| 2034 | Adcy4 | adenylate cyclase 4 | ENCODES a protein that exhibits adenylate cyclase activity; G-protein beta/gamma-subunit complex binding; protein kinase C binding (ortholog); INVOLVED IN cAMP biosynthetic process; intracellular signal transduction; adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog ); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; FOUND IN membrane; protein-containing complex; cytoplasm (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-estradiol 3-benzoate | 15 | 33236201 | 33252070 | Rat | 136 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731839 | Adcy4 | adenylate cyclase 4 | Predicted to enable G-protein beta/gamma-subunit complex binding activity; adenylate cyclase activity; and protein kinase C binding activity. Acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in dendrite. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human ADCY4 (adenylate cyclase 4). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 56006513 | 56021552 | Mouse | 136 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736108 | ADCY4 | adenylate cyclase 4 | This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfa ctory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010] | 14 | 24318359 | 24335071 | Human | 131 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9056035 | Adcy4 | adenylate cyclase 4 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); G-protein beta/gamma-subunit complex binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); intracellular signal transduction (ortholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; FOUND IN cytoplasm (ortholog); dendrite (ortholog); membrane (ortholog) | NW_004955409 | 35966529 | 35982839 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11847001 | ADCY4 | adenylate cyclase 4 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); G-protein beta/gamma-subunit complex binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); intracellular signal transduction (o rtholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; FOUND IN membrane (ortholog); protein-containing complex (ortholog) | 14 | 5094899 | 5111603 | Bonobo | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12422392 | ADCY4 | adenylate cyclase 4 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); G-protein beta/gamma-subunit complex binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); intracellular signal transduction (o rtholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; FOUND IN protein-containing complex (ortholog) | 8 | 4288708 | 4304092 | Dog | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12494691 | Adcy4 | adenylate cyclase 4 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); G-protein beta/gamma-subunit complex binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); intracellular signal transduction (o rtholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; FOUND IN membrane (ortholog); protein-containing complex (ortholog) | NW_004936722 | 213916 | 230802 | Squirrel | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914176 | Adcy4 | adenylate cyclase 4 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); G-protein beta/gamma-subunit complex binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); intracellular signal transduction (ortholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; FOUND IN dendrite (ortholog); protein-containing complex (ortholog) | | | | Naked Mole-Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13997449 | ADCY4 | adenylate cyclase 4 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); G-protein beta/gamma-subunit complex binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); intracellular signal transduction (o rtholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; FOUND IN membrane (ortholog); protein-containing complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233156 | adcy4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18573573 | ADCY4 | adenylate cyclase 4 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); G-protein beta/gamma-subunit complex binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); intracellular signal transduction (o rtholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; FOUND IN membrane (ortholog); protein-containing complex (ortholog) | | | | Green Monkey | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626010747 | Adcy4 | adenylate cyclase 4 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); G-protein beta/gamma-subunit complex binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); intracellular signal transduction (ortholog); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; FOUND IN cytoplasm (ortholog); dendrite (ortholog); membrane (ortholog) | | | | Black Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233157 | adcy4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857322 | adcy4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626188523 | adcy4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865123 | adcy4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861859 | adcy4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856583 | adcy4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626180612 | adcy4.S | | | | | | African Clawed Frog | | symbol | gene, null |
