| 2033 | Adarb1 | adenosine deaminase, RNA-specific, B1 | ENCODES a protein that exhibits double-stranded RNA adenosine deaminase activity; double-stranded RNA binding; identical protein binding; INVOLVED IN adenosine to inosine editing; base conversion or substitution editing; mRNA modification; PARTICIPATES IN microRNA pathway; ASSOCIATED WITH obesity; S pinal Cord Injuries; transient cerebral ischemia; FOUND IN nucleoplasm; nucleolus (ortholog); nucleus (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine | 20 | 11222171 | 11350416 | Rat | 241 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 10082 | Adarb1 | adenosine deaminase, RNA-specific, B1 | This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] | 10 | 77126561 | 77254125 | Mouse | 268 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 732582 | ADARB1 | adenosine deaminase RNA specific B1 | This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice s ite. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008] | 21 | 45074578 | 45226563 | Human | 251 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8945726 | Adarb1 | adenosine deaminase RNA specific B1 | ENCODES a protein that exhibits adenosine deaminase activity (ortholog); double-stranded RNA adenosine deaminase activity (ortholog); double-stranded RNA binding (ortholog); INVOLVED IN adenosine to inosine editing (ortholog); base conversion or substitution editing (ortholog); facial nerve morphoge nesis (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955407 | 41886286 | 41962846 | Chinchilla | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11950687 | ADARB1 | adenosine deaminase RNA specific B1 | ENCODES a protein that exhibits double-stranded RNA adenosine deaminase activity (ortholog); double-stranded RNA binding (ortholog); identical protein binding (ortholog); INVOLVED IN adenosine to inosine editing (ortholog); base conversion or substitution editing (ortholog); facial nerve morphogenes is (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog) | 21 | 31374841 | 31532721 | Bonobo | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12219604 | ADARB1 | adenosine deaminase RNA specific B1 | ENCODES a protein that exhibits double-stranded RNA adenosine deaminase activity (ortholog); double-stranded RNA binding (ortholog); identical protein binding (ortholog); INVOLVED IN adenosine to inosine editing (ortholog); base conversion or substitution editing (ortholog); facial nerve morphogenes is (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog) | 31 | 38715529 | 38799353 | Dog | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12605770 | Adarb1 | adenosine deaminase RNA specific B1 | ENCODES a protein that exhibits double-stranded RNA adenosine deaminase activity (ortholog); double-stranded RNA binding (ortholog); identical protein binding (ortholog); INVOLVED IN adenosine to inosine editing (ortholog); base conversion or substitution editing (ortholog); facial nerve morphogenes is (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004936778 | 1056259 | 1137772 | Squirrel | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249407 | adarb1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626072006 | Adarb1 | adenosine deaminase RNA specific B1 | ENCODES a protein that exhibits adenosine deaminase activity (ortholog); double-stranded RNA adenosine deaminase activity (ortholog); double-stranded RNA binding (ortholog); INVOLVED IN adenosine to inosine editing (ortholog); base conversion or substitution editing (ortholog); facial nerve morphoge nesis (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935987 | Adarb1 | adenosine deaminase RNA specific B1 | ENCODES a protein that exhibits double-stranded RNA adenosine deaminase activity (ortholog); double-stranded RNA binding (ortholog); identical protein binding (ortholog); INVOLVED IN adenosine to inosine editing (ortholog); base conversion or substitution editing (ortholog); facial nerve morphogenes is (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18623191 | ADARB1 | adenosine deaminase RNA specific B1 | ENCODES a protein that exhibits double-stranded RNA adenosine deaminase activity (ortholog); double-stranded RNA binding (ortholog); identical protein binding (ortholog); INVOLVED IN adenosine to inosine editing (ortholog); base conversion or substitution editing (ortholog); facial nerve morphogenes is (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Green Monkey | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13983696 | ADARB1 | adenosine deaminase RNA specific B1 | ENCODES a protein that exhibits double-stranded RNA adenosine deaminase activity (ortholog); double-stranded RNA binding (ortholog); identical protein binding (ortholog); INVOLVED IN adenosine to inosine editing (ortholog); base conversion or substitution editing (ortholog); facial nerve morphogenes is (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248103 | adarb1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249406 | adarb1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16565838 | AL022154.1 | adenosine deaminase, RNA-specific, B1 (ADARB1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |