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Gene: Brsk2 (BR serine/threonine kinase 2) Rattus norvegicus

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Symbol:

Brsk2

Name:

BR serine/threonine kinase 2

RGD ID:

1566256

Description:

Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; cytoskeleton organization; and intracellular signal transduction. Predicted to act upstream of or within central nervous system neuron differentiation; neuron projection morphogenesis; and peptidyl-serine phosphorylation. Located in distal axon. Orthologous to human BRSK2 (BR serine/threonine kinase 2); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

BR serine/threonine-protein kinase 2; brain serine/threonine kinase 2; brain-specific serine/threonine-protein kinase 2; LOC103691267; serine/threonine-protein kinase BRSK2; serine/threonine-protein kinase BRSK2-like; serine/threonine-protein kinase SAD-A; uncharacterized LOC103691267

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BRSK2 (BR serine/threonine kinase 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Brsk2 (BR serine/threonine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Brsk2 (BR serine/threonine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BRSK2 (BR serine/threonine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BRSK2 (BR serine/threonine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Brsk2 (BR serine/threonine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BRSK2 (BR serine/threonine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BRSK2 (BR serine/threonine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Brsk2 (BR serine/threonine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TBC1D16 (TBC1 domain family member 16)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	BRSK2 (BR serine/threonine kinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Brsk2 (BR serine/threonine kinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	brsk2a (BR serine/threonine kinase 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	brsk2b (BR serine/threonine kinase 2b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	GIN4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	KCC4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	sad-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	sff	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HSL1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	brsk2	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	206,465,040 - 206,518,156 (+)	NCBI		GRCr8
GRCr8 Ensembl	1	206,465,040 - 206,518,156 (+)	Ensembl		GRCr8 Ensembl
mRatBN7.2	1	197,035,505 - 197,088,624 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	197,035,633 - 197,088,092 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	1	214,918,757 - 214,940,883 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	214,927,172 - 214,947,624 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	221,828,575 - 221,862,789 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	202,083,095 - 202,133,268 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	194,692,139 - 194,712,878 (+)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Beckwith-Wiedemann syndrome (ISO)

delta beta-thalassemia (ISO)

developmental and epileptic encephalopathy (ISO)

developmental and epileptic encephalopathy 11 (ISO)

early infantile epileptic encephalopathy (ISO)

genetic disease (ISO)

immunodeficiency 39 (ISO)

intellectual disability (ISO)

Neurodevelopmental Disorders (ISO)

neuronal ceroid lipofuscinosis (ISO)

Segawa Syndrome, Autosomal Recessive (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

coumarin (ISO)

dibutyl phthalate (EXP)

ethanol (ISO)

folic acid (ISO)

L-methionine (ISO)

maneb (ISO)

methapyrilene (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monosodium L-glutamate (ISO)

paracetamol (ISO)

paraquat (ISO)

pirinixic acid (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

sunitinib (ISO)

titanium dioxide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA,ISO)

apoptotic process (IEA)

axonogenesis (IBA,IEA,ISO,ISS)

cell division (IEA)

central nervous system neuron differentiation (IEA,ISO)

DNA damage response (ISS)

ERAD pathway (IEA,ISO)

establishment of cell polarity (IBA,IEA,ISO,ISS)

exocytosis (IEA)

G2/M transition of mitotic cell cycle (IBA,IEA,ISO)

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (IEA,ISO)

microtubule cytoskeleton organization involved in establishment of planar polarity (IEA,ISO)

mitotic G2 DNA damage checkpoint signaling (ISS)

nervous system development (IEA)

neuron differentiation (IEA,ISO)

neuron projection morphogenesis (IEA,ISO)

peptidyl-serine phosphorylation (ISO)

protein phosphorylation (ISO,ISS)

regulation of axonogenesis (IEA,ISO)

regulation of insulin secretion involved in cellular response to glucose stimulus (IEA,ISO)

regulation of neuron projection development (IEA,ISO)

response to ionizing radiation (ISS)

response to UV (ISS)

