LOC103248467 (beta,beta-carotene 9',10'-oxygenase) - Rat Genome Database

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Gene: LOC103248467 (beta,beta-carotene 9',10'-oxygenase) Chlorocebus sabaeus
Analyze
Symbol: LOC103248467 (Ensembl: BCO2)
Name: beta,beta-carotene 9',10'-oxygenase (Ensembl:beta-carotene oxygenase 2)
RGD ID: 18542760
Description: ENCODES a protein that exhibits beta,beta-carotene-9',10'-cleaving oxygenase activity (inferred); beta-carotene 15,15'-dioxygenase activity (inferred); carotenoid dioxygenase activity (inferred); INVOLVED IN retinal metabolic process (ortholog); xanthophyll metabolic process (ortholog); ASSOCIATED WITH BH4-deficient hyperphenylalaninemia A (ortholog); Chromosome 11, Partial Trisomy 11q (ortholog); hepatocellular carcinoma (ortholog); FOUND IN mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BCO2; beta-carotene oxygenase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,511,730 - 103,566,526 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,521,658 - 103,565,659 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,419,766 - 22,475,321 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LOC103248467
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,511,730 - 103,566,526 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,521,658 - 103,565,659 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,419,766 - 22,475,321 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
BCO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,175,512 - 112,218,946 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,175,510 - 112,224,699 (+)EnsemblGRCh38hg38GRCh38
GRCh3711112,046,235 - 112,089,669 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,551,418 - 111,594,862 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411111,551,567 - 111,594,072NCBI
Celera11109,199,441 - 109,242,886 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,970,380 - 108,015,210 (+)NCBIHuRef
CHM1_111111,929,662 - 111,973,106 (+)NCBICHM1_1
T2T-CHM13v2.011112,185,841 - 112,229,285 (+)NCBIT2T-CHM13v2.0
Bco2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,444,387 - 50,466,513 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,444,387 - 50,466,481 (-)EnsemblGRCm39 Ensembl
GRCm38950,533,087 - 50,555,214 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,533,087 - 50,555,181 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,341,192 - 50,363,243 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,285,381 - 50,302,932 (-)NCBIMGSCv36mm8
Celera947,822,891 - 47,850,079 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.74NCBI
Bco2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,778,571 - 59,803,597 (-)NCBIGRCr8
mRatBN7.2850,882,174 - 50,907,676 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,882,181 - 50,915,467 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,387,689 - 56,412,994 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,666,588 - 54,691,892 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,530,858 - 52,556,168 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0854,965,577 - 54,990,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,965,583 - 54,998,864 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,562,900 - 53,587,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,892,017 - 53,917,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1853,911,481 - 53,932,108 (-)NCBI
Celera850,430,781 - 50,455,782 (-)NCBICelera
Cytogenetic Map8q23NCBI
Bco2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,837,782 - 13,872,886 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,838,260 - 13,872,886 (+)NCBIChiLan1.0ChiLan1.0
BCO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,920,417 - 112,971,307 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111114,015,150 - 114,065,619 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011107,056,525 - 107,105,358 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,899,703 - 110,942,556 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,899,703 - 110,942,547 (+)Ensemblpanpan1.1panPan2
BCO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1520,914,658 - 20,969,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl520,915,647 - 20,964,177 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,838,144 - 20,892,509 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0520,937,599 - 20,992,072 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl520,919,161 - 20,987,893 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,000,542 - 21,054,904 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0520,900,812 - 20,955,168 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0520,948,956 - 20,998,527 (-)NCBIUU_Cfam_GSD_1.0
Bco2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,411,396 - 94,443,419 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,262,066 - 2,294,255 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,262,115 - 2,294,287 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,872,645 - 39,917,263 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,864,136 - 39,916,491 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,716,295 - 44,767,961 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Bco2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,334,472 - 7,353,802 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,324,312 - 7,353,733 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000000838   ⟹   ENSCSAP00000015226
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1103,521,658 - 103,565,659 (+)Ensembl
RefSeq Acc Id: XM_008020871   ⟹   XP_008019062
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11103,520,568 - 103,566,526 (+)NCBI
Vero_WHO_p1.0NW_02366604322,419,766 - 22,463,982 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008020872   ⟹   XP_008019063
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11103,521,666 - 103,565,724 (+)NCBI
Vero_WHO_p1.0NW_02366604322,419,766 - 22,463,909 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038005214   ⟹   XP_037861142
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604322,419,766 - 22,475,321 (-)NCBI
RefSeq Acc Id: XM_038005215   ⟹   XP_037861143
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604322,419,766 - 22,463,748 (-)NCBI
RefSeq Acc Id: XM_038005216   ⟹   XP_037861144
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604322,419,766 - 22,455,960 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008019062 (Get FASTA)   NCBI Sequence Viewer  
  XP_008019063 (Get FASTA)   NCBI Sequence Viewer  
  XP_037861142 (Get FASTA)   NCBI Sequence Viewer  
  XP_037861143 (Get FASTA)   NCBI Sequence Viewer  
  XP_037861144 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000015226.1
RefSeq Acc Id: XP_008019062   ⟸   XM_008020871
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S2Y7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008019063   ⟸   XM_008020872
- Peptide Label: isoform X5
- UniProtKB: A0A0D9S2Y7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000015226   ⟸   ENSCSAT00000000838
RefSeq Acc Id: XP_037861142   ⟸   XM_038005214
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S2Y7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037861143   ⟸   XM_038005215
- Peptide Label: isoform X3
- UniProtKB: A0A0D9S2Y7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037861144   ⟸   XM_038005216
- Peptide Label: isoform X4
- UniProtKB: A0A0D9S2Y7 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002818 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000838.1 UniProtKB/TrEMBL
InterPro Carotenoid_Oase UniProtKB/TrEMBL
NCBI Gene BCO2 ENTREZGENE
PANTHER BETA,BETA-CAROTENE 9',10'-OXYGENASE UniProtKB/TrEMBL
  PTHR10543 UniProtKB/TrEMBL
Pfam RPE65 UniProtKB/TrEMBL
UniProt A0A0D9S2Y7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 LOC103248467  beta,beta-carotene 9',10'-oxygenase  BCO2  beta-carotene oxygenase 2  Symbol and/or name change 5135510 APPROVED