Brsk2 (BR serine/threonine kinase 2) - Rat Genome Database

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Gene: Brsk2 (BR serine/threonine kinase 2) Ictidomys tridecemlineatus
Analyze
Symbol: Brsk2
Name: BR serine/threonine kinase 2
RGD ID: 12515734
Description: ENCODES a protein that exhibits ATP binding (inferred); ATPase binding (inferred); kinase activity (inferred); INVOLVED IN establishment of cell polarity (ortholog); neuron differentiation (ortholog); neuron projection morphogenesis (ortholog); ASSOCIATED WITH delta beta-thalassemia (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN distal axon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BR serine/threonine kinase 2, transcript variant X1; BR serine/threonine kinase 2, transcript variant X2; BR serine/threonine kinase 2, transcript variant X3; BR serine/threonine kinase 2, transcript variant X4; serine/threonine-protein kinase BRSK2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936816307,250 - 334,785 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936816307,736 - 335,953 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Brsk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936816307,250 - 334,785 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936816307,736 - 335,953 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRSK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,389,934 - 1,462,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,389,899 - 1,462,689 (+)EnsemblGRCh38hg38GRCh38
GRCh37111,411,164 - 1,483,919 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,367,705 - 1,439,908 (+)NCBINCBI36Build 36hg18NCBI36
Build 34111,367,704 - 1,439,902NCBI
Celera111,444,570 - 1,515,142 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,221,716 - 1,271,938 (+)NCBIHuRef
CHM1_1111,410,344 - 1,482,831 (+)NCBICHM1_1
T2T-CHM13v2.0111,461,201 - 1,537,121 (+)NCBIT2T-CHM13v2.0
Brsk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,503,488 - 141,557,981 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,503,488 - 141,557,984 (+)EnsemblGRCm39 Ensembl
GRCm387141,949,751 - 142,004,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,949,751 - 142,004,247 (+)EnsemblGRCm38mm10GRCm38
MGSCv377149,135,656 - 149,190,149 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,759,141 - 141,813,634 (+)NCBIMGSCv36mm8
Celera7141,703,446 - 141,758,649 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.43NCBI
Brsk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,465,040 - 206,518,156 (+)NCBIGRCr8
mRatBN7.21197,035,505 - 197,088,624 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,035,633 - 197,088,092 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01214,918,757 - 214,940,883 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,927,172 - 214,947,624 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,828,575 - 221,862,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,083,095 - 202,133,268 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1194,692,139 - 194,712,878 (+)NCBICelera
Cytogenetic Map1q41NCBI
Brsk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547610,911,515 - 10,929,183 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547610,911,515 - 10,951,544 (-)NCBIChiLan1.0ChiLan1.0
BRSK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,807,992 - 3,878,526 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,020,624 - 3,089,422 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0111,424,873 - 1,495,630 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,473,129 - 1,521,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,473,129 - 1,521,339 (+)Ensemblpanpan1.1panPan2
BRSK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,666,489 - 45,688,950 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,628,970 - 45,689,494 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,240,212 - 44,299,980 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01846,310,123 - 46,369,953 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1846,309,789 - 46,369,799 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,758,085 - 45,817,901 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,339,202 - 45,398,979 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,084,435 - 46,144,294 (+)NCBIUU_Cfam_GSD_1.0
BRSK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2896,585 - 953,108 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12896,720 - 953,908 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103235498
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,193,740 - 1,258,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,193,808 - 1,258,433 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236667626,642 - 32,661 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brsk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,296,120 - 21,334,040 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,296,115 - 21,334,054 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021720528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021720529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021720530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021720531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040283918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040283919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040283921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040283922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040283923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040283924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040283925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040283926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040283927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040283928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005733382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005733383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005733384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005733385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005733386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000024772   ⟹   ENSSTOP00000016437
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936816307,250 - 334,542 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000030335   ⟹   ENSSTOP00000027392
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936816307,715 - 334,785 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000035648   ⟹   ENSSTOP00000024989
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936816307,715 - 331,120 (+)Ensembl
RefSeq Acc Id: XM_040283918   ⟹   XP_040139852
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBI
RefSeq Acc Id: XM_040283919   ⟹   XP_040139853
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBI
RefSeq Acc Id: XM_040283921   ⟹   XP_040139855
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBI
RefSeq Acc Id: XM_040283922   ⟹   XP_040139856
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBI
RefSeq Acc Id: XM_040283923   ⟹   XP_040139857
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBI
RefSeq Acc Id: XM_040283924   ⟹   XP_040139858
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,080,484 (+)NCBI
RefSeq Acc Id: XM_040283925   ⟹   XP_040139859
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,080,418 (+)NCBI
RefSeq Acc Id: XM_040283926   ⟹   XP_040139860
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBI
RefSeq Acc Id: XM_040283927   ⟹   XP_040139861
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBI
RefSeq Acc Id: XM_040283928   ⟹   XP_040139862
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBI
RefSeq Acc Id: XR_005733382
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBI
RefSeq Acc Id: XR_005733383
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,080,452 (+)NCBI
RefSeq Acc Id: XR_005733384
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,080,328 (+)NCBI
RefSeq Acc Id: XR_005733385
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBI
RefSeq Acc Id: XR_005733386
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244049471,053,652 - 1,081,939 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_040139855   ⟸   XM_040283921
- Peptide Label: isoform X3
- UniProtKB: I3MWE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139857   ⟸   XM_040283923
- Peptide Label: isoform X5
- UniProtKB: A0A287CUN7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139853   ⟸   XM_040283919
- Peptide Label: isoform X2
- UniProtKB: I3MWE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139860   ⟸   XM_040283926
- Peptide Label: isoform X6
- UniProtKB: A0A287D1J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139861   ⟸   XM_040283927
- Peptide Label: isoform X7
- UniProtKB: A0A287D1J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139852   ⟸   XM_040283918
- Peptide Label: isoform X1
- UniProtKB: I3MWE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139856   ⟸   XM_040283922
- Peptide Label: isoform X4
- UniProtKB: I3MWE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139862   ⟸   XM_040283928
- Peptide Label: isoform X8
- UniProtKB: A0A287D1J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139858   ⟸   XM_040283924
- Peptide Label: isoform X5
- UniProtKB: A0A287CUN7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139859   ⟸   XM_040283925
- Peptide Label: isoform X5
- UniProtKB: A0A287CUN7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000024989   ⟸   ENSSTOT00000035648
RefSeq Acc Id: ENSSTOP00000027392   ⟸   ENSSTOT00000030335
RefSeq Acc Id: ENSSTOP00000016437   ⟸   ENSSTOT00000024772
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000021882 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000024772.2 UniProtKB/TrEMBL
  ENSSTOT00000030335.1 UniProtKB/TrEMBL
  ENSSTOT00000035648.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro BRSK1_2-like_UBA UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Brsk2 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE BRSK2-LIKE ISOFORM X1 UniProtKB/TrEMBL
Pfam KA1_BRSK UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  UBA_BRSK UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287CUN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D1J4 ENTREZGENE, UniProtKB/TrEMBL
  I3MWE2 ENTREZGENE, UniProtKB/TrEMBL