| 1314604 | ABHD12 | abhydrolase domain containing 12, lysophospholipase | This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, moo d, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011] | 20 | 25294743 | 25390835 | Human | 210 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1314605 | Abhd12 | abhydrolase domain containing 12 | Enables lysophospholipase activity; monoacylglycerol lipase activity; and palmitoyl-(protein) hydrolase activity. Involved in lipid catabolic process; protein depalmitoylation; and regulation of inflammatory response. Acts upstream of or within adult walking behavior; phosphatidylserine catabolic pr ocess; and response to auditory stimulus. Located in dendrite cytoplasm and endoplasmic reticulum membrane. Part of AMPA glutamate receptor complex. Used to study PHARC syndrome. Human ortholog(s) of this gene implicated in PHARC syndrome. Orthologous to human ABHD12 (abhydrolase domain containing 12, lysophospholipase). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 150674413 | 150746705 | Mouse | 149 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1562570 | Abhd12 | abhydrolase domain containing 12, lysophospholipase | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); monoacylglycerol lipase activity (ortholog); palmitoyl-(protein) hydrolase activity (ortholog); INVOLVED IN acylglycerol catabolic process (ortholog); adult walking behavior (ortholog); glycerophospholipid catabolic process (o rtholog); ASSOCIATED WITH cone dystrophy (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN AMPA glutamate receptor complex (ortholog); cytoplasm (ortholog); dendrite cytoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 3 | 160119724 | 160179959 | Rat | 138 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8988348 | Abhd12 | abhydrolase domain containing 12, lysophospholipase | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); monoacylglycerol lipase activity (ortholog); palmitoyl-(protein) hydrolase activity (ortholog); INVOLVED IN acylglycerol catabolic process (ortholog); adult walking behavior (ortholog); glycerophospholipid catabolic process (o rtholog); ASSOCIATED WITH cone dystrophy (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN AMPA glutamate receptor complex (ortholog); cytoplasm (ortholog); dendrite cytoplasm (ortholog) | NW_004955415 | 31284947 | 31337703 | Chinchilla | 37 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11685887 | ABHD12 | abhydrolase domain containing 12, lysophospholipase | ENCODES a protein that exhibits glycerophospholipase activity (inferred); hydrolase activity (inferred); monoacylglycerol lipase activity (inferred); INVOLVED IN adult walking behavior (ortholog); phosphatidylserine catabolic process (ortholog); protein depalmitoylation (ortholog); ASSOCIATED WITH c one dystrophy (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN AMPA glutamate receptor complex (inferred); cytoplasm (inferred); dendrite cytoplasm (inferred) | 20 | 25239710 | 25335941 | Bonobo | 43 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12094313 | ABHD12 | abhydrolase domain containing 12, lysophospholipase | ENCODES a protein that exhibits glycerophospholipase activity (inferred); hydrolase activity (inferred); monoacylglycerol lipase activity (inferred); INVOLVED IN adult walking behavior (ortholog); phosphatidylserine catabolic process (ortholog); protein depalmitoylation (ortholog); ASSOCIATED WITH c one dystrophy (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN AMPA glutamate receptor complex (inferred); cytoplasm (inferred); dendrite cytoplasm (inferred) | 23 | 1496183 | 1562738 | Dog | 43 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12723642 | Abhd12 | abhydrolase domain containing 12, lysophospholipase | ENCODES a protein that exhibits glycerophospholipase activity (inferred); hydrolase activity (inferred); monoacylglycerol lipase activity (inferred); INVOLVED IN adult walking behavior (ortholog); phosphatidylserine catabolic process (ortholog); protein depalmitoylation (ortholog); ASSOCIATED WITH c one dystrophy (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN AMPA glutamate receptor complex (inferred); cytoplasm (inferred); dendrite cytoplasm (inferred) | NW_004936620 | 451216 | 531353 | Squirrel | 43 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13989320 | ABHD12 | abhydrolase domain containing 12, lysophospholipase | ENCODES a protein that exhibits glycerophospholipase activity (inferred); hydrolase activity (inferred); monoacylglycerol lipase activity (inferred); INVOLVED IN adult walking behavior (ortholog); phosphatidylserine catabolic process (ortholog); protein depalmitoylation (ortholog); ASSOCIATED WITH c one dystrophy (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN AMPA glutamate receptor complex (inferred); cytoplasm (inferred); dendrite cytoplasm (inferred) | | | | Pig | 43 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18930793 | Abhd12 | abhydrolase domain containing 12, lysophospholipase | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); palmitoyl-(protein) hydrolase activity (ortholog); phosphatidylserine lysophospholipase A1 activity (ortholog); INVOLVED IN acylglycerol catabolic process (ortholog); adult walking behavior (ortholog); glycerophospholipid cata bolic process (ortholog); ASSOCIATED WITH cone dystrophy (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN AMPA glutamate receptor complex (ortholog); cytoplasm (ortholog); dendrite cytoplasm (ortholog) | | | | Naked Mole-Rat | 42 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155235713 | abhd12 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 598133963 | ABHD12 | abhydrolase domain containing 12, lysophospholipase | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); monoacylglycerol lipase activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN acylglycerol catabolic process (ortholog); glycerophospholipid catabolic process (ortholog); monoacylglycer ol catabolic process (ortholog); ASSOCIATED WITH cone dystrophy (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | | | | Green Monkey | 19 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626094756 | Abhd12 | abhydrolase domain containing 12, lysophospholipase | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); monoacylglycerol lipase activity (ortholog); palmitoyl-(protein) hydrolase activity (ortholog); INVOLVED IN acylglycerol catabolic process (ortholog); adult walking behavior (ortholog); glycerophospholipid catabolic process (o rtholog); ASSOCIATED WITH cone dystrophy (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN AMPA glutamate receptor complex (ortholog); cytoplasm (ortholog); dendrite cytoplasm (ortholog) | | | | Black Rat | 37 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155258257 | abhd12.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242108 | abhd12.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 18643069 | LOC103247036 | lysophosphatidylserine lipase ABHD12 | ENCODES a protein that exhibits monoacylglycerol lipase activity (ortholog); palmitoyl-(protein) hydrolase activity (ortholog); phosphatidylserine lysophospholipase A1 activity (ortholog); INVOLVED IN acylglycerol catabolic process (ortholog); adult walking behavior (ortholog); monoacylglycerol cata bolic process (ortholog); ASSOCIATED WITH PHARC syndrome (ortholog); FOUND IN AMPA glutamate receptor complex (ortholog); cytoplasm (ortholog); dendrite cytoplasm (ortholog) | | | | Green Monkey | 19 | name , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12360255 | LOC100685151 | lysophosphatidylserine lipase ABHD12-like | | 23 | 4459193 | 4464605 | Dog | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 1303145 | Abhd12b | abhydrolase domain containing 12B | INTERACTS WITH bisphenol A; 2-hydroxypropanoic acid (ortholog); 3-phenylprop-2-enal (ortholog) | 6 | 94404594 | 94432395 | Rat | 32 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1349841 | ABHD12B | abhydrolase domain containing 12B | Predicted to enable lysophospholipase activity and monoacylglycerol lipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025] | 14 | 50872053 | 50904970 | Human | 33 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1619703 | Abhd12b | abhydrolase domain containing 12B | Predicted to enable lysophospholipase activity and monoacylglycerol lipase activity. Predicted to be involved in monoacylglycerol catabolic process and phosphatidylserine catabolic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ABHD12 ABHD12B (abhydrolase domain containing 12B). [provided by Alliance of Genome Resources, Apr 2025] | 12 | 70200898 | 70236870 | Mouse | 33 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8845808 | Abhd12b | abhydrolase domain containing 12B | | NW_004955409 | 12007471 | 12036999 | Chinchilla | 1 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12000477 | ABHD12B | abhydrolase domain containing 12B | ENCODES a protein that exhibits monoacylglycerol lipase activity (inferred); phosphatidylcholine lysophospholipase A1 activity (inferred); INVOLVED IN monoacylglycerol catabolic process (inferred); phosphatidylserine catabolic process (inferred); FOUND IN endoplasmic reticulum membrane (inferred) | 14 | 31459836 | 31494138 | Bonobo | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12412247 | ABHD12B | abhydrolase domain containing 12B | | 8 | 27239900 | 27264615 | Dog | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12485328 | Abhd12b | abhydrolase domain containing 12B | ENCODES a protein that exhibits monoacylglycerol lipase activity (inferred); phosphatidylcholine lysophospholipase A1 activity (inferred); INVOLVED IN monoacylglycerol catabolic process (inferred); phosphatidylserine catabolic process (inferred); FOUND IN endoplasmic reticulum membrane (inferred) | NW_004936495 | 14728885 | 14753188 | Squirrel | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14070382 | ABHD12B | abhydrolase domain containing 12B | | | | | Pig | 6 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18482717 | ABHD12B | abhydrolase domain containing 12B | ENCODES a protein that exhibits monoacylglycerol lipase activity (inferred); phosphatidylcholine lysophospholipase A1 activity (inferred); INVOLVED IN monoacylglycerol catabolic process (inferred); phosphatidylserine catabolic process (inferred); FOUND IN endoplasmic reticulum membrane (inferred) | | | | Green Monkey | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907078 | Abhd12b | abhydrolase domain containing 12B | ENCODES a protein that exhibits hydrolase activity (inferred); monoacylglycerol lipase activity (inferred); phosphatidylcholine lysophospholipase A1 activity (inferred); INVOLVED IN monoacylglycerol catabolic process (inferred); phosphatidylserine catabolic process (inferred); FOUND IN endoplasmic r eticulum membrane (inferred) | | | | Naked Mole-Rat | 7 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 285292519 | abhd12b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625962432 | Abhd12b | abhydrolase domain containing 12B | | | | | Black Rat | 1 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 626468327 | abhd12b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468848 | abhd12b.L | | | | | | African Clawed Frog | | symbol | gene, null |