ARPC1A (actin related protein 2/3 complex subunit 1A) - Rat Genome Database

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Gene: ARPC1A (actin related protein 2/3 complex subunit 1A) Homo sapiens
Analyze
Symbol: ARPC1A
Name: actin related protein 2/3 complex subunit 1A
RGD ID: 1344294
HGNC Page HGNC:703
Description: Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Located in extracellular exosome. Implicated in pancreatic cancer. Biomarker of schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: actin binding protein (Schizosaccharomyces pombe sop2-like); actin related protein 2/3 complex subunit 1A, 41kDa; actin related protein 2/3 complex, subunit 1A, 41kDa; actin-related protein 2/3 complex subunit 1A; Arc40; epididymis luminal protein 68; epididymis secretory protein Li 307; HEL-68; HEL-S-307; SOP2-like protein; SOP2Hs; SOP2L
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AC079841.1   ARPC1BP1   LOC204800   LOC260421   LOC260422  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,325,898 - 99,366,262 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl799,325,898 - 99,366,262 (+)EnsemblGRCh38hg38GRCh38
GRCh37798,923,521 - 98,963,885 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36798,761,446 - 98,801,821 (+)NCBINCBI36Build 36hg18NCBI36
Build 34798,568,160 - 98,608,538NCBI
Celera793,657,670 - 93,698,057 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,559,314 - 93,599,623 (+)NCBIHuRef
CHM1_1798,853,571 - 98,893,965 (+)NCBICHM1_1
T2T-CHM13v2.07100,564,792 - 100,605,160 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,283,446 - 98,323,834 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer. Laurila E, etal., Genes Chromosomes Cancer. 2009 Apr;48(4):330-9.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Prabakaran S, etal., Mol Psychiatry. 2004 Jul;9(7):684-97, 643.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. Welch MD, etal., J Cell Biol 1997 Jul 28;138(2):375-84.
Additional References at PubMed
PMID:8125298   PMID:8978670   PMID:9359840   PMID:12477932   PMID:12690205   PMID:12853948   PMID:15489334   PMID:15635413   PMID:16344560   PMID:17072959   PMID:17086175   PMID:17353931  
PMID:18187620   PMID:19056867   PMID:19322201   PMID:20570966   PMID:21280222   PMID:21533175   PMID:21873635   PMID:22863883   PMID:22939629   PMID:23376485   PMID:24711643   PMID:24981860  
PMID:26186194   PMID:26344197   PMID:26496610   PMID:26673895   PMID:27609421   PMID:27872092   PMID:28514442   PMID:29117863   PMID:29509190   PMID:30425250   PMID:30554943   PMID:30948266  
PMID:31722399   PMID:31980649   PMID:32130760   PMID:32780723   PMID:32814769   PMID:33001583   PMID:33545068   PMID:33637726   PMID:33947818   PMID:33961781   PMID:34079125   PMID:34709727  
PMID:35013218   PMID:35271311   PMID:35831314   PMID:35871131  


Genomics

Comparative Map Data
ARPC1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,325,898 - 99,366,262 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl799,325,898 - 99,366,262 (+)EnsemblGRCh38hg38GRCh38
GRCh37798,923,521 - 98,963,885 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36798,761,446 - 98,801,821 (+)NCBINCBI36Build 36hg18NCBI36
Build 34798,568,160 - 98,608,538NCBI
Celera793,657,670 - 93,698,057 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,559,314 - 93,599,623 (+)NCBIHuRef
CHM1_1798,853,571 - 98,893,965 (+)NCBICHM1_1
T2T-CHM13v2.07100,564,792 - 100,605,160 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,283,446 - 98,323,834 (+)NCBI
Arpc1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395145,020,679 - 145,045,566 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5145,020,640 - 145,045,571 (+)EnsemblGRCm39 Ensembl
GRCm385145,083,869 - 145,108,756 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5145,083,830 - 145,108,761 (+)EnsemblGRCm38mm10GRCm38
MGSCv375145,844,738 - 145,869,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365145,337,396 - 145,362,283 (+)NCBIMGSCv36mm8
Celera5142,075,658 - 142,100,687 (+)NCBICelera
Cytogenetic Map5G2NCBI
Arpc1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2129,502,496 - 9,525,304 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,502,501 - 9,525,330 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,307,262 - 10,330,326 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01210,930,465 - 10,953,529 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0129,953,893 - 9,976,958 (-)NCBIRnor_WKY
Rnor_6.01211,272,609 - 11,294,084 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,272,609 - 11,294,058 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,341,711 - 13,363,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1129,846,583 - 9,863,837 (-)NCBI
Celera1211,307,305 - 11,329,866 (-)NCBICelera
Cytogenetic Map12p11NCBI
Arpc1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546015,023,221 - 15,051,115 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546015,022,663 - 15,050,955 (+)NCBIChiLan1.0ChiLan1.0
ARPC1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17104,801,399 - 104,841,590 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7104,801,399 - 104,841,590 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0791,299,559 - 91,339,729 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ARPC1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1610,212,203 - 10,245,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl610,212,494 - 10,245,073 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha611,838,931 - 11,871,811 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0610,212,409 - 10,245,315 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl610,212,412 - 10,245,312 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1610,082,332 - 10,115,224 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0610,060,836 - 10,093,722 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0610,294,657 - 10,327,563 (-)NCBIUU_Cfam_GSD_1.0
Arpc1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344138,300,216 - 138,334,198 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367501,611,082 - 1,645,045 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARPC1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl36,197,760 - 6,324,524 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.136,296,257 - 6,324,526 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.236,434,509 - 6,462,700 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARPC1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,793,196 - 13,833,254 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2813,764,945 - 13,825,815 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660702,470,717 - 2,509,959 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arpc1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474032,771,885 - 32,805,516 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474032,771,870 - 32,801,047 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
D7S2721  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37798,946,476 - 98,946,636UniSTSGRCh37
Build 36798,784,412 - 98,784,572RGDNCBI36
Celera793,680,649 - 93,680,809RGD
Cytogenetic Map7q22.1UniSTS
HuRef793,582,293 - 93,582,453UniSTS
CRA_TCAGchr7v2798,306,425 - 98,306,585UniSTS
RH11961  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q22.1UniSTS
HuRef793,563,344 - 93,563,500UniSTS
GeneMap99-GB4 RH Map7510.92UniSTS
SHGC-5612  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q22.1UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1126
Count of miRNA genes:653
Interacting mature miRNAs:722
Transcripts:ENST00000262942, ENST00000432786, ENST00000432884, ENST00000441989, ENST00000463009, ENST00000471960, ENST00000477240
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 6 4
Medium 2439 2880 1725 623 1853 464 4357 2179 3731 417 1454 1609 175 1 1204 2788 6 2
Low 111 1 1 98 1 18 3 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001190996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM924483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA089818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU668326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ472234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y08999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000262942   ⟹   ENSP00000262942
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,325,898 - 99,366,262 (+)Ensembl
RefSeq Acc Id: ENST00000432786   ⟹   ENSP00000408711
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,325,927 - 99,366,226 (+)Ensembl
RefSeq Acc Id: ENST00000463009
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,358,666 - 99,366,214 (+)Ensembl
RefSeq Acc Id: ENST00000471960
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,353,935 - 99,360,242 (+)Ensembl
RefSeq Acc Id: ENST00000477240
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,363,465 - 99,366,262 (+)Ensembl
RefSeq Acc Id: NM_001190996   ⟹   NP_001177925
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,325,898 - 99,366,262 (+)NCBI
GRCh37798,923,496 - 98,963,885 (+)RGD
Celera793,657,670 - 93,698,057 (+)RGD
HuRef793,559,314 - 93,599,623 (+)ENTREZGENE
CHM1_1798,853,571 - 98,893,965 (+)NCBI
T2T-CHM13v2.07100,564,792 - 100,605,160 (+)NCBI
CRA_TCAGchr7v2798,283,446 - 98,323,834 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_006409   ⟹   NP_006400
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,325,898 - 99,366,262 (+)NCBI
GRCh37798,923,496 - 98,963,885 (+)RGD
Build 36798,761,446 - 98,801,821 (+)NCBI Archive
Celera793,657,670 - 93,698,057 (+)RGD
HuRef793,559,314 - 93,599,623 (+)ENTREZGENE
CHM1_1798,853,571 - 98,893,965 (+)NCBI
T2T-CHM13v2.07100,564,792 - 100,605,160 (+)NCBI
CRA_TCAGchr7v2798,283,446 - 98,323,834 (+)ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_006400   ⟸   NM_006409
- Peptide Label: isoform 1
- UniProtKB: Q8IXQ0 (UniProtKB/Swiss-Prot),   Q92747 (UniProtKB/Swiss-Prot),   V9HVZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177925   ⟸   NM_001190996
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: ENSP00000408711   ⟸   ENST00000432786
RefSeq Acc Id: ENSP00000262942   ⟸   ENST00000262942

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q92747-F1-model_v2 AlphaFold Q92747 1-370 view protein structure

Promoters
RGD ID:6805243
Promoter ID:HG_KWN:58782
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_006409,   OTTHUMT00000335909,   UC003UPY.1,   UC010LFU.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36798,761,116 - 98,761,616 (+)MPROMDB
RGD ID:6851234
Promoter ID:EP73415
Type:initiation region
Name:HS_ARPC1A
Description:Actin related protein 2/3 complex, subunit 1A, 41kDa.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36798,761,469 - 98,761,529EPD
RGD ID:6805245
Promoter ID:HG_KWN:58784
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000335910
Position:
Human AssemblyChrPosition (strand)Source
Build 36798,793,311 - 98,793,811 (+)MPROMDB
RGD ID:7211185
Promoter ID:EPDNEW_H11338
Type:initiation region
Name:ARPC1A_1
Description:actin related protein 2/3 complex subunit 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11339  EPDNEW_H11340  EPDNEW_H11341  EPDNEW_H11342  EPDNEW_H11343  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,325,910 - 99,325,970EPDNEW
RGD ID:7211187
Promoter ID:EPDNEW_H11339
Type:initiation region
Name:ARPC1A_4
Description:actin related protein 2/3 complex subunit 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11338  EPDNEW_H11340  EPDNEW_H11341  EPDNEW_H11342  EPDNEW_H11343  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,348,859 - 99,348,919EPDNEW
RGD ID:7211189
Promoter ID:EPDNEW_H11340
Type:initiation region
Name:ARPC1A_5
Description:actin related protein 2/3 complex subunit 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11338  EPDNEW_H11339  EPDNEW_H11341  EPDNEW_H11342  EPDNEW_H11343  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,354,057 - 99,354,117EPDNEW
RGD ID:7211191
Promoter ID:EPDNEW_H11341
Type:initiation region
Name:ARPC1A_6
Description:actin related protein 2/3 complex subunit 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11338  EPDNEW_H11339  EPDNEW_H11340  EPDNEW_H11342  EPDNEW_H11343  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,358,358 - 99,358,418EPDNEW
RGD ID:7211193
Promoter ID:EPDNEW_H11342
Type:initiation region
Name:ARPC1A_2
Description:actin related protein 2/3 complex subunit 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11338  EPDNEW_H11339  EPDNEW_H11340  EPDNEW_H11341  EPDNEW_H11343  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,362,625 - 99,362,685EPDNEW
RGD ID:7211197
Promoter ID:EPDNEW_H11343
Type:initiation region
Name:ARPC1A_3
Description:actin related protein 2/3 complex subunit 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11338  EPDNEW_H11339  EPDNEW_H11340  EPDNEW_H11341  EPDNEW_H11342  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,366,001 - 99,366,061EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q21.3-22.1(chr7:98288474-101259804)x3 copy number gain See cases [RCV000053573] Chr7:98288474..101259804 [GRCh38]
Chr7:97917786..100903085 [GRCh37]
Chr7:97755722..100689805 [NCBI36]
Chr7:7q21.3-22.1
pathogenic
GRCh38/hg38 7q22.1(chr7:99219420-100902269)x1 copy number loss See cases [RCV000054154] Chr7:99219420..100902269 [GRCh38]
Chr7:98817043..100499889 [GRCh37]
Chr7:98654979..100337825 [NCBI36]
Chr7:7q22.1
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q22.1(chr7:99195836-102258175)x1 copy number loss See cases [RCV000135782] Chr7:99195836..102258175 [GRCh38]
Chr7:98793459..101718950 [GRCh37]
Chr7:98631395..101688175 [NCBI36]
Chr7:7q22.1
pathogenic|uncertain significance
GRCh38/hg38 7q22.1(chr7:99195836-100348063)x3 copy number gain See cases [RCV000135630] Chr7:99195836..100348063 [GRCh38]
Chr7:98793459..99945686 [GRCh37]
Chr7:98631395..99783622 [NCBI36]
Chr7:7q22.1
likely benign
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q21.2-22.1(chr7:92445452-99686985)x1 copy number loss Split hand-foot malformation 1 [RCV000656540] Chr7:92445452..99686985 [GRCh37]
Chr7:7q21.2-22.1
pathogenic
GRCh37/hg19 7q22.1(chr7:98847725-102472176)x1 copy number loss not provided [RCV000682904] Chr7:98847725..102472176 [GRCh37]
Chr7:7q22.1
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7q22.1(chr7:98879212-98954815)x1 copy number loss not provided [RCV000845779] Chr7:98879212..98954815 [GRCh37]
Chr7:7q22.1
uncertain significance
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1(chr7:98830439-98953863)x3 copy number gain not provided [RCV000746915] Chr7:98830439..98953863 [GRCh37]
Chr7:7q22.1
benign
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1(chr7:98758955-99368262)x1 copy number loss not provided [RCV000848016] Chr7:98758955..99368262 [GRCh37]
Chr7:7q22.1
uncertain significance
GRCh37/hg19 7q21.12-22.1(chr7:87477185-100333327) copy number gain Isolated Pierre-Robin syndrome [RCV001352649] Chr7:87477185..100333327 [GRCh37]
Chr7:7q21.12-22.1
pathogenic
GRCh37/hg19 7q22.1(chr7:98755291-99886571)x3 copy number gain not provided [RCV001836489] Chr7:98755291..99886571 [GRCh37]
Chr7:7q22.1
uncertain significance
NC_000007.13:g.(?_97816327)_(99382096_?)dup duplication not provided [RCV001916368] Chr7:97816327..99382096 [GRCh37]
Chr7:7q21.3-22.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:703 AgrOrtholog
COSMIC ARPC1A COSMIC
Ensembl Genes ENSG00000241685 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000262942 ENTREZGENE
  ENSP00000262942.5 UniProtKB/Swiss-Prot
  ENSP00000408711.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000262942 ENTREZGENE
  ENST00000262942.10 UniProtKB/Swiss-Prot
  ENST00000432786.5 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000241685 GTEx
HGNC ID HGNC:703 ENTREZGENE
Human Proteome Map ARPC1A Human Proteome Map
InterPro ARC1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARPC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 10552 ENTREZGENE
OMIM 604220 OMIM
PANTHER PTHR10709 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10709:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24997 PharmGKB
PIRSF ARP2/3_su1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ARC1A_HUMAN UniProtKB/Swiss-Prot
  E9PF58_HUMAN UniProtKB/TrEMBL
  Q75MY0_HUMAN UniProtKB/TrEMBL
  Q8IXQ0 ENTREZGENE
  Q92747 ENTREZGENE
  V9HVZ6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A4D276 UniProtKB/Swiss-Prot
  B4DLQ7 UniProtKB/Swiss-Prot
  D6W5S1 UniProtKB/Swiss-Prot
  Q7Z5U8 UniProtKB/Swiss-Prot
  Q86WU5 UniProtKB/Swiss-Prot
  Q8IXQ0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-10 ARPC1A  actin related protein 2/3 complex subunit 1A    actin related protein 2/3 complex, subunit 1A, 41kDa  Symbol and/or name change 5135510 APPROVED