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Gene: Abhd12 (abhydrolase domain containing 12, lysophospholipase) Rattus norvegicus

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Symbol:

Abhd12

Name:

abhydrolase domain containing 12, lysophospholipase

RGD ID:

1562570

Description:

Predicted to enable lysophospholipase activity; monoacylglycerol lipase activity; and palmitoyl-(protein) hydrolase activity. Predicted to be involved in glycerolipid catabolic process; protein depalmitoylation; and regulation of inflammatory response. Predicted to act upstream of or within adult walking behavior and response to auditory stimulus. Predicted to be located in dendrite cytoplasm and membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in PHARC syndrome. Orthologous to human ABHD12 (abhydrolase domain containing 12, lysophospholipase); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

2-arachidonoylglycerol hydrolase; 2-arachidonoylglycerol hydrolase ABHD12; abhydrolase domain containing 12; abhydrolase domain-containing protein 12; LOC499913; lysophosphatidylserine lipase ABHD12; monoacylglycerol lipase ABHD12; oxidized phosphatidylserine lipase ABHD12; similar to Protein C20orf22 homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	160,119,724 - 160,179,959 (-)	NCBI		GRCr8
mRatBN7.2	3	139,659,315 - 139,719,529 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	139,659,317 - 139,719,564 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	143,555,512 - 143,615,810 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	152,139,257 - 152,199,551 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	149,887,789 - 149,948,059 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	146,630,298 - 146,690,375 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	146,630,299 - 146,690,375 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	152,989,211 - 153,051,233 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	141,468,888 - 141,530,219 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	138,421,060 - 138,481,137 (-)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Abhd12	Rat	cone dystrophy		ISO	RGD:1314604	8554872	ClinVar Annotator: match by term: Cone dystrophy	ClinVar	PMID:24697911
Abhd12	Rat	fundus dystrophy		ISO	RGD:1314604	8554872	ClinVar Annotator: match by term: Retinal dystrophy	ClinVar	PMID:22938382\|PMID:25741868\|PMID:28041643\|PMID:28492532
Abhd12	Rat	genetic disease		ISO	RGD:1314604	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868\|PMID:28492532
Abhd12	Rat	Hearing Loss		ISO	RGD:1314604	8554872	ClinVar Annotator: match by term: Hearing impairment	ClinVar	PMID:28492532\|PMID:30311386
Abhd12	Rat	optic atrophy		ISO	RGD:1314604	8554872	ClinVar Annotator: match by term: Optic atrophy	ClinVar	PMID:25741868\|PMID:28492532
Abhd12	Rat	PHARC syndrome		ISO	RGD:1314604	8554872	ClinVar Annotator: match by term: ABHD12-related condition \| ClinVar Annotator: match by term: PHARC syndrome	ClinVar	PMID:17576681\|PMID:20797687\|PMID:23806086\|PMID:24088041\|PMID:24697911\|PMID:25741868\|PMID:26141664\|PMID:26257172\|PMID:26467025\|PMID:28041643\|PMID:28492532\|PMID:29571850\|PMID:29625443\|PMID:30311386\|PMID:31690835\|PMID:34085946\|PMID:34573385\|PMID:37803361\|PMID:9536098

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Abhd12	Rat	PHARC syndrome		ISO	RGD:1314604	11554173	CTD Direct Evidence: marker/mechanism	CTD

Imported Disease Annotations - MGI

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Abhd12	Rat	PHARC syndrome		ISS	RGD:1314605	13592920	OMIM:612674	MouseDO

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Abhd12	Rat	PHARC syndrome		ISO	RGD:1314604	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Abhd12	Rat	(+)-schisandrin B	multiple interactions	EXP		6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABHD12 mRNA]	CTD	PMID:31150632
Abhd12	Rat	1,2-dimethylhydrazine	increases expression	ISO	RGD:1314605	6480464	1,2-Dimethylhydrazine results in increased expression of ABHD12 mRNA	CTD	PMID:22206623
Abhd12	Rat	17alpha-ethynylestradiol	affects expression	ISO	RGD:1314605	6480464	Ethinyl Estradiol affects the expression of ABHD12 mRNA	CTD	PMID:17555576
Abhd12	Rat	17beta-estradiol	multiple interactions	ISO	RGD:1314604	6480464	[Estradiol co-treated with Progesterone] results in increased expression of ABHD12 mRNA	CTD	PMID:20660070
Abhd12	Rat	2,3',4,4',5-Pentachlorobiphenyl	increases expression	ISO	RGD:1314605	6480464	2,3',4,4',5-pentachlorobiphenyl results in increased expression of ABHD12 mRNA	CTD	PMID:31388691
Abhd12	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1314605	6480464	Tetrachlorodibenzodioxin affects the expression of ABHD12 mRNA	CTD	PMID:21570461
Abhd12	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of ABHD12 mRNA	CTD	PMID:33387578\|PMID:34747641
Abhd12	Rat	2-arachidonoylglycerol	increases hydrolysis	ISO	RGD:1314605	6480464	ABHD12 protein results in increased hydrolysis of glyceryl 2-arachidonate	CTD	PMID:18096503
Abhd12	Rat	2-hydroxypropanoic acid	decreases expression	ISO	RGD:1314604	6480464	Lactic Acid results in decreased expression of ABHD12 mRNA	CTD	PMID:30851411
Abhd12	Rat	4-hydroxyphenyl retinamide	increases expression	ISO	RGD:1314605	6480464	Fenretinide results in increased expression of ABHD12 mRNA	CTD	PMID:28973697
Abhd12	Rat	acrolein	multiple interactions	ISO	RGD:1314604	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ...	CTD	PMID:32699268
Abhd12	Rat	aflatoxin B1	decreases expression	ISO	RGD:1314605	6480464	Aflatoxin B1 results in decreased expression of ABHD12 mRNA	CTD	PMID:19770486
Abhd12	Rat	alpha-pinene	multiple interactions	ISO	RGD:1314604	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ...	CTD	PMID:32699268
Abhd12	Rat	atrazine	decreases expression	ISO	RGD:1314604	6480464	Atrazine results in decreased expression of ABHD12 mRNA	CTD	PMID:22378314
Abhd12	Rat	beta-lapachone	increases expression	ISO	RGD:1314604	6480464	beta-lapachone results in increased expression of ABHD12 mRNA	CTD	PMID:38218311
Abhd12	Rat	beta-lapachone	decreases expression	ISO	RGD:1314604	6480464	beta-lapachone results in decreased expression of ABHD12 mRNA	CTD	PMID:38218311
Abhd12	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1314605	6480464	Diethylhexyl Phthalate results in increased expression of ABHD12 mRNA	CTD	PMID:33754040
Abhd12	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of ABHD12 mRNA	CTD	PMID:25181051
Abhd12	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of ABHD12 mRNA	CTD	PMID:34947998
Abhd12	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of ABHD12 gene	CTD	PMID:28505145
Abhd12	Rat	Brodifacoum	increases expression	EXP		6480464	bromfenacoum results in increased expression of ABHD12 protein	CTD	PMID:28903499
Abhd12	Rat	cannabidiol	increases expression	ISO	RGD:1314604	6480464	Cannabidiol results in increased expression of ABHD12 mRNA	CTD	PMID:27918106
Abhd12	Rat	carbon nanotube	increases expression	ISO	RGD:1314605	6480464	Nanotubes, Carbon analog results in increased expression of ABHD12 mRNA	CTD	PMID:25554681
Abhd12	Rat	choline	multiple interactions	ISO	RGD:1314605	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ...	CTD	PMID:20938992
Abhd12	Rat	chromium(6+)	affects expression	ISO	RGD:1314605	6480464	chromium hexavalent ion affects the expression of ABHD12 mRNA	CTD	PMID:28472532
Abhd12	Rat	coumestrol	multiple interactions	ISO	RGD:1314604	6480464	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ABHD12 mRNA	CTD	PMID:19167446
Abhd12	Rat	Cuprizon	increases expression	ISO	RGD:1314605	6480464	Cuprizone results in increased expression of ABHD12 mRNA; Cuprizone results in increased expression of ABHD12 more ...	CTD	PMID:30075103
Abhd12	Rat	Cyclopamine	increases expression	ISO	RGD:1314605	6480464	cyclopamine results in increased expression of ABHD12 mRNA	CTD	PMID:33168583
Abhd12	Rat	dibutyl phthalate	increases expression	EXP		6480464	Dibutyl Phthalate results in increased expression of ABHD12 mRNA	CTD	PMID:21266533
Abhd12	Rat	dibutyl phthalate	decreases expression	ISO	RGD:1314605	6480464	Dibutyl Phthalate results in decreased expression of ABHD12 mRNA	CTD	PMID:21266533
Abhd12	Rat	diuron	increases expression	EXP		6480464	Diuron results in increased expression of ABHD12 mRNA	CTD	PMID:21551480
Abhd12	Rat	dorsomorphin	multiple interactions	ISO	RGD:1314604	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Abhd12	Rat	Enterolactone	multiple interactions	ISO	RGD:1314604	6480464	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ABHD12 mRNA	CTD	PMID:19167446
Abhd12	Rat	folic acid	multiple interactions	ISO	RGD:1314605	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ...	CTD	PMID:20938992
Abhd12	Rat	formaldehyde	increases expression	ISO	RGD:1314604	6480464	Formaldehyde results in increased expression of ABHD12 mRNA	CTD	PMID:23649840
Abhd12	Rat	ivermectin	decreases expression	ISO	RGD:1314604	6480464	Ivermectin results in decreased expression of ABHD12 protein	CTD	PMID:32959892
Abhd12	Rat	L-methionine	multiple interactions	ISO	RGD:1314605	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ...	CTD	PMID:20938992
Abhd12	Rat	lead(0)	decreases expression	ISO	RGD:1314604	6480464	Lead results in decreased expression of ABHD12 mRNA	CTD	PMID:19921347
Abhd12	Rat	N-nitrosodiethylamine	multiple interactions	ISO	RGD:1314605	6480464	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ABHD12 mRNA	CTD	PMID:24535843
Abhd12	Rat	nickel sulfate	decreases expression	ISO	RGD:1314604	6480464	nickel sulfate results in decreased expression of ABHD12 mRNA	CTD	PMID:22714537
Abhd12	Rat	nitrates	multiple interactions	ISO	RGD:1314605	6480464	[Particulate Matter results in increased abundance of Nitrates] which results in increased expression of ABHD12 more ...	CTD	PMID:35964746
Abhd12	Rat	okadaic acid	increases expression	ISO	RGD:1314604	6480464	Okadaic Acid results in increased expression of ABHD12 mRNA	CTD	PMID:38832940
Abhd12	Rat	orlistat	decreases activity	ISO	RGD:1314604	6480464	orlistat results in decreased activity of ABHD12 protein	CTD	PMID:18657971
Abhd12	Rat	ozone	multiple interactions	ISO	RGD:1314604	6480464	[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ...	CTD	PMID:32699268
Abhd12	Rat	paracetamol	increases expression	ISO	RGD:1314604	6480464	Acetaminophen results in increased expression of ABHD12 mRNA	CTD	PMID:22230336
Abhd12	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of ABHD12 mRNA	CTD	PMID:33387578
Abhd12	Rat	perfluorooctanoic acid	increases expression	EXP		6480464	perfluorooctanoic acid results in increased expression of ABHD12 protein	CTD	PMID:34958885
Abhd12	Rat	phenobarbital	increases expression	ISO	RGD:1314605	6480464	Phenobarbital results in increased expression of ABHD12 mRNA	CTD	PMID:19482888
Abhd12	Rat	phenobarbital	multiple interactions	ISO	RGD:1314605	6480464	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ABHD12 mRNA; NR1I3 protein affects the more ...	CTD	PMID:19482888\|PMID:24535843
Abhd12	Rat	phenylmercury acetate	increases expression	ISO	RGD:1314604	6480464	Phenylmercuric Acetate results in increased expression of ABHD12 mRNA	CTD	PMID:26272509
Abhd12	Rat	phenylmercury acetate	multiple interactions	ISO	RGD:1314604	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Abhd12	Rat	pirinixic acid	decreases expression	ISO	RGD:1314605	6480464	pirinixic acid results in decreased expression of ABHD12 mRNA	CTD	PMID:17426115
Abhd12	Rat	progesterone	multiple interactions	ISO	RGD:1314604	6480464	[Estradiol co-treated with Progesterone] results in increased expression of ABHD12 mRNA	CTD	PMID:20660070
Abhd12	Rat	rac-lactic acid	decreases expression	ISO	RGD:1314604	6480464	Lactic Acid results in decreased expression of ABHD12 mRNA	CTD	PMID:30851411
Abhd12	Rat	SB 431542	multiple interactions	ISO	RGD:1314604	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Abhd12	Rat	sodium arsenite	decreases expression	ISO	RGD:1314604	6480464	sodium arsenite results in decreased expression of ABHD12 mRNA	CTD	PMID:22714537
Abhd12	Rat	sodium fluoride	decreases expression	ISO	RGD:1314605	6480464	Sodium Fluoride results in decreased expression of ABHD12 protein	CTD	PMID:28918527
Abhd12	Rat	tamoxifen	affects expression	ISO	RGD:1314605	6480464	Tamoxifen affects the expression of ABHD12 mRNA	CTD	PMID:17555576
Abhd12	Rat	temozolomide	decreases expression	ISO	RGD:1314604	6480464	Temozolomide results in decreased expression of ABHD12 mRNA	CTD	PMID:31758290
Abhd12	Rat	tetrachloromethane	multiple interactions	EXP		6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABHD12 mRNA]	CTD	PMID:31150632
Abhd12	Rat	tetrachloromethane	decreases expression	EXP		6480464	Carbon Tetrachloride results in decreased expression of ABHD12 mRNA	CTD	PMID:31150632
Abhd12	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of ABHD12 mRNA	CTD	PMID:34492290
Abhd12	Rat	titanium dioxide	increases methylation	ISO	RGD:1314605	6480464	titanium dioxide results in increased methylation of ABHD12 gene; titanium dioxide results in increased methylation more ...	CTD	PMID:35295148
Abhd12	Rat	titanium dioxide	decreases methylation	ISO	RGD:1314605	6480464	titanium dioxide results in decreased methylation of ABHD12 gene	CTD	PMID:35295148
Abhd12	Rat	triptonide	decreases expression	ISO	RGD:1314605	6480464	triptonide results in decreased expression of ABHD12 mRNA	CTD	PMID:33045310
Abhd12	Rat	troglitazone	increases expression	ISO	RGD:1314605	6480464	troglitazone results in increased expression of ABHD12 mRNA	CTD	PMID:28973697
Abhd12	Rat	valproic acid	affects expression	ISO	RGD:1314605	6480464	Valproic Acid affects the expression of ABHD12 mRNA	CTD	PMID:17292431
Abhd12	Rat	valproic acid	increases expression	ISO	RGD:1314604	6480464	Valproic Acid results in increased expression of ABHD12 mRNA	CTD	PMID:23179753\|PMID:24383497\|PMID:25192806\|PMID:26272509\|PMID:27188386
Abhd12	Rat	valproic acid	multiple interactions	ISO	RGD:1314604	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Abhd12	Rat	valproic acid	affects expression	ISO	RGD:1314604	6480464	Valproic Acid affects the expression of ABHD12 mRNA	CTD	PMID:25979313
Abhd12	Rat	valproic acid	increases methylation	ISO	RGD:1314604	6480464	Valproic Acid results in increased methylation of ABHD12 gene	CTD	PMID:29154799
Abhd12	Rat	vorinostat	increases expression	ISO	RGD:1314604	6480464	vorinostat results in increased expression of ABHD12 mRNA	CTD	PMID:27188386

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Abhd12	Rat	acylglycerol catabolic process	involved_in	ISO	RGD:1314605	1624291	PMID:18096503	RGD	PMID:18096503
Abhd12	Rat	acylglycerol catabolic process	involved_in	ISO	RGD:1314604	1624291	PMID:22969151	RGD	PMID:22969151
Abhd12	Rat	acylglycerol catabolic process	involved_in	ISS	UniProtKB:Q99LR1	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	adult walking behavior	acts_upstream_of_or_within	ISO	RGD:1314605	1624291	MGI:5487621 PMID:23297193	RGD	PMID:23297193
Abhd12	Rat	glycerophospholipid catabolic process	involved_in	ISO	RGD:1314604	1624291	PMID:25290914	RGD	PMID:25290914
Abhd12	Rat	lipid metabolic process	involved_in	IEA	UniProtKB-KW:KW-0443	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Abhd12	Rat	macromolecule depalmitoylation	involved_in	IEA	GO:0008474	1600115	GO_REF:0000108	GOC	GO_REF:0000108
Abhd12	Rat	monoacylglycerol catabolic process	involved_in	ISS	UniProtKB:Q99LR1	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	monoacylglycerol catabolic process	involved_in	ISO	RGD:1314605	1624291	PMID:30237167	RGD	PMID:30237167
Abhd12	Rat	monoacylglycerol catabolic process	involved_in	IBA	MGI:1923442\|PANTHER:PTN000957701\|UniProtKB:Q8N2K0	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Abhd12	Rat	monoacylglycerol catabolic process	involved_in	ISO	RGD:1314604	1624291	PMID:25290914, PMID:30237167	RGD	PMID:25290914\|PMID:30237167
Abhd12	Rat	monoacylglycerol catabolic process	involved_in	ISS	UniProtKB:Q8N2K0	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	phosphatidylserine catabolic process	involved_in	ISS	UniProtKB:Q8N2K0	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	phosphatidylserine catabolic process	acts_upstream_of_or_within	ISO	RGD:1314605	1624291	MGI:5487621 PMID:23297193	RGD	PMID:23297193
Abhd12	Rat	phosphatidylserine catabolic process	involved_in	IBA	MGI:1923442\|PANTHER:PTN000957701\|UniProtKB:Q8N2K0	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Abhd12	Rat	phosphatidylserine catabolic process	involved_in	ISO	RGD:1314604	1624291	PMID:30643283	RGD	PMID:30643283
Abhd12	Rat	phospholipid catabolic process	involved_in	ISS	UniProtKB:Q8N2K0	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	phospholipid catabolic process	involved_in	ISO	RGD:1314605	1624291	PMID:25580854, PMID:30237167	RGD	PMID:25580854\|PMID:30237167
Abhd12	Rat	phospholipid catabolic process	involved_in	ISO	RGD:1314604	1624291	PMID:30237167	RGD	PMID:30237167
Abhd12	Rat	phospholipid catabolic process	involved_in	ISS	UniProtKB:Q99LR1	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	protein depalmitoylation	involved_in	ISO	RGD:1314605	1624291	PMID:27307232	RGD	PMID:27307232
Abhd12	Rat	regulation of inflammatory response	involved_in	ISO	RGD:1314605	1624291	PMID:30643283	RGD	PMID:30643283
Abhd12	Rat	response to auditory stimulus	acts_upstream_of_or_within	ISO	RGD:1314605	1624291	MGI:5487621 PMID:23297193	RGD	PMID:23297193

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Abhd12	Rat	AMPA glutamate receptor complex	part_of	ISO	RGD:1314605	1624291	PMID:22632720	RGD	PMID:22632720
Abhd12	Rat	cytoplasm	located_in	ISO	RGD:1314605	1624291	PMID:27307232	RGD	PMID:27307232
Abhd12	Rat	dendrite cytoplasm	located_in	ISO	RGD:1314605	1624291	PMID:27307232	RGD	PMID:27307232
Abhd12	Rat	endoplasmic reticulum	located_in	IEA	UniProtKB-KW:KW-0256	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Abhd12	Rat	endoplasmic reticulum membrane	located_in	ISS	UniProtKB:Q99LR1	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	endoplasmic reticulum membrane	is_active_in	IBA	MGI:1923442\|PANTHER:PTN000957701\|UniProtKB:Q8N2K0	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Abhd12	Rat	endoplasmic reticulum membrane	located_in	ISO	RGD:1314605	1624291	PMID:30237167	RGD	PMID:30237167
Abhd12	Rat	endoplasmic reticulum membrane	located_in	IEA	UniProtKB-SubCell:SL-0097	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Abhd12	Rat	endoplasmic reticulum membrane	located_in	ISO	RGD:1314604	1624291	PMID:30237167	RGD	PMID:30237167
Abhd12	Rat	endoplasmic reticulum membrane	located_in	ISS	UniProtKB:Q8N2K0	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	membrane	located_in	ISO	RGD:1314605	1624291	PMID:18096503	RGD	PMID:18096503
Abhd12	Rat	membrane	located_in	ISS	UniProtKB:Q99LR1	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Abhd12	Rat	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Abhd12	Rat	lysophospholipase activity	enables	ISS	UniProtKB:Q8N2K0	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	lysophospholipase activity	enables	IBA	MGI:1923442\|PANTHER:PTN000957701\|UniProtKB:Q8N2K0	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Abhd12	Rat	lysophospholipase activity	enables	ISO	RGD:1314605	1624291	PMID:25580854, PMID:30237167	RGD	PMID:25580854\|PMID:30237167
Abhd12	Rat	lysophospholipase activity	enables	ISO	RGD:1314604	1624291	PMID:25290914, PMID:30237167	RGD	PMID:25290914\|PMID:30237167
Abhd12	Rat	lysophospholipase activity	enables	ISS	UniProtKB:Q99LR1	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	monoacylglycerol lipase activity	enables	ISS	UniProtKB:Q99LR1	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	monoacylglycerol lipase activity	enables	IEA	EC:3.1.1.23	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Abhd12	Rat	monoacylglycerol lipase activity	enables	IBA	MGI:1923442\|PANTHER:PTN000957701\|UniProtKB:Q8N2K0	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Abhd12	Rat	monoacylglycerol lipase activity	enables	ISO	RGD:1314604	1624291	PMID:22969151, PMID:25290914, PMID:30237167	RGD	PMID:22969151\|PMID:25290914\|PMID:30237167
Abhd12	Rat	monoacylglycerol lipase activity	enables	ISO	RGD:1314605	1624291	PMID:18096503, PMID:23297193, PMID:30237167	RGD	PMID:18096503\|PMID:23297193\|PMID:30237167
Abhd12	Rat	monoacylglycerol lipase activity	enables	ISS	UniProtKB:Q8N2K0	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	palmitoyl-(protein) hydrolase activity	enables	ISO	RGD:1314605	1624291	PMID:27307232	RGD	PMID:27307232
Abhd12	Rat	phospholipase activity	enables	ISS	UniProtKB:Q8N2K0	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Abhd12	Rat	phospholipase activity	enables	ISO	RGD:1314604	1624291	PMID:30643283	RGD	PMID:30643283

Disease Annotations Click to see Annotation Detail View

cone dystrophy (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

Hearing Loss (ISO)

optic atrophy (ISO)

PHARC syndrome (ISO,ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-arachidonoylglycerol (ISO)

2-hydroxypropanoic acid (ISO)

4-hydroxyphenyl retinamide (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

atrazine (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

Brodifacoum (EXP)

cannabidiol (ISO)

carbon nanotube (ISO)

choline (ISO)

chromium(6+) (ISO)

coumestrol (ISO)

Cuprizon (ISO)

Cyclopamine (ISO)

dibutyl phthalate (EXP,ISO)

diuron (EXP)

dorsomorphin (ISO)

Enterolactone (ISO)

folic acid (ISO)

formaldehyde (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

N-nitrosodiethylamine (ISO)

nickel sulfate (ISO)

nitrates (ISO)

okadaic acid (ISO)

orlistat (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

triptonide (ISO)

troglitazone (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acylglycerol catabolic process (ISO,ISS)

adult walking behavior (ISO)

glycerophospholipid catabolic process (ISO)

lipid metabolic process (IEA)

macromolecule depalmitoylation (IEA)

monoacylglycerol catabolic process (IBA,ISO,ISS)

phosphatidylserine catabolic process (IBA,ISO,ISS)

phospholipid catabolic process (ISO,ISS)

protein depalmitoylation (ISO)

regulation of inflammatory response (ISO)

response to auditory stimulus (ISO)

Cellular Component

AMPA glutamate receptor complex (ISO)

cytoplasm (ISO)

dendrite cytoplasm (ISO)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IBA,IEA,ISO,ISS)

membrane (IEA,ISO,ISS)

Molecular Function

hydrolase activity (IEA)

lysophospholipase activity (IBA,ISO,ISS)

monoacylglycerol lipase activity (IBA,IEA,ISO,ISS)

palmitoyl-(protein) hydrolase activity (ISO)

phospholipase activity (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:18096503	PMID:22632720	PMID:22969151	PMID:23297193	PMID:25290914	PMID:25580854	PMID:27307232	PMID:30237167	PMID:30643283

Genomics

Comparative Map Data

Abhd12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	160,119,724 - 160,179,959 (-)	NCBI		GRCr8
mRatBN7.2	3	139,659,315 - 139,719,529 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	139,659,317 - 139,719,564 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	143,555,512 - 143,615,810 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	152,139,257 - 152,199,551 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	149,887,789 - 149,948,059 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	146,630,298 - 146,690,375 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	146,630,299 - 146,690,375 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	152,989,211 - 153,051,233 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	141,468,888 - 141,530,219 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	138,421,060 - 138,481,137 (-)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

ABHD12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	25,294,743 - 25,390,835 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	25,294,742 - 25,390,835 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	25,275,379 - 25,371,471 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	25,223,379 - 25,319,477 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	25,223,379 - 25,319,454	NCBI
Celera	20	25,349,117 - 25,445,220 (-)	NCBI		Celera
Cytogenetic Map	20	p11.21	NCBI
HuRef	20	25,232,725 - 25,328,525 (-)	NCBI		HuRef
CHM1_1	20	25,276,265 - 25,320,544 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	25,359,833 - 25,455,939 (-)	NCBI		T2T-CHM13v2.0

Abhd12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	150,674,413 - 150,746,705 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	150,674,413 - 150,746,661 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	150,832,493 - 150,904,779 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	150,832,493 - 150,904,741 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	150,658,251 - 150,730,467 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	150,523,934 - 150,534,011 (-)	NCBI		MGSCv36	mm8
Celera	2	152,065,897 - 152,137,905 (-)	NCBI		Celera
Cytogenetic Map	2	G3	NCBI
cM Map	2	74.74	NCBI

Abhd12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	31,284,947 - 31,337,160 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	31,284,947 - 31,337,703 (-)	NCBI	ChiLan1.0	ChiLan1.0

ABHD12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	26,170,550 - 26,266,837 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	26,167,384 - 26,263,661 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	25,239,710 - 25,335,941 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	25,644,824 - 25,741,073 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	25,645,046 - 25,740,943 (-)	Ensembl	panpan1.1		panPan2

ABHD12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	1,496,183 - 1,562,738 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	1,496,551 - 1,562,688 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	1,525,725 - 1,592,232 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	1,736,578 - 1,803,088 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	1,736,578 - 1,803,125 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	1,577,308 - 1,643,795 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	1,701,920 - 1,768,413 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	1,669,411 - 1,735,944 (-)	NCBI		UU_Cfam_GSD_1.0

Abhd12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	147,030,881 - 147,110,895 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936620	451,174 - 531,454 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936620	451,216 - 531,353 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ABHD12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	30,997,479 - 31,056,312 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	30,997,477 - 31,056,307 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LOC103247036
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666078	7,726,486 - 7,748,675 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Abhd12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624939	213,007 - 273,786 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624939	212,910 - 272,112 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Abhd12
204 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	103
Count of miRNA genes:	74
Interacting mature miRNAs:	90
Transcripts:	ENSRNOT00000010641
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	121056165	145956249	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat

Markers in Region

AA924737

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	139,659,352 - 139,659,533 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	146,630,336 - 146,630,516	NCBI	Rnor6.0
Rnor_5.0	3	152,989,249 - 152,989,429	UniSTS	Rnor5.0
RGSC_v3.4	3	141,468,926 - 141,469,106	UniSTS	RGSC3.4
Celera	3	138,421,098 - 138,421,278	UniSTS
RH 3.4 Map	3	1196.12	UniSTS
Cytogenetic Map	3	q41	UniSTS

RH140375

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	160,176,217 - 160,176,359 (+)	Marker Load Pipeline
mRatBN7.2	3	139,715,810 - 139,715,952 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	146,686,923 - 146,687,064	NCBI	Rnor6.0
Rnor_5.0	3	153,047,781 - 153,047,922	UniSTS	Rnor5.0
RGSC_v3.4	3	141,525,601 - 141,525,742	UniSTS	RGSC3.4
Celera	3	138,477,426 - 138,477,567	UniSTS
RH 3.4 Map	3	1196.11	UniSTS
Cytogenetic Map	3	q41	UniSTS

BF414488

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	139,665,302 - 139,666,791 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	146,636,286 - 146,637,774	NCBI	Rnor6.0
Rnor_5.0	3	152,995,199 - 152,996,687	UniSTS	Rnor5.0
RGSC_v3.4	3	141,474,876 - 141,476,364	UniSTS	RGSC3.4
Celera	3	138,427,048 - 138,428,536	UniSTS
RH 3.4 Map	3	1195.21	UniSTS
Cytogenetic Map	3	q41	UniSTS

Expression

RNA-SEQ Expression

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alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010064685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC078918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000010641 ⟹ ENSRNOP00000010640

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	139,659,317 - 139,719,564 (-)	Ensembl
Rnor_6.0 Ensembl	3	146,630,299 - 146,690,375 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098567 ⟹ ENSRNOP00000091747

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	139,689,132 - 139,719,488 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111107 ⟹ ENSRNOP00000097732

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	139,661,092 - 139,719,564 (-)	Ensembl

RefSeq Acc Id:

NM_001024314 ⟹ NP_001019485

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	160,119,724 - 160,179,929 (-)	NCBI
mRatBN7.2	3	139,659,315 - 139,719,522 (-)	NCBI
Rnor_6.0	3	146,630,298 - 146,690,375 (-)	NCBI
Rnor_5.0	3	152,989,211 - 153,051,233 (-)	NCBI
RGSC_v3.4	3	141,468,888 - 141,530,219 (-)	RGD
Celera	3	138,421,060 - 138,481,137 (-)	RGD

Sequence:

show sequence

GGCGCTGGTCCTAGCGGGCGCCGCGGCCTGGGGCTGGGGATGTGACCAGCAGTGGGCTCCCAGC
TCCGGGTGGTGACGGCTGTGAGCGACGGCGACTGCGGCGCAGGCGTGCGGTCGAAACCAGGGTG
CGGAAAGCTGCCGGCCGACAGGGCCGCGGGATGAGGAAGCGGACCGAGCCCGTCACCTTGGAGC
ATGAGCGCTGCGCCGCCTCAGGCTCGTCTTCCTCCGGCTCGGCCGCCGCGGCGCTGGACGCCGA
CTGCAGCTTGAAGCAGAACCTGCGTCTGGCGGGCAAGGGGACGGCAGAGCCGCACAGCGCATCC
GACGCGGGCATGAAGCGGGCTCTGGGCAGACGGAAGAGCCTGTGGTTCCGACTAAGGAAGATAC
TTCTCTGTGTTTTGGGGTTCTACATTGCCATTCCATTTCTTGTCAAACTGTGTCCTGGGATACA
GGCCAAACTGATATTCTTAAATTTCGTGAGGGTTCCCTATTTCATTGACTTAAAAAAGCCACAG
GATCAAGGTTTGAATCACACCTGCAATTACTACCTCCAGCCCGAGGATGATGTCACTATTGGAG
TCTGGCACACCATTCCCTCTGTCTGGTGGAAGAATGCCCAAGGGAAGGACCAGATGTGGTATGA
GGATGCTCTGGCTTCTAACCACCCCATCATCCTGTACCTGCATGGGAATGCAGGCACCAGAGGA
GGTGACCACCGTGTGGAGCTGTACAAGGTGCTGAGTTCCCTTGGTTACCACGTGGTCACCTTCG
ACTACAGAGGTTGGGGTGACTCAGTAGGAACACCATCAGAGCGAGGCATGACATATGATGCACT
CCATGTTTTTGACTGGATCAAAGCAAGAAGTGGTGATAATCCTGTGTATATCTGGGGCCATTCG
CTGGGCACTGGAGTGGCAACAAATCTGGTCCGGCGCCTTTGTGAGCGAGAGACGCCACCAGATG
CCCTTATATTGGAGTCTCCGTTCACAAATATTCGTGAAGAAGCAAAGAGTCATCCATTTTCAGT
GATATACAGATACTTCCCAGGCTTTGACTGGTTCTTCCTCGACCCCATTACAAGCAGTGGAATT
AAATTTGCAAATGACGAAAACATGAAGCACATCTCCTGTCCCCTGCTCATCTTGCACGCTGAGG
ATGACCCAGTTGTACCCTTTCATCTCGGCAGGAAGCTATACAATATTGCTGCGCCATCCCGAAG
TTTCCGAGACTTCAAAGTCCAGTTCATCCCCTTTCACTCAGACCTTGGCTACAGACATAAGTAC
ATCTACAAGAGCCCAGAGCTTCCACGGATACTGAGGGAATTCCTAGGGAAGTCGGAACCAGAGC
GCCAGCACTGAGCCTGGCCCGTGAAGGAGCATGGAGACCCACCTTCCTTCCCTTCTCCCTGAAC
AGCAGTCTGGCACCCAGAAGCTCAGAGTGCCACCACCTGTGGTGCTCAGGAGCCCAGCGCATAC
CTAGAAAGAGGACTCCGACACAGCGGGCAGAGGCTCCACAGACGGATCTATGAGGAAAATACGG
TGGCAGGCAGGCAGGCAGGCGACCCCCTGACCCTCTGGTGGCCGCTGTATCTGAGCCCTTTTGG
GAAGGCTTATAGACAACAGGTGGAGCCCATACGCTGGGCATAGGGAGCCTGGGAAGGGCTCAGG
AGCTCAGGACCACTCCAGGCTCTCTAGCACCACCGCTTAAAATACAGGAAAAAGGTTCTTTCTG
CCCTTCCTGGCGTACACAGAACAGATTCCAAGTGGTTCAATTTGTCCCCTACAGCTCATGTACC
TGCTTGCCTTCCTCAGCTGTCCCTGCCTCTCCTGGCATCTGTACACCCACAGTGAGGGGCACCT
GGACTTGCACTTCCATTCTGCCCACCTGTCTGTCACCTAACCTGGCCGTAGACTGAGCATTTAT
TTAAGAATAAAATCTCGGTGGTGGTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063284387 ⟹ XP_063140457

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	160,121,505 - 160,179,959 (-)	NCBI

RefSeq Acc Id:

XR_010064685

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	160,122,500 - 160,179,935 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001019485	(Get FASTA)	NCBI Sequence Viewer
	XP_063140457	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78918	(Get FASTA)	NCBI Sequence Viewer
	EDL86133	(Get FASTA)	NCBI Sequence Viewer
	EDL86134	(Get FASTA)	NCBI Sequence Viewer
	EDL86135	(Get FASTA)	NCBI Sequence Viewer
	EDL86136	(Get FASTA)	NCBI Sequence Viewer
	EDL86137	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010640
	ENSRNOP00000010640.5
GenBank Protein	Q6AYT7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001019485 ⟸ NM_001024314

- UniProtKB:

Q6AYT7 (UniProtKB/Swiss-Prot), A0A8I6ATI5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAGKGTAEPHSASDAGMKRALGR
RKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNY
YLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWYEDALASNHPIILYLHGNAGTRGGDHRVELYKV
LSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLV
RRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKH
ISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRI
LREFLGKSEPERQH

hide sequence

Ensembl Acc Id:

ENSRNOP00000010640 ⟸ ENSRNOT00000010641

Ensembl Acc Id:

ENSRNOP00000091747 ⟸ ENSRNOT00000098567

Ensembl Acc Id:

ENSRNOP00000097732 ⟸ ENSRNOT00000111107

RefSeq Acc Id:	XP_063140457 ⟸ XM_063284387
- Peptide Label:	isoform X1
- UniProtKB:	A6KHH2 (UniProtKB/TrEMBL)

Protein Domains

AB hydrolase-1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AYT7-F1-model_v2	AlphaFold	Q6AYT7	1-398	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692519

Promoter ID:

EPDNEW_R3044

Type:

initiation region

Name:

Abhd12_1

Description:

abhydrolase domain containing 12

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	146,690,324 - 146,690,384	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562570	AgrOrtholog
BioCyc Gene	G2FUF-47336	BioCyc
Ensembl Genes	ENSRNOG00000036934	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000010641	ENTREZGENE
	ENSRNOT00000010641.6	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.1820	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7096446	IMAGE-MGC_LOAD
InterPro	AB_hydrolase	UniProtKB/Swiss-Prot
	AB_hydrolase_1	UniProtKB/Swiss-Prot
KEGG Report	rno:499913	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93694	IMAGE-MGC_LOAD
NCBI Gene	499913	ENTREZGENE
PANTHER	ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
	PTHR12277:SF61	UniProtKB/Swiss-Prot
Pfam	Abhydrolase_1	UniProtKB/Swiss-Prot
PhenoGen	Abhd12	PhenoGen
RatGTEx	ENSRNOG00000036934	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/Swiss-Prot
UniProt	A0A8I6ACA9_RAT	UniProtKB/TrEMBL
	A0A8I6ATI5	ENTREZGENE, UniProtKB/TrEMBL
	A6KHH2	ENTREZGENE, UniProtKB/TrEMBL
	ABD12_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-02-13	Abhd12	abhydrolase domain containing 12, lysophospholipase	Abhd12	abhydrolase domain containing 12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Abhd12	abhydrolase domain containing 12	LOC499913	similar to Protein C20orf22 homolog	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC499913	similar to Protein C20orf22 homolog			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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