| 1307906 | Get3 | guided entry of tail-anchored proteins factor 3, ATPase | ENCODES a protein that exhibits ATP hydrolysis activity (ortholog); protein carrier chaperone (ortholog); INVOLVED IN tail-anchored membrane protein insertion into ER membrane; ASSOCIATED WITH Dilated Cardiomyopathy 2H (ortholog); prostate cancer (ortholog); FOUND IN GET complex; endoplasmic reticul um membrane (ortholog); nucleolus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acrylamide | 19 | 40034675 | 40043064 | Rat | 101 | ensembl_gene_symbol , old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1317371 | GET3 | guided entry of tail-anchored proteins factor 3, ATPase | This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involv ed in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011] | 19 | 12737106 | 12748323 | Human | 128 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1620065 | Get3 | guided entry of tail-anchored proteins factor 3, ATPase | Predicted to enable ATP hydrolysis activity and membrane insertase activity. Predicted to be involved in tail-anchored membrane protein insertion into ER membrane. Predicted to act upstream of or within post-translational protein targeting to endoplasmic reticulum membrane. Predicted to be located i n nucleolus and nucleoplasm. Predicted to be part of GET complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; foregut; ganglia; respiratory system; and tooth. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). [provided by Alliance of Genome Resources, Apr 2025] | 8 | 85744558 | 85751916 | Mouse | 111 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8855668 | Get3 | guided entry of tail-anchored proteins factor 3, ATPase | ENCODES a protein that exhibits ATP hydrolysis activity (ortholog); protein carrier chaperone (ortholog); INVOLVED IN tail-anchored membrane protein insertion into ER membrane (ortholog); ASSOCIATED WITH Dilated Cardiomyopathy 2H (ortholog); prostate cancer (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); GET complex (ortholog); nucleolus (ortholog) | NW_004955415 | 31836294 | 31843046 | Chinchilla | 22 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11749229 | GET3 | guided entry of tail-anchored proteins factor 3, ATPase | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); hydrolase activity (inferred); INVOLVED IN protein insertion into ER membrane (inferred); tail-anchored membrane protein insertion into ER membrane (inferred); ASSOCIATED WITH Dilated Cardiomyopathy 2H (ortho log); prostate cancer (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | 19 | 12299706 | 12310923 | Bonobo | 34 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12407345 | GET3 | guided entry of tail-anchored proteins factor 3, ATPase | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); hydrolase activity (inferred); INVOLVED IN protein insertion into ER membrane (inferred); tail-anchored membrane protein insertion into ER membrane (inferred); ASSOCIATED WITH Dilated Cardiomyopathy 2H (ortho log); prostate cancer (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | 20 | 49392662 | 49398662 | Dog | 34 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12605243 | Get3 | guided entry of tail-anchored proteins factor 3, ATPase | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); hydrolase activity (inferred); INVOLVED IN protein insertion into ER membrane (inferred); tail-anchored membrane protein insertion into ER membrane (inferred); ASSOCIATED WITH Dilated Cardiomyopathy 2H (ortho log); prostate cancer (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | NW_004936659 | 1851953 | 1858176 | Squirrel | 34 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917437 | Get3 | guided entry of tail-anchored proteins factor 3, ATPase | ENCODES a protein that exhibits protein carrier chaperone (ortholog); INVOLVED IN protein insertion into ER membrane (inferred); tail-anchored membrane protein insertion into ER membrane (inferred); ASSOCIATED WITH Dilated Cardiomyopathy 2H (ortholog); prostate cancer (ortholog); FOUND IN endoplasmi c reticulum membrane (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 30 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18517068 | GET3 | guided entry of tail-anchored proteins factor 3, ATPase | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); hydrolase activity (inferred); INVOLVED IN protein insertion into ER membrane (inferred); tail-anchored membrane protein insertion into ER membrane (inferred); ASSOCIATED WITH Dilated Cardiomyopathy 2H (ortho log); prostate cancer (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | | | | Green Monkey | 34 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 13904547 | GET3 | guided entry of tail-anchored proteins factor 3, ATPase | ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); hydrolase activity (inferred); INVOLVED IN protein insertion into ER membrane (inferred); tail-anchored membrane protein insertion into ER membrane (inferred); ASSOCIATED WITH Dilated Cardiomyopathy 2H (ortho log); prostate cancer (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | | | | Pig | 31 | old_gene_name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 626036053 | Get3 | guided entry of tail-anchored proteins factor 3, ATPase | ENCODES a protein that exhibits ATP hydrolysis activity (ortholog); protein carrier chaperone (ortholog); INVOLVED IN tail-anchored membrane protein insertion into ER membrane (ortholog); ASSOCIATED WITH Dilated Cardiomyopathy 2H (ortholog); prostate cancer (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); GET complex (ortholog); nucleolus (ortholog) | | | | Black Rat | 22 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12084248 | LOC100855696 | ATPase GET3-like | | 12 | 38861529 | 38862614 | Dog | | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 38669447 | LOC112268075 | ATPase Get3-like | | 11 | 47039920 | 47041868 | Human | | old_gene_name | gene, pseudo, MODEL [RefSeq] |
| 13551708 | LOC112441171 | ATPase Get3-like | | 11 | 46990233 | 47000638 | Bonobo | | old_gene_name | gene, pseudo, MODEL [RefSeq] |