| 1309022 | Bco2 | beta-carotene oxygenase 2 | ENCODES a protein that exhibits beta,beta-carotene-9',10'-cleaving oxygenase activity (ortholog); oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (ortholog); INVOLVED IN carotene catabolic process (ortholog); carotene meta bolic process (ortholog); carotenoid metabolic process (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 4,4'-sulfonyldiphenol | 8 | 59778571 | 59803597 | Rat | 115 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319131 | BCO2 | beta-carotene oxygenase 2 | This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] | 11 | 112175512 | 112218946 | Human | 118 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1319132 | Bco2 | beta-carotene oxygenase 2 | Enables beta,beta-carotene-9',10'-cleaving oxygenase activity. Involved in isoprenoid catabolic process; regulation of mitochondrial membrane potential; and regulation of reactive oxygen species metabolic process. Acts upstream of or within retinal metabolic process and xanthophyll metabolic process . Located in mitochondrion. Is expressed in brain; embryo; liver; placenta; and yolk sac. Orthologous to human BCO2 (beta-carotene oxygenase 2). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 50444387 | 50466513 | Mouse | 126 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8957718 | Bco2 | beta-carotene oxygenase 2 | ENCODES a protein that exhibits beta,beta-carotene-9',10'-cleaving oxygenase activity (ortholog); oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (ortholog); INVOLVED IN carotene catabolic process (ortholog); carotene meta bolic process (ortholog); carotenoid metabolic process (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN mitochondrion (ortholog) | NW_004955412 | 13838260 | 13872886 | Chinchilla | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11711313 | BCO2 | beta-carotene oxygenase 2 | ENCODES a protein that exhibits beta,beta-carotene-9',10'-cleaving oxygenase activity (inferred); beta-carotene 15,15'-dioxygenase activity (inferred); carotenoid dioxygenase activity (inferred); INVOLVED IN retinal metabolic process (ortholog); xanthophyll metabolic process (ortholog); ASSOCIATED W ITH hepatocellular carcinoma (ortholog); FOUND IN mitochondrion (inferred) | 11 | 107056525 | 107105358 | Bonobo | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12150998 | BCO2 | beta-carotene oxygenase 2 | ENCODES a protein that exhibits 6-pyruvoyltetrahydropterin synthase activity (inferred); beta,beta-carotene-9',10'-cleaving oxygenase activity (inferred); dioxygenase activity (inferred); INVOLVED IN retinal metabolic process (ortholog); xanthophyll metabolic process (ortholog); ASSOCIATED WITH hepa tocellular carcinoma (ortholog); FOUND IN mitochondrion (inferred) | 5 | 20914658 | 20969847 | Dog | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12458146 | Bco2 | beta-carotene oxygenase 2 | ENCODES a protein that exhibits beta,beta-carotene-9',10'-cleaving oxygenase activity (inferred); beta-carotene 15,15'-dioxygenase activity (inferred); carotenoid dioxygenase activity (inferred); INVOLVED IN retinal metabolic process (ortholog); xanthophyll metabolic process (ortholog); ASSOCIATED W ITH hepatocellular carcinoma (ortholog); FOUND IN mitochondrion (inferred) | NW_004936612 | 2262115 | 2294287 | Squirrel | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14059875 | BCO2 | beta-carotene oxygenase 2 | ENCODES a protein that exhibits beta,beta-carotene-9',10'-cleaving oxygenase activity (inferred); dioxygenase activity (inferred); metal ion binding (inferred); INVOLVED IN retinal metabolic process (ortholog); xanthophyll metabolic process (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortho log); FOUND IN mitochondrion (inferred) | | | | Pig | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902736 | Bco2 | beta-carotene oxygenase 2 | ENCODES a protein that exhibits beta,beta-carotene-9',10'-cleaving oxygenase activity (inferred); beta-carotene 15,15'-dioxygenase activity (inferred); carotenoid dioxygenase activity (inferred); INVOLVED IN carotene metabolic process (ortholog); carotenoid metabolic process (ortholog); regulation o f mitochondrial membrane potential (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN mitochondrion (inferred) | | | | Naked Mole-Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18542760 | BCO2 | beta-carotene oxygenase 2 | ENCODES a protein that exhibits beta,beta-carotene-9',10'-cleaving oxygenase activity (inferred); beta-carotene 15,15'-dioxygenase activity (inferred); carotenoid dioxygenase activity (inferred); INVOLVED IN retinal metabolic process (ortholog); xanthophyll metabolic process (ortholog); ASSOCIATED W ITH hepatocellular carcinoma (ortholog); FOUND IN mitochondrion (inferred) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625944455 | Bco2 | beta-carotene oxygenase 2 | ENCODES a protein that exhibits beta,beta-carotene-9',10'-cleaving oxygenase activity (ortholog); oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (ortholog); INVOLVED IN carotene catabolic process (ortholog); carotene meta bolic process (ortholog); carotenoid metabolic process (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN mitochondrion (ortholog) | | | | Black Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246477 | bco2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155246478 | bco2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284234826 | bco2l | | | | | | Tropical Clawed Frog | | symbol | gene, null |