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Gene: GET3 (guided entry of tail-anchored proteins factor 3, ATPase) Homo sapiens
Symbol: GET3
Name: guided entry of tail-anchored proteins factor 3, ATPase
Description: This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: arsA arsenite transporter, ATP-binding, homolog 1; arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ARSA-I; ARSA1; arsenical pump-driving ATPase; arsenite-stimulated ATPase; ASNA-I; ASNA1; ATPase ASNA1; golgi to ER traffic 3 homolog; hARSA-I; hASNA-I; MGC3821; transmembrane domain recognition complex 40 kDa ATPase subunit; transmembrane domain recognition complex, 40kDa; TRC40
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381912,737,106 - 12,748,323 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,848,306 - 12,859,137 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,709,306 - 12,720,137 (+)NCBINCBI36hg18NCBI36
Build 341912,709,305 - 12,720,137NCBI
Celera1912,738,017 - 12,748,848 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,421,428 - 12,432,073 (+)NCBIHuRef
CHM1_11912,848,768 - 12,859,600 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GET3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317371
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.