| 1345228 | BRSK2 | BR serine/threonine kinase 2 | Enables several functions, including ATP binding activity; ATPase binding activity; and magnesium ion binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 1389934 | 1462689 | Human | 135 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1566256 | Brsk2 | BR serine/threonine kinase 2 | ENCODES a protein that exhibits protein serine/threonine kinase activity; ATP binding (ortholog); ATPase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); axonogenesis (ortholog); DNA damage response (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 11 (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN distal axon; centrosome (ortholog); cytoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A | 1 | 206465040 | 206518156 | Rat | 149 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1621464 | Brsk2 | BR serine/threonine kinase 2 | Enables protein kinase binding activity and tau-protein kinase activity. Involved in several processes, including microtubule cytoskeleton organization involved in establishment of planar polarity; regulation of axonogenesis; and regulation of insulin secretion involved in cellular response to gluco se stimulus. Acts upstream of or within central nervous system neuron differentiation; neuron projection morphogenesis; and peptidyl-serine phosphorylation. Predicted to be located in distal axon and endoplasmic reticulum. Predicted to be active in centrosome. Is expressed in several structures, including central nervous system and retina. Orthologous to human BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 141503488 | 141557981 | Mouse | 149 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8880268 | Brsk2 | BR serine/threonine kinase 2 | ENCODES a protein that exhibits ATP binding (ortholog); ATPase binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); axonogenesis (ortholog); ERAD pathway (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 11 (ortholog); gen etic disease (ortholog); intellectual disability (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); distal axon (ortholog) | NW_004955476 | 10911515 | 10951544 | Chinchilla | 40 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11702008 | BRSK2 | BR serine/threonine kinase 2 | ENCODES a protein that exhibits ATP binding (inferred); ATPase binding (inferred); kinase activity (inferred); INVOLVED IN establishment of cell polarity (ortholog); neuron differentiation (ortholog); neuron projection morphogenesis (ortholog); ASSOCIATED WITH developmental and epileptic encephalopa thy 11 (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN distal axon (ortholog) | 11 | 1424873 | 1495630 | Bonobo | 50 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12310683 | BRSK2 | BR serine/threonine kinase 2 | ENCODES a protein that exhibits ATP binding (inferred); ATPase binding (inferred); kinase activity (inferred); INVOLVED IN establishment of cell polarity (ortholog); neuron differentiation (ortholog); neuron projection morphogenesis (ortholog); ASSOCIATED WITH developmental and epileptic encephalopa thy 11 (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN distal axon (ortholog) | 18 | 45666489 | 45688950 | Dog | 54 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12515734 | Brsk2 | BR serine/threonine kinase 2 | ENCODES a protein that exhibits ATP binding (inferred); ATPase binding (inferred); kinase activity (inferred); INVOLVED IN establishment of cell polarity (ortholog); neuron differentiation (ortholog); neuron projection morphogenesis (ortholog); ASSOCIATED WITH developmental and epileptic encephalopa thy 11 (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN distal axon (ortholog) | NW_004936816 | 307736 | 335953 | Squirrel | 51 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155249272 | brsk2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18791703 | BRSK2 | BR serine/threonine kinase 2 | ENCODES a protein that exhibits ATP binding (inferred); ATPase binding (inferred); kinase activity (inferred); INVOLVED IN establishment of cell polarity (ortholog); neuron differentiation (ortholog); neuron projection morphogenesis (ortholog); ASSOCIATED WITH developmental and epileptic encephalopa thy 11 (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN distal axon (ortholog) | | | | Green Monkey | 55 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18923848 | Brsk2 | BR serine/threonine kinase 2 | ENCODES a protein that exhibits ATPase binding (ortholog); magnesium ion binding (ortholog); protein kinase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); axonogenesis (ortholog); ERAD pathway (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 11 (ort holog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN distal axon (ortholog); endoplasmic reticulum (ortholog) | | | | Naked Mole-Rat | 50 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625933408 | Brsk2 | BR serine/threonine kinase 2 | ENCODES a protein that exhibits ATP binding (ortholog); ATPase binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); axonogenesis (ortholog); ERAD pathway (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 11 (ortholog); gen etic disease (ortholog); intellectual disability (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); distal axon (ortholog) | | | | Black Rat | 40 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14222938 | BRSK2 | BR serine/threonine kinase 2 | ENCODES a protein that exhibits ATP binding (inferred); ATPase binding (inferred); kinase activity (inferred); INVOLVED IN establishment of cell polarity (ortholog); neuron differentiation (ortholog); neuron projection morphogenesis (ortholog); ASSOCIATED WITH developmental and epileptic encephalopa thy 11 (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN distal axon (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 55 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626182318 | brsk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864281 | brsk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626174725 | brsk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862485 | brsk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863851 | brsk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862210 | brsk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858785 | brsk2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468115 | brsk2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858583 | brsk2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859609 | brsk2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862280 | brsk2.S | | | | | | African Clawed Frog | | symbol | gene, null |