Cellular Component

centrosome (IBA,IEA,ISO)

cytoplasm (IEA,ISO,ISS)

cytoskeleton (IEA)

distal axon (IMP)

endoplasmic reticulum (IEA,ISO)

nucleus (ISS)

perinuclear region of cytoplasm (IEA)

Molecular Function

ATP binding (IEA,ISO)

ATPase binding (IEA,ISO)

kinase activity (IEA)

magnesium ion binding (IEA,ISO)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein kinase binding (IEA,ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IEA,IMP,ISO,ISS)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.	Lu R, etal., J Biol Chem. 2004 Jul 23;279(30):31164-70. Epub 2004 May 18.
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Polarized activities of AMPK and BRSK in primary hippocampal neurons.	Sample V, etal., Mol Biol Cell. 2015 May 15;26(10):1935-46. doi: 10.1091/mbc.E14-02-0764. Epub 2015 Mar 18.

Additional References at PubMed

PMID:14976552	PMID:15705853	PMID:17482548	PMID:18268107	PMID:20026642	PMID:21985311	PMID:22669945	PMID:22713462	PMID:22798068	PMID:23029325	PMID:23907667	PMID:26514267
PMID:29873699

Genomics

Comparative Map Data

Brsk2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	206,465,040 - 206,518,156 (+)	NCBI		GRCr8
GRCr8 Ensembl	1	206,465,040 - 206,518,156 (+)	Ensembl		GRCr8 Ensembl
mRatBN7.2	1	197,035,505 - 197,088,624 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	197,035,633 - 197,088,092 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	1	214,918,757 - 214,940,883 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	214,927,172 - 214,947,624 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	221,828,575 - 221,862,789 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	202,083,095 - 202,133,268 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	194,692,139 - 194,712,878 (+)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

BRSK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	1,389,934 - 1,462,689 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	1,389,899 - 1,462,689 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	1,411,164 - 1,483,919 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	1,367,705 - 1,439,908 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	1,367,704 - 1,439,902	NCBI
Celera	11	1,444,570 - 1,515,142 (+)	NCBI		Celera
Cytogenetic Map	11	p15.5	NCBI
HuRef	11	1,221,716 - 1,271,938 (+)	NCBI		HuRef
CHM1_1	11	1,410,344 - 1,482,831 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	1,461,201 - 1,537,121 (+)	NCBI		T2T-CHM13v2.0

Brsk2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	141,503,488 - 141,557,981 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	141,503,488 - 141,557,984 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	141,949,751 - 142,004,244 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	141,949,751 - 142,004,247 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	149,135,656 - 149,190,149 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	141,759,141 - 141,813,634 (+)	NCBI		MGSCv36	mm8
Celera	7	141,703,446 - 141,758,649 (+)	NCBI		Celera
Cytogenetic Map	7	F5	NCBI
cM Map	7	87.43	NCBI

Brsk2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955476	10,911,515 - 10,929,183 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955476	10,911,515 - 10,951,544 (-)	NCBI	ChiLan1.0	ChiLan1.0

BRSK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	3,807,992 - 3,878,526 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	3,020,624 - 3,089,422 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	1,424,873 - 1,495,630 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	1,473,129 - 1,521,339 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	1,473,129 - 1,521,339 (+)	Ensembl	panpan1.1		panPan2

BRSK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	45,666,489 - 45,688,950 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	45,628,970 - 45,689,494 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	44,240,212 - 44,299,980 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	46,310,123 - 46,369,953 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	46,309,789 - 46,369,799 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	45,758,085 - 45,817,901 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	45,339,202 - 45,398,979 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	46,084,435 - 46,144,294 (+)	NCBI		UU_Cfam_GSD_1.0

Brsk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	1,053,652 - 1,081,939 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936816	307,250 - 334,785 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936816	307,736 - 335,953 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BRSK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	896,585 - 953,108 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	896,720 - 953,908 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

BRSK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	1,193,740 - 1,258,829 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	1,193,808 - 1,258,433 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666762	6,642 - 32,661 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Brsk2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	21,296,120 - 21,334,040 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624766	21,296,115 - 21,334,054 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Brsk2
388 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	134
Count of miRNA genes:	74
Interacting mature miRNAs:	78
Transcripts:	ENSRNOT00000027134, ENSRNOT00000054868
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	177339686	222339686	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	181059071	226059071	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	181059071	226059071	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	182039247	227039247	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	183564652	228564652	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	193964073	238964073	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	160573753	210707719	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	181059071	226059071	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	139442053	223964440	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	160573753	210707719	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	165278545	210278545	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	181059071	226059071	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	99645382	221502378	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	181059071	226059071	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	194575422	239575422	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	168063662	213063662	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	193400541	238400541	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	159894717	207261263	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	163992710	208992710	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	200449456	256003563	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	182535316	227535316	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	146080545	243492863	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	103779152	223964440	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	98879955	208479939	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	181059071	226059071	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	153679879	232414077	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	160574007	235238518	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	181059071	226059071	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	181059071	226059071	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	202543537	247543537	Rat
1359018	Hrtrt20	Heart rate QTL 20	3.08		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	194786607	207590403	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	162753891	207753891	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	205674651	250674651	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	203300512	229359342	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	180739993	225739993	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	191190115	223964326	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	172718770	228180370	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	186298393	231298393	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	111949780	210707719	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631260	Tcas2	Tongue tumor susceptibility QTL 2	4.93		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	201915593	208479939	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	178547286	206690557	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	188241285	250779312	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	139442053	223964440	Rat
1300168	Bp170	Blood pressure QTL 170	2.76		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	192995199	237995199	Rat
61403	Niddm4	Non-insulin dependent diabetes mellitus QTL 4			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	201464383	246464383	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	186298393	231298393	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	186298393	231298393	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	203675682	248675682	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	111949780	210707719	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	205674651	250674651	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	185979875	230979875	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	197807365	233480676	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	210707719	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	193400541	238400541	Rat
634338	Hcar4	Hepatocarcinoma resistance QTL 4	4.6		liver integrity trait (VT:0010547)	liver tumorous lesion number to liver area ratio (CMO:0001210)	1	202851915	223964440	Rat
6480783	Insul19	Insulin level QTL 19	4.33		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	203300512	213659238	Rat
1354618	Kidm15	Kidney mass QTL 15	5		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	1	165707719	210707719	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	173363824	227535316	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	191260175	236260175	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	111949780	228180370	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2325727	Pia41	Pristane induced arthritis QTL 41			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	188241285	233241285	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	210707719	Rat

Markers in Region

RH142958

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	197,087,801 - 197,087,942 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	214,948,822 - 214,948,962	NCBI	Rnor6.0
Rnor_5.0	1	221,861,968 - 221,862,108	UniSTS	Rnor5.0
RGSC_v3.4	1	202,133,412 - 202,133,552	UniSTS	RGSC3.4
Celera	1	194,714,198 - 194,714,338	UniSTS
RH 3.4 Map	1	1437.31	UniSTS
Cytogenetic Map	1	q41	UniSTS

RH143841

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	197,086,648 - 197,086,831 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	214,947,669 - 214,947,851	NCBI	Rnor6.0
Rnor_5.0	1	221,860,815 - 221,860,997	UniSTS	Rnor5.0
RGSC_v3.4	1	202,132,259 - 202,132,441	UniSTS	RGSC3.4
Celera	1	194,713,045 - 194,713,227	UniSTS
Cytogenetic Map	1	q41	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	45	113	65	64	33	25	33	6	188	93	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001419566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590261	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101274	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101278	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101280	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101286	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005499534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005499535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AM040976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027134 ⟹ ENSRNOP00000027134

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	206,465,410 - 206,518,150 (+)	Ensembl
mRatBN7.2 Ensembl	1	197,035,633 - 197,088,092 (+)	Ensembl
Rnor_6.0 Ensembl	1	214,927,172 - 214,947,624 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113212 ⟹ ENSRNOP00000090176

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	206,465,323 - 206,518,150 (+)	Ensembl
mRatBN7.2 Ensembl	1	197,035,633 - 197,088,092 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113716 ⟹ ENSRNOP00000078625

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	206,465,040 - 206,518,156 (+)	Ensembl
mRatBN7.2 Ensembl	1	197,035,633 - 197,088,092 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116048 ⟹ ENSRNOP00000097899

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	206,465,040 - 206,518,156 (+)	Ensembl
mRatBN7.2 Ensembl	1	197,035,633 - 197,088,092 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117225 ⟹ ENSRNOP00000080546

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	206,465,323 - 206,518,150 (+)	Ensembl
mRatBN7.2 Ensembl	1	197,035,633 - 197,088,092 (+)	Ensembl

RefSeq Acc Id:

NM_001419566 ⟹ NP_001406495

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,040 - 206,518,156 (+)	NCBI
mRatBN7.2	1	197,035,505 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_039101272 ⟹ XP_038957200

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,059 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,035,522 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_039101273 ⟹ XP_038957201

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,060 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,035,523 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_039101274 ⟹ XP_038957202

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,060 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,035,523 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_039101275 ⟹ XP_038957203

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,060 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,035,522 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_039101276 ⟹ XP_038957204

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,061 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,035,524 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_039101278 ⟹ XP_038957206

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,062 - 206,516,107 (+)	NCBI
mRatBN7.2	1	197,035,526 - 197,086,573 (+)	NCBI

RefSeq Acc Id:

XM_039101279 ⟹ XP_038957207

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,062 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,035,526 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_039101280 ⟹ XP_038957208

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,062 - 206,516,041 (+)	NCBI
mRatBN7.2	1	197,035,526 - 197,086,505 (+)	NCBI

RefSeq Acc Id:

XM_039101281 ⟹ XP_038957209

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,061 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,035,525 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_039101282 ⟹ XP_038957210

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,495,202 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,065,668 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_039101284 ⟹ XP_038957212

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,062 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,035,526 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_039101285 ⟹ XP_038957213

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,062 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,035,525 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_039101286 ⟹ XP_038957214

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,063 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,035,527 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_039101287 ⟹ XP_038957215

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,499,349 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,069,815 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XM_063286666 ⟹ XP_063142736

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,063 - 206,518,155 (+)	NCBI

RefSeq Acc Id:

XR_005499534

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,062 - 206,518,155 (+)	NCBI
mRatBN7.2	1	197,035,526 - 197,088,624 (+)	NCBI

RefSeq Acc Id:

XR_005499535

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	206,465,062 - 206,516,049 (+)	NCBI
mRatBN7.2	1	197,035,526 - 197,086,517 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001406495	(Get FASTA)	NCBI Sequence Viewer
	XP_038957200	(Get FASTA)	NCBI Sequence Viewer
	XP_038957201	(Get FASTA)	NCBI Sequence Viewer
	XP_038957202	(Get FASTA)	NCBI Sequence Viewer
	XP_038957203	(Get FASTA)	NCBI Sequence Viewer
	XP_038957204	(Get FASTA)	NCBI Sequence Viewer
	XP_038957206	(Get FASTA)	NCBI Sequence Viewer
	XP_038957207	(Get FASTA)	NCBI Sequence Viewer
	XP_038957208	(Get FASTA)	NCBI Sequence Viewer
	XP_038957209	(Get FASTA)	NCBI Sequence Viewer
	XP_038957210	(Get FASTA)	NCBI Sequence Viewer
	XP_038957212	(Get FASTA)	NCBI Sequence Viewer
	XP_038957213	(Get FASTA)	NCBI Sequence Viewer
	XP_038957214	(Get FASTA)	NCBI Sequence Viewer
	XP_038957215	(Get FASTA)	NCBI Sequence Viewer
	XP_063142736	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAJ13860	(Get FASTA)	NCBI Sequence Viewer
	D3ZML2	(Get FASTA)	NCBI Sequence Viewer
	EDM12109	(Get FASTA)	NCBI Sequence Viewer
	EDM12110	(Get FASTA)	NCBI Sequence Viewer
	EDM12111	(Get FASTA)	NCBI Sequence Viewer
	EDM12112	(Get FASTA)	NCBI Sequence Viewer
	EDM12113	(Get FASTA)	NCBI Sequence Viewer
	EDM12114	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027134.7
	ENSRNOP00000078625
	ENSRNOP00000080546
	ENSRNOP00000090176
	ENSRNOP00000097899

Ensembl Acc Id:

ENSRNOP00000027134 ⟸ ENSRNOT00000027134

RefSeq Acc Id:	XP_038957200 ⟸ XM_039101272
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038957203 ⟸ XM_039101275
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I6GM96 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038957201 ⟸ XM_039101273
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038957202 ⟸ XM_039101274
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038957204 ⟸ XM_039101276
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038957209 ⟸ XM_039101281
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_038957213 ⟸ XM_039101285
- Peptide Label:	isoform X11

RefSeq Acc Id:	XP_038957207 ⟸ XM_039101279
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I6ABA6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038957212 ⟸ XM_039101284
- Peptide Label:	isoform X10
- UniProtKB:	A0A8I5ZQ20 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038957206 ⟸ XM_039101278
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I6ABA6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038957208 ⟸ XM_039101280
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I6ABA6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038957214 ⟸ XM_039101286
- Peptide Label:	isoform X12

RefSeq Acc Id:	XP_038957210 ⟸ XM_039101282
- Peptide Label:	isoform X8

RefSeq Acc Id:	XP_038957215 ⟸ XM_039101287
- Peptide Label:	isoform X13

Ensembl Acc Id:

ENSRNOP00000080546 ⟸ ENSRNOT00000117225

Ensembl Acc Id:

ENSRNOP00000097899 ⟸ ENSRNOT00000116048

Ensembl Acc Id:

ENSRNOP00000078625 ⟸ ENSRNOT00000113716

Ensembl Acc Id:

ENSRNOP00000090176 ⟸ ENSRNOT00000113212

RefSeq Acc Id:

NP_001406495 ⟸ NM_001419566

RefSeq Acc Id:	XP_063142736 ⟸ XM_063286666
- Peptide Label:	isoform X9
- UniProtKB:	A0A8I5ZLC7 (UniProtKB/TrEMBL)

Protein Domains

Protein kinase UBA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZML2-F1-model_v2	AlphaFold	D3ZML2	1-735	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566256	AgrOrtholog
BioCyc Gene	G2FUF-56930	BioCyc
Ensembl Genes	ENSRNOG00000020021	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000027134.7	UniProtKB/Swiss-Prot
	ENSRNOT00000113212	ENTREZGENE
	ENSRNOT00000113716	ENTREZGENE
	ENSRNOT00000116048	ENTREZGENE
	ENSRNOT00000117225	ENTREZGENE
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	BRSK1_2-like_UBA	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
NCBI Gene	293631	ENTREZGENE
PANTHER	BR SERINE_THREONINE KINASE 1	UniProtKB/Swiss-Prot
	MAP/MICROTUBULE AFFINITY-REGULATING KINASE	UniProtKB/Swiss-Prot
Pfam	KA1_BRSK	UniProtKB/Swiss-Prot
	Pkinase	UniProtKB/Swiss-Prot
	UBA_BRSK	UniProtKB/Swiss-Prot
PhenoGen	Brsk2	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000020021	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZLC7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZQ20	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ABA6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GM96	ENTREZGENE, UniProtKB/TrEMBL
	A6HY28_RAT	UniProtKB/TrEMBL
	A6HY30_RAT	UniProtKB/TrEMBL
	A6HY31_RAT	UniProtKB/TrEMBL
	A6HY32_RAT	UniProtKB/TrEMBL
	A6HY33_RAT	UniProtKB/TrEMBL
	BRSK2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	M9MMM8_RAT	UniProtKB/TrEMBL
UniProt Secondary	E9PTC7	UniProtKB/Swiss-Prot
	Q4A1P4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Brsk2	BR serine/threonine kinase 2	LOC103691267	uncharacterized LOC103691267	Data merged from RGD:9238521	737654	PROVISIONAL
2014-08-25	LOC103691267	uncharacterized LOC103691267			Symbol and Name status set to provisional	70820	PROVISIONAL
2010-09-23	Brsk2	BR serine/threonine kinase 2	Brsk2	brain serine/threonine kinase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	Brsk2	brain serine/threonine kinase 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar