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Gene: Aire (autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)) Mus musculus
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Symbol: Aire
Name: autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
Description: Exhibits identical protein binding activity. Involved in several processes, including immune system development; positive regulation of transcription by RNA polymerase II; and regulation of thymocyte migration. Localizes to the cytoplasm and nuclear body. Used to study Guillain-Barre syndrome; Sjogren's syndrome; and autoimmune polyendocrine syndrome type 1. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Orthologous to human AIRE (autoimmune regulator); PARTICIPATES IN primary immunodeficiency pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH D-mannitol; menadione; trimellitic anhydride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: APECED protein homolog; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; autoimmune regulator; autoimmune regulator AIRE1a; MGC123374; MGC123375
Orthologs:
Homo sapiens (human) : AIRE (autoimmune regulator)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Aire (autoimmune regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aire (autoimmune regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : AIRE (autoimmune regulator)
Canis lupus familiaris (dog) : AIRE (autoimmune regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aire (autoimmune regulator)
Sus scrofa (pig) : AIRE (autoimmune regulator)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381078,030,022 - 78,043,610 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371077,492,776 - 77,506,325 (-)NCBIGRCm37mm9NCBIm37
MGSCv361077,433,160 - 77,446,709 (-)NCBImm8
Celera1079,069,025 - 79,082,610 (-)NCBICelera
Cytogenetic Map10 C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Aire
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1322441
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.