ABHD12 (abhydrolase domain containing 12, lysophospholipase) - Rat Genome Database

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Gene: ABHD12 (abhydrolase domain containing 12, lysophospholipase) Pan paniscus
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Symbol: ABHD12
Name: abhydrolase domain containing 12, lysophospholipase
RGD ID: 11685887
Description: ENCODES a protein that exhibits lysophospholipase activity (inferred); monoacylglycerol lipase activity (inferred); palmitoyl-(protein) hydrolase activity (inferred); INVOLVED IN adult walking behavior (ortholog); phosphatidylserine catabolic process (ortholog); protein depalmitoylation (ortholog); ASSOCIATED WITH cone dystrophy (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN AMPA glutamate receptor complex (inferred); cytoplasm (inferred); dendrite cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: abhydrolase domain containing 12; lysophosphatidylserine lipase ABHD12; monoacylglycerol lipase ABHD12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22126,170,550 - 26,266,837 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12026,167,384 - 26,263,661 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02025,239,710 - 25,335,941 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12025,644,824 - 25,741,073 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2025,645,046 - 25,740,943 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ABHD12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22126,170,550 - 26,266,837 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12026,167,384 - 26,263,661 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02025,239,710 - 25,335,941 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12025,644,824 - 25,741,073 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2025,645,046 - 25,740,943 (-)Ensemblpanpan1.1panPan2
ABHD12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382025,294,743 - 25,390,835 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2025,294,742 - 25,390,835 (-)EnsemblGRCh38hg38GRCh38
GRCh372025,275,379 - 25,371,471 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362025,223,379 - 25,319,477 (-)NCBINCBI36Build 36hg18NCBI36
Build 342025,223,379 - 25,319,454NCBI
Celera2025,349,117 - 25,445,220 (-)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2025,232,725 - 25,328,525 (-)NCBIHuRef
CHM1_12025,276,265 - 25,320,544 (-)NCBICHM1_1
T2T-CHM13v2.02025,359,833 - 25,455,939 (-)NCBIT2T-CHM13v2.0
Abhd12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392150,674,413 - 150,746,705 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2150,674,413 - 150,746,661 (-)EnsemblGRCm39 Ensembl
GRCm382150,832,493 - 150,904,779 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2150,832,493 - 150,904,741 (-)EnsemblGRCm38mm10GRCm38
MGSCv372150,658,251 - 150,730,467 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362150,523,934 - 150,534,011 (-)NCBIMGSCv36mm8
Celera2152,065,897 - 152,137,905 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.74NCBI
Abhd12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83160,119,724 - 160,179,959 (-)NCBIGRCr8
mRatBN7.23139,659,315 - 139,719,529 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3139,659,317 - 139,719,564 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3143,555,512 - 143,615,810 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03152,139,257 - 152,199,551 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03149,887,789 - 149,948,059 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03146,630,298 - 146,690,375 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3146,630,299 - 146,690,375 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03152,989,211 - 153,051,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43141,468,888 - 141,530,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3138,421,060 - 138,481,137 (-)NCBICelera
Cytogenetic Map3q41NCBI
Abhd12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,284,947 - 31,337,160 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,284,947 - 31,337,703 (-)NCBIChiLan1.0ChiLan1.0
ABHD12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1231,496,183 - 1,562,738 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl231,496,551 - 1,562,688 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha231,525,725 - 1,592,232 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0231,736,578 - 1,803,088 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl231,736,578 - 1,803,125 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1231,577,308 - 1,643,795 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0231,701,920 - 1,768,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0231,669,411 - 1,735,944 (-)NCBIUU_Cfam_GSD_1.0
Abhd12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640147,030,881 - 147,110,895 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936620451,174 - 531,454 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936620451,216 - 531,353 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABHD12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1730,997,479 - 31,056,312 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11730,997,477 - 31,056,307 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ABHD12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660787,726,486 - 7,748,675 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abhd12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624939213,007 - 273,786 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624939212,910 - 272,112 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000054922   ⟹   ENSPPAP00000032056
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2025,645,046 - 25,740,913 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000054932   ⟹   ENSPPAP00000032066
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2025,645,046 - 25,740,913 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000054936   ⟹   ENSPPAP00000032070
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2025,648,693 - 25,740,943 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000054948   ⟹   ENSPPAP00000032082
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2025,688,726 - 25,740,913 (-)Ensembl
RefSeq Acc Id: XM_034947592   ⟹   XP_034803483
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22126,170,550 - 26,266,823 (-)NCBI
NHGRI_mPanPan12026,167,384 - 26,263,640 (-)NCBI
Mhudiblu_PPA_v02025,239,710 - 25,335,941 (-)NCBI
RefSeq Acc Id: XM_034947593   ⟹   XP_034803484
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22126,175,975 - 26,266,837 (-)NCBI
NHGRI_mPanPan12026,172,808 - 26,263,661 (-)NCBI
Mhudiblu_PPA_v02025,245,140 - 25,335,938 (-)NCBI
RefSeq Acc Id: XM_055104951   ⟹   XP_054960926
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22126,170,550 - 26,266,830 (-)NCBI
NHGRI_mPanPan12026,167,392 - 26,263,632 (-)NCBI
RefSeq Acc Id: XM_055104952   ⟹   XP_054960927
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22126,175,975 - 26,266,824 (-)NCBI
NHGRI_mPanPan12026,172,808 - 26,263,632 (-)NCBI
RefSeq Acc Id: XP_034803483   ⟸   XM_034947592
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BQV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034803484   ⟸   XM_034947593
- Peptide Label: isoform X4
- UniProtKB: A0A2R9BRK6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000032056   ⟸   ENSPPAT00000054922
Ensembl Acc Id: ENSPPAP00000032066   ⟸   ENSPPAT00000054932
Ensembl Acc Id: ENSPPAP00000032070   ⟸   ENSPPAT00000054936
Ensembl Acc Id: ENSPPAP00000032082   ⟸   ENSPPAT00000054948
RefSeq Acc Id: XP_054960926   ⟸   XM_055104951
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054960927   ⟸   XM_055104952
- Peptide Label: isoform X2
Protein Domains
AB hydrolase-1   Serine aminopeptidase S33


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038923 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000054922.1 UniProtKB/TrEMBL
  ENSPPAT00000054932.1 UniProtKB/TrEMBL
  ENSPPAT00000054936.1 UniProtKB/TrEMBL
  ENSPPAT00000054948.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/TrEMBL
  Hydrolase_4 UniProtKB/TrEMBL
NCBI Gene ABHD12 ENTREZGENE
PANTHER ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PTHR12277:SF61 UniProtKB/TrEMBL
Pfam Abhydrolase_1 UniProtKB/TrEMBL
  Hydrolase_4 UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A2R9BQV1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BQW3_PANPA UniProtKB/TrEMBL
  A0A2R9BQY8_PANPA UniProtKB/TrEMBL
  A0A2R9BRK6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-28 ABHD12  abhydrolase domain containing 12, lysophospholipase  ABHD12  abhydrolase domain containing 12  Symbol and/or name change 5135510 APPROVED