| 2062 | Grk2 | G protein-coupled receptor kinase 2 | ENCODES a protein that exhibits beta-adrenergic receptor kinase activity; delta-type opioid receptor binding; G protein-coupled receptor binding; INVOLVED IN cellular response to catecholamine stimulus; cellular response to chemokine; cellular response to epidermal growth factor stimulus; PARTICIPAT ES IN dopamine signaling pathway via D2 family of receptors; G protein mediated signaling pathway; somatostatin signaling pathway; ASSOCIATED WITH Burns; congestive heart failure; Diabetic Nephropathies; FOUND IN apical plasma membrane; axon terminus; basolateral plasma membrane; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 1 | 211010259 | 211031013 | Rat | 316 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10111 | Grk2 | G protein-coupled receptor kinase 2 | Enables G protein-coupled receptor kinase activity. Involved in negative regulation of relaxation of smooth muscle. Acts upstream of or within several processes, including desensitization of G protein-coupled receptor signaling pathway; protein phosphorylation; and regulation of the force of heart c ontraction. Located in membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; limb; and mesenchyme derived from neural crest. Orthologous to human GRK2 (G protein-coupled receptor kinase 2). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 4336029 | 4356356 | Mouse | 381 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 731036 | GRK2 | G protein-coupled receptor kinase 2 | This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor pro teins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017] | 11 | 67266473 | 67286556 | Human | 311 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8836503 | Grk2 | G protein-coupled receptor kinase 2 | ENCODES a protein that exhibits beta-adrenergic receptor kinase activity (ortholog); delta-type opioid receptor binding (ortholog); Edg-2 lysophosphatidic acid receptor binding (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); cellular response to catecholamine stimulus (ortholog); cell ular response to chemokine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; ASSOCIATED WITH allergic contact dermatitis (ortholog); asphyxiating thoracic dystrophy (ortholog); bacterial pneumonia (ortholog); FOUND IN apical plasma membrane (ortholog); axon terminus (ortholog); basolateral plasma membrane (ortholog) | NW_004955422 | 18173438 | 18192357 | Chinchilla | 172 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934396 | Grk2 | G protein-coupled receptor kinase 2 | ENCODES a protein that exhibits beta-adrenergic receptor kinase activity (ortholog); delta-type opioid receptor binding (ortholog); Edg-2 lysophosphatidic acid receptor binding (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); cellular response to catecholamine stimulus (ortholog); cell ular response to chemokine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; ASSOCIATED WITH allergic contact dermatitis (ortholog); asphyxiating thoracic dystrophy (ortholog); bacterial pneumonia (ortholog); FOUND IN apical plasma membrane (ortholog); axon terminus (ortholog); basolateral plasma membrane (ortholog) | | | | Naked Mole-Rat | 186 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 13889263 | GRK2 | G protein-coupled receptor kinase 2 | ENCODES a protein that exhibits beta-adrenergic receptor kinase activity (ortholog); delta-type opioid receptor binding (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN cellular response to catecholamine stimulus (ortholog); cellular response to chemokine (ortholog); cellular r esponse to epidermal growth factor stimulus (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; ASSOCIATED WITH allergic contact dermatitis (ortholog); asphyxiating thoracic dystrophy (ortholog); bacterial pneumonia (ortholog); FOUND IN apical plasma membrane (ortholog); axon terminus (ortholog); basolateral plasma membrane (ortholog) | | | | Pig | 190 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |