead-RH Map16234.7UniSTS
G32435  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371647,149,961 - 47,150,061UniSTSGRCh37
Celera1631,658,066 - 31,658,166UniSTS
Cytogenetic Map16q11UniSTS
HuRef1633,039,888 - 33,039,988UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3117
Count of miRNA genes:1073
Interacting mature miRNAs:1319
Transcripts:ENST00000303155, ENST00000562435, ENST00000562559, ENST00000563078, ENST00000564667
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 118 4 38 10 544 13 169 43 673 143 174 277 8
Low 1192 1445 1261 270 1176 128 1969 765 2684 233 1042 1325 148 1 683 1150 4 1
Below cutoff 1129 1540 420 337 231 317 2219 1389 377 43 244 11 19 521 1638 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_047201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001201477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_018092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006721289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006721291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006721292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK001292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL834404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX164139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC108727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX538063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ783994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA117339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000303155   ⟹   ENSP00000306726
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1647,081,634 - 47,143,709 (-)Ensembl
RefSeq Acc Id: ENST00000562435   ⟹   ENSP00000455169
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1647,077,703 - 47,143,945 (-)Ensembl
RefSeq Acc Id: ENST00000562559   ⟹   ENSP00000454213
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1647,082,990 - 47,128,458 (-)Ensembl
RefSeq Acc Id: ENST00000563078   ⟹   ENSP00000456818
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1647,083,614 - 47,122,903 (-)Ensembl
RefSeq Acc Id: ENST00000564667   ⟹   ENSP00000457133
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1647,083,107 - 47,109,634 (-)Ensembl
RefSeq Acc Id: NM_001201477   ⟹   NP_001188406
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381647,077,703 - 47,143,945 (-)NCBI
GRCh371647,115,431 - 47,177,936 (-)ENTREZGENE
HuRef1633,005,358 - 33,055,863 (-)ENTREZGENE
CHM1_11648,522,400 - 48,584,943 (-)NCBI
Sequence:
RefSeq Acc Id: NM_018092   ⟹   NP_060562
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381647,077,703 - 47,143,945 (-)NCBI
GRCh371647,115,431 - 47,177,936 (-)ENTREZGENE
Build 361645,672,943 - 45,735,409 (-)NCBI Archive
Celera1631,623,547 - 31,686,008 (-)RGD
HuRef1633,005,358 - 33,055,863 (-)ENTREZGENE
CHM1_11648,522,400 - 48,584,943 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006721289   ⟹   XP_006721352
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381647,081,637 - 47,144,025 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006721291   ⟹   XP_006721354
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381647,081,637 - 47,144,025 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006721292   ⟹   XP_006721355
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381647,100,948 - 47,144,025 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017023740   ⟹   XP_016879229
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381647,081,637 - 47,134,230 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_060562   ⟸   NM_018092
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8NC67 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001188406   ⟸   NM_001201477
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8NC67 (UniProtKB/Swiss-Prot),   Q32NC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006721354   ⟸   XM_006721291
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006721352   ⟸   XM_006721289
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006721355   ⟸   XM_006721292
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016879229   ⟸   XM_017023740
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000454213   ⟸   ENST00000562559
RefSeq Acc Id: ENSP00000455169   ⟸   ENST00000562435
RefSeq Acc Id: ENSP00000456818   ⟸   ENST00000563078
RefSeq Acc Id: ENSP00000457133   ⟸   ENST00000564667
RefSeq Acc Id: ENSP00000306726   ⟸   ENST00000303155
Protein Domains
CUB   LDL-receptor class A

Promoters
RGD ID:6793312
Promoter ID:HG_KWN:23730
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_018092,   UC002EES.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361645,735,206 - 45,735,706 (-)MPROMDB
RGD ID:7232145
Promoter ID:EPDNEW_H21818
Type:initiation region
Name:NETO2_1
Description:neuropilin and tolloid like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381647,143,945 - 47,144,005EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q11.2-12.1(chr16:46466829-52314178)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052404]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052404]|See cases [RCV000052404] Chr16:46466829..52314178 [GRCh38]
Chr16:46500741..52348090 [GRCh37]
Chr16:45058242..50905591 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46466829-51939304)x1 copy number loss See cases [RCV000053309] Chr16:46466829..51939304 [GRCh38]
Chr16:46500741..51973216 [GRCh37]
Chr16:45058242..50530717 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46466829-51673196)x1 copy number loss See cases [RCV000053310] Chr16:46466829..51673196 [GRCh38]
Chr16:46500741..51707107 [GRCh37]
Chr16:45058242..50264608 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46471520-52405956)x1 copy number loss See cases [RCV000053328] Chr16:46471520..52405956 [GRCh38]
Chr16:46505432..52439868 [GRCh37]
Chr16:45062933..50997369 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
NM_018092.5(NETO2):c.1532G>C (p.Arg511Thr) single nucleotide variant Malignant tumor of prostate [RCV000149248] Chr16:47083267 [GRCh38]
Chr16:47117178 [GRCh37]
Chr16:16q12.1
uncertain significance
GRCh38/hg38 16q11.2-12.1(chr16:46466829-52422170)x1 copy number loss See cases [RCV000137306] Chr16:46466829..52422170 [GRCh38]
Chr16:46500741..52456082 [GRCh37]
Chr16:45058242..51013583 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh38/hg38 16q11.2-12.1(chr16:46466829-52355793)x3 copy number gain See cases [RCV000137170] Chr16:46466829..52355793 [GRCh38]
Chr16:46500741..52389705 [GRCh37]
Chr16:45058242..50947206 [NCBI36]
Chr16:16q11.2-12.1
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Ductal breast carcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3
uncertain significance
GRCh37/hg19 16q11.2-12.1(chr16:46615804-47345238)x1 copy number loss Ductal breast carcinoma [RCV000207035] Chr16:46615804..47345238 [GRCh37]
Chr16:16q11.2-12.1
uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p11.2-q21(chr16:34197492-64509054)x3 copy number gain See cases [RCV000511791] Chr16:34197492..64509054 [GRCh37]
Chr16:16p11.2-q21
pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
GRCh37/hg19 16q11.2-12.1(chr16:46737110-51838691)x1 copy number loss See cases [RCV000511950] Chr16:46737110..51838691 [GRCh37]
Chr16:16q11.2-12.1
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
Single allele duplication not provided [RCV001542388] Chr16:46385317..61223349 [GRCh38]
Chr16:16q11.2-21
pathogenic
GRCh37/hg19 16q12.1(chr16:47116679-47424828)x1 copy number loss not provided [RCV000751667] Chr16:47116679..47424828 [GRCh37]
Chr16:16q12.1
benign
GRCh37/hg19 16q12.1(chr16:47177234-47177650)x1 copy number loss not provided [RCV000751668] Chr16:47177234..47177650 [GRCh37]
Chr16:16q12.1
benign
GRCh37/hg19 16q12.1(chr16:47177234-47178066)x1 copy number loss not provided [RCV000751669] Chr16:47177234..47178066 [GRCh37]
Chr16:16q12.1
benign
GRCh37/hg19 16q12.1(chr16:47177234-47194051)x3 copy number gain not provided [RCV000751670] Chr16:47177234..47194051 [GRCh37]
Chr16:16q12.1
benign
GRCh37/hg19 16q12.1(chr16:47177234-47224693)x1 copy number loss not provided [RCV000751671] Chr16:47177234..47224693 [GRCh37]
Chr16:16q12.1
benign
GRCh37/hg19 16q12.1(chr16:47177300-47178066)x1 copy number loss not provided [RCV000751672] Chr16:47177300..47178066 [GRCh37]
Chr16:16q12.1
benign
GRCh37/hg19 16q12.1(chr16:47177300-47194051)x4 copy number gain not provided [RCV000751673] Chr16:47177300..47194051 [GRCh37]
Chr16:16q12.1
benign
NM_018092.5(NETO2):c.1366T>A (p.Ser456Thr) single nucleotide variant not provided [RCV000947700] Chr16:47083433 [GRCh38]
Chr16:47117344 [GRCh37]
Chr16:16q12.1
benign
GRCh37/hg19 16q11.2-12.1(chr16:46503968-47312075)x3 copy number gain not provided [RCV001259853] Chr16:46503968..47312075 [GRCh37]
Chr16:16q11.2-12.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14644 AgrOrtholog
COSMIC NETO2 COSMIC
Ensembl Genes ENSG00000171208 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000306726 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000454213 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000455169 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000456818 UniProtKB/TrEMBL
  ENSP00000457133 UniProtKB/TrEMBL
Ensembl Transcript ENST00000303155 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000562435 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000562559 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000563078 UniProtKB/TrEMBL
  ENST00000564667 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000171208 GTEx
HGNC ID HGNC:14644 ENTREZGENE
Human Proteome Map NETO2 Human Proteome Map
InterPro CUB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NETO2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:81831 UniProtKB/Swiss-Prot
NCBI Gene 81831 ENTREZGENE
OMIM 607974 OMIM
PANTHER PTHR45645:SF22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31559 PharmGKB
PROSITE CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H3BM37_HUMAN UniProtKB/TrEMBL
  H3BSR0_HUMAN UniProtKB/TrEMBL
  H3BTE1_HUMAN UniProtKB/TrEMBL
  NETO2_HUMAN UniProtKB/Swiss-Prot
  Q32NC3 ENTREZGENE, UniProtKB/TrEMBL
  Q8NC67 ENTREZGENE
UniProt Secondary J3KNF1 UniProtKB/Swiss-Prot
  Q7Z381 UniProtKB/Swiss-Prot
  Q8ND51 UniProtKB/Swiss-Prot
  Q96SP4 UniProtKB/Swiss-Prot
  Q9NVY8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-08 NETO2  neuropilin and tolloid like 2    neuropilin (NRP) and tolloid (TLL)-like 2  Symbol and/or name change 5135510 APPROVED