| 2155 | Arpc1b | actin related protein 2/3 complex, subunit 1B | ENCODES a protein that exhibits protein-containing complex binding; actin filament binding (ortholog); structural constituent of cytoskeleton (ortholog); INVOLVED IN response to estradiol; response to estrogen; Arp2/3 complex-mediated actin nucleation (ortholog); PARTICIPATES IN insulin responsive f acilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); combined immunodeficiency (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN tubulobulbar complex; Arp2/3 protein complex (ortholog); cytosol (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol | 12 | 14595939 | 14609501 | Rat | 184 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 736395 | ARPC1B | actin related protein 2/3 complex subunit 1B | This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human A rp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011] | 7 | 99374259 | 99394816 | Human | 239 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736396 | Arpc1b | actin related protein 2/3 complex, subunit 1B | Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Arp2/3 protein complex and tubulobulbar compl ex. Is expressed in central nervous system; early conceptus; genitourinary system; and retina. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; and myelodysplastic syndrome. Orthologous to human ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 145051066 | 145064996 | Mouse | 217 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8701002 | Arpc1b | actin related protein 2/3 complex subunit 1B | ENCODES a protein that exhibits actin filament binding (ortholog); protein-containing complex binding (ortholog); structural constituent of cytoskeleton (ortholog); INVOLVED IN Arp2/3 complex-mediated actin nucleation (ortholog); response to estradiol (ortholog); response to estrogen (ortholog); PAR TICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); combined immunodeficiency (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN Arp2/3 protein complex (ortholog); cytosol (ortholog); tubulobulbar complex (ortholog) | NW_004955460 | 15055753 | 15069093 | Chinchilla | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11685653 | ARPC1B | actin related protein 2/3 complex subunit 1B | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN response to estradiol (ortholog); response to estrogen (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); combined immunodeficiency (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN tubulobulbar complex (ortholog) | 7 | 91348120 | 91368299 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12071131 | ARPC1B | actin related protein 2/3 complex subunit 1B | ENCODES a protein that exhibits actin filament binding (ortholog); protein-containing complex binding (ortholog); structural constituent of cytoskeleton (ortholog); INVOLVED IN response to estradiol (ortholog); response to estrogen (ortholog); PARTICIPATES IN insulin responsive facilitative sugar tr ansporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); combined immunodeficiency (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytosol (ortholog); tubulobulbar complex (ortholog) | 6 | 10192299 | 10198383 | Dog | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12692625 | Arpc1b | actin related protein 2/3 complex subunit 1B | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN response to estradiol (ortholog); response to estrogen (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); combined immunodeficiency (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN tubulobulbar complex (ortholog) | NW_004936750 | 1651026 | 1662208 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231967 | arpc1b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625994960 | Arpc1b | actin related protein 2/3 complex subunit 1B | ENCODES a protein that exhibits actin filament binding (ortholog); protein-containing complex binding (ortholog); structural constituent of cytoskeleton (ortholog); INVOLVED IN Arp2/3 complex-mediated actin nucleation (ortholog); response to estradiol (ortholog); response to estrogen (ortholog); PAR TICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); combined immunodeficiency (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN Arp2/3 protein complex (ortholog); cytosol (ortholog); tubulobulbar complex (ortholog) | | | | Black Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14229395 | ARPC1B | actin related protein 2/3 complex subunit 1B | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN response to estradiol (ortholog); response to estrogen (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); combined immunodeficiency (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN tubulobulbar complex (ortholog) | | | | Pig | 42 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18927607 | Arpc1b | actin related protein 2/3 complex subunit 1B | ENCODES a protein that exhibits actin filament binding (ortholog); protein-containing complex binding (ortholog); structural constituent of cytoskeleton (ortholog); INVOLVED IN response to estradiol (ortholog); response to estrogen (ortholog); PARTICIPATES IN insulin responsive facilitative sugar tr ansporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); combined immunodeficiency (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytosol (ortholog); tubulobulbar complex (ortholog) | | | | Naked Mole-Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18720994 | ARPC1B | actin related protein 2/3 complex subunit 1B | ENCODES a protein that exhibits actin filament binding (ortholog); protein-containing complex binding (ortholog); structural constituent of cytoskeleton (ortholog); INVOLVED IN Arp2/3 complex-mediated actin nucleation (ortholog); response to estradiol (ortholog); response to estrogen (ortholog); PAR TICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH basal cell carcinoma (ortholog); combined immunodeficiency (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN Arp2/3 protein complex (ortholog); cytosol (ortholog); tubulobulbar complex (ortholog) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234310 | arpc1b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231968 | arpc1b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1593499 | Arpc1b-ps1 | actin related protein 2/3 complex, subunit 1B, pseudogene 1 | | 13 | 61846546 | 61849602 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1594661 | Arpc1b-ps2 | actin related protein 2/3 complex, subunit 1B, pseudogene 2 | | 15 | 36017673 | 36018866 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 14995958 | ARPC1BP1 | ARPC1B pseudogene 1 | | 2 | 208360709 | 208361369 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16570399 | AC004922.1 | novel protein, ARPC1A and ARPC1B readthrough | ENCODES a protein that exhibits actin binding (inferred); INVOLVED IN Arp2/3 complex-mediated actin nucleation (inferred); FOUND IN actin cytoskeleton (inferred); Arp2/3 protein complex (inferred); cytoskeleton (inferred) | | | | Human | 6 | name | gene, protein-coding |
| 18765682 | ARPC1A | actin related protein 2/3 complex subunit 1A | ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); INVOLVED IN Arp2/3 complex-mediated actin nucleation (inferred); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; A SSOCIATED WITH pancreatic cancer (ortholog); schizophrenia (ortholog); FOUND IN actin cytoskeleton (inferred); Arp2/3 protein complex (inferred); cytoskeleton (inferred) | | | | Green Monkey | 22 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1344294 | ARPC1A | actin related protein 2/3 complex subunit 1A | This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] | 7 | 99325898 | 99366262 | Human | 93 | description | gene, protein-coding, REVIEWED [RefSeq] |
