Aire Gene Search Result

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14 records found for search term Aire

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1311139	Aire	autoimmune regulator	ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); identical protein binding (ortholog); INVOLVED IN central tolerance induction to self antigen (ortholog); humoral immune response (ortholog); negative thymic T cell selection (ortholog); PARTICIPATES IN primary ... (more) immunodeficiency pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH abnormal NK cell number; abnormal thymus morphology; alopecia; ASSOCIATED WITH autoimmune polyendocrine syndrome; autoimmune polyendocrine syndrome type 1 (ortholog); candidiasis (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleus (ortholog); INTERACTS WITH acrylamide; bisphenol A; cadmium dichloride	20	10635775	10650709	Rat	129	symbol , PhenoGen	gene, protein-coding, VALIDATED [RefSeq]
1322440	AIRE	autoimmune regulator	This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the ... (more) thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]	21	44285876	44298648	Human	327	symbol , COSMIC , Human Proteome Map , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1322441	Aire	autoimmune regulator	Enables identical protein binding activity. Involved in immune system development; positive regulation of chemokine production; and regulation of thymocyte migration. Acts upstream of or within humoral immune response; negative thymic T cell selection; and positive regulation of transcription by RNA ... (more) polymerase II. Located in cytoplasm; germ cell nucleus; and nuclear body. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study Guillain-Barre syndrome; Sjogren's syndrome; and autoimmune polyendocrine syndrome type 1. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator). [provided by Alliance of Genome Resources, Jul 2025]	10	77865856	77879444	Mouse	240	symbol , old_gene_name , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
9032764	Aire	autoimmune regulator	ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); identical protein binding (ortholog); INVOLVED IN central tolerance induction to self antigen (ortholog); humoral immune response (ortholog); negative thymic T cell selection (ortholog); ASSOCIATED WITH autoimm ... (more) une polyendocrine syndrome (ortholog); autoimmune polyendocrine syndrome type 1 (ortholog); candidiasis (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleus (ortholog)	NW_004955407	41157503	41165032	Chinchilla	37	symbol	gene, protein-coding, MODEL [RefSeq]
11699221	AIRE	autoimmune regulator	ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN humoral immune response (ortholog); negative thymic T cell selection (ortholog); positive regulation of transcription by ... (more) RNA polymerase II (ortholog); ASSOCIATED WITH autoimmune polyendocrine syndrome (ortholog); autoimmune polyendocrine syndrome type 1 (ortholog); candidiasis (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleus (inferred)	21	30543018	30556225	Bonobo	55	symbol	gene, protein-coding, MODEL [RefSeq]
12213909	AIRE	autoimmune regulator	ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); histone binding (inferred); INVOLVED IN humoral immune response (ortholog); negative thymic T cell selection (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH autoimm ... (more) une polyendocrine syndrome (ortholog); autoimmune polyendocrine syndrome type 1 (ortholog); candidiasis (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleus (inferred)	31	38139513	38149294	Dog	63	symbol	gene, protein-coding, MODEL [RefSeq]
12660872	Aire	autoimmune regulator	ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN humoral immune response (ortholog); negative thymic T cell selection (ortholog); positive regulation of transcription by ... (more) RNA polymerase II (ortholog); ASSOCIATED WITH autoimmune polyendocrine syndrome (ortholog); autoimmune polyendocrine syndrome type 1 (ortholog); candidiasis (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleus (inferred)	NW_004936500	125589	137071	Squirrel	47	symbol	gene, protein-coding, MODEL [RefSeq]
626099590	Aire	autoimmune regulator	ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); identical protein binding (ortholog); INVOLVED IN central tolerance induction to self antigen (ortholog); humoral immune response (ortholog); negative thymic T cell selection (ortholog); ASSOCIATED WITH autoimm ... (more) une polyendocrine syndrome (ortholog); autoimmune polyendocrine syndrome type 1 (ortholog); candidiasis (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleus (ortholog)				Black Rat	37	symbol	gene, protein-coding, MODEL [RefSeq]
14262627	AIRE	autoimmune regulator	ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); histone binding (inferred); INVOLVED IN humoral immune response (ortholog); negative thymic T cell selection (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH autoimm ... (more) une polyendocrine syndrome (ortholog); autoimmune polyendocrine syndrome type 1 (ortholog); candidiasis (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleus (inferred)				Pig	63	symbol	gene, protein-coding, MODEL [RefSeq]
18900464	Aire	autoimmune regulator	ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN central tolerance induction to self antigen (ortholog); humoral immune response (ortholog); negative thymi ... (more) c T cell selection (ortholog); ASSOCIATED WITH autoimmune polyendocrine syndrome (ortholog); autoimmune polyendocrine syndrome type 1 (ortholog); candidiasis (ortholog); FOUND IN nuclear body (ortholog)				Naked Mole-Rat	51	symbol	gene, protein-coding, MODEL [RefSeq]
18434515	AIRE	autoimmune regulator	ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN humoral immune response (ortholog); negative thymic T cell selection (ortholog); positive regulation of transcription by ... (more) RNA polymerase II (ortholog); ASSOCIATED WITH autoimmune polyendocrine syndrome (ortholog); autoimmune polyendocrine syndrome type 1 (ortholog); candidiasis (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleus (inferred)				Green Monkey	55	symbol	gene, protein-coding, MODEL [RefSeq]
329329295	aire						Tropical Clawed Frog		symbol	gene, null
329329296	aire.L						African Clawed Frog		symbol	gene, null
38599148	Aire^em1Ang	autoimmune regulator; ZFN induced mutant1, Ang	ASSOCIATED WITH abnormal NK cell number; abnormal thymus morphology; alopecia; ASSOCIATED WITH autoimmune polyendocrine syndrome				Rat	10	symbol , description	gene, allele