| 1309229 | Agpat2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | ENCODES a protein that exhibits 1-acylglycerol-3-phosphate O-acyltransferase activity (ortholog); INVOLVED IN epidermis development; response to xenobiotic stimulus; phosphatidic acid biosynthetic process (ortholog); PARTICIPATES IN glycerolipid metabolic pathway; glycerophospholipid metabolic pathw ay; ASSOCIATED WITH congenital generalized lipodystrophy (ortholog); congenital generalized lipodystrophy type 1 (ortholog); COVID-19 (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; amitrole | 3 | 29814924 | 29826569 | Rat | 166 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1319453 | AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been asso ciated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | 9 | 136673143 | 136687457 | Human | 249 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1319454 | Agpat2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in triglyceride biosynthetic process. Located in endoplasmic reticulum. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respirato ry system; and urinary system. Used to study congenital generalized lipodystrophy type 1. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 26483069 | 26494429 | Mouse | 255 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8892606 | Agpat2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | ENCODES a protein that exhibits 1-acylglycerol-3-phosphate O-acyltransferase activity (ortholog); INVOLVED IN epidermis development (ortholog); phosphatidic acid biosynthetic process (ortholog); positive regulation of cytokine production (ortholog); ASSOCIATED WITH congenital generalized lipodystrop hy (ortholog); congenital generalized lipodystrophy type 1 (ortholog); COVID-19 (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | NW_004955513 | 4142074 | 4145097 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12007251 | AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | ENCODES a protein that exhibits 1-acylglycerol-3-phosphate O-acyltransferase activity (inferred); acyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN epidermis development (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH congenital generalized lip odystrophy (ortholog); congenital generalized lipodystrophy type 1 (ortholog); COVID-19 (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | 9 | 107749195 | 107763033 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12224191 | AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | ENCODES a protein that exhibits 1-acylglycerol-3-phosphate O-acyltransferase activity (inferred); acyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN epidermis development (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH congenital generalized lip odystrophy (ortholog); congenital generalized lipodystrophy type 1 (ortholog); COVID-19 (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | 9 | 48864300 | 48877627 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12487480 | Agpat2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | ENCODES a protein that exhibits 1-acylglycerol-3-phosphate O-acyltransferase activity (inferred); acyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN epidermis development (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH congenital generalized lip odystrophy (ortholog); congenital generalized lipodystrophy type 1 (ortholog); COVID-19 (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | NW_004936669 | 1185204 | 1198972 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257317 | agpat2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14368861 | Agpat2 | | | | | | Fly | | symbol | gene, null |
| 18905017 | Agpat2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | ENCODES a protein that exhibits 1-acylglycerol-3-phosphate O-acyltransferase activity (inferred); acyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN epidermis development (ortholog); positive regulation of cytokine production (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH congenital generalized lipodystrophy (ortholog); congenital generalized lipodystrophy type 1 (ortholog); COVID-19 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | | | | Naked Mole-Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625998457 | Agpat2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | ENCODES a protein that exhibits 1-acylglycerol-3-phosphate O-acyltransferase activity (ortholog); INVOLVED IN epidermis development (ortholog); phosphatidic acid biosynthetic process (ortholog); positive regulation of cytokine production (ortholog); ASSOCIATED WITH congenital generalized lipodystrop hy (ortholog); congenital generalized lipodystrophy type 1 (ortholog); COVID-19 (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18418043 | AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | ENCODES a protein that exhibits 1-acylglycerol-3-phosphate O-acyltransferase activity (inferred); acyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN epidermis development (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH congenital generalized lip odystrophy (ortholog); congenital generalized lipodystrophy type 1 (ortholog); COVID-19 (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14274806 | AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | ENCODES a protein that exhibits 1-acylglycerol-3-phosphate O-acyltransferase activity (inferred); acyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN epidermis development (ortholog); positive regulation of cytokine production (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH congenital generalized lipodystrophy (ortholog); congenital generalized lipodystrophy type 1 (ortholog); COVID-19 (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Pig | 32 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626182142 | agpat2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862174 | agpat2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858907 | agpat2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860307 | agpat2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858276 | agpat2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257318 | agpat2.S | | | | | | African Clawed Frog | | symbol | gene, null |